| Name | MGMT |
|---|---|
| Synonyms | 6 O methylguanine DNA methyltransferase; ATase; MGMT; Methylated DNA protein cysteine methyltransferase; Methylated DNA protein cysteine methyltransferase; Methylguanine DNA methyltransferase; O 6 Alkylguanine DNA alkyltransferase; O 6 methylguanine DNA methyltransferase… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17485251 | Hansen RJ, Ludeman SM, Paikoff SJ, Pegg AE, Dolan ME: Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals. DNA Repair. 2007 Aug 1;6(8):1145-54. Epub 2007 May 7. In vitro evidence suggests that MGMT may protect against the urotoxic oxazaphosphorine metabolite, acrolein. |
197(2,3,3,7) | Details |
| 17116724 | Hansen RJ, Nagasubramanian R, Delaney SM, Samson LD, Dolan ME: Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice. Carcinogenesis. 2007 May;28(5):1111-6. Epub 2006 Nov 20. Acrolein and chloroacetaldehyde, metabolites of cyclophosphamide, were not mutagenic in Mgmt+/+ and Mgmt-/- mice. The DNA repair protein O (6)-methylguanine-DNA methyltransferase (MGMT) protects from toxicity and mutations incurred following alkylating agents by removing O (6)-alkylguanine lesions. |
1(0,0,0,1) | Details |
| 4064250 | Krokan H, Grafstrom RC, Sundqvist K, Esterbauer H, Harris CC: Cytotoxicity, thiol depletion and inhibition of O6-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts. Carcinogenesis. 1985 Dec;6(12):1755-9. Lipid peroxidation aldehydes of the 4--alpha, beta-unsaturated type, as well as the tobacco-smoke related alpha, beta-unsaturated acrolein, were highly cytotoxic and decreased the intracellular thiol content in cultured human bronchial fibroblasts after treatment with micromolar concentrations. |
1(0,0,0,1) | Details |