| Name | p50 |
|---|---|
| Synonyms | ARHGEF 7; PAK3; p85; p50; ARHGEF7; BETA PIX; COOL 1; COOL1… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17491020 | Lambert C, Li J, Jonscher K, Yang TC, Reigan P, Quintana M, Harvey J, Freed BM: Acrolein inhibits cytokine gene expression by alkylating and residues in the NF-kappaB1 DNA binding domain. J Biol Chem. 2007 Jul 6;282(27):19666-75. Epub 2007 May 9. Acrolein inhibited NF-kappaB1 (p50) binding to the IL-2 promoter in a chromatin immunoprecipitation assay by > 99%. |
112(1,2,2,2) | Details |
| 9728040 | Zhang J, Patel JM, Block ER: Hypoxia-specific upregulation of calpain activity and gene expression in pulmonary artery endothelial cells. Am J Physiol. 1998 Sep;275(3 Pt 1):L461-8. Specificity of the response to hypoxia was determined by comparing the effects of hypoxic exposure with exposure to oxidants such as (NO2) and (NO), as well as to the sulfhydryl reactive chemical acrolein. In addition, hypoxia increased the degradation of nuclear factor-kappaB (NF-kappaB) inhibitor IkappaB and enhanced the translocation of the p50 subunit of NF-kappaB to the nuclear membrane. |
2(0,0,0,2) | Details |
| 15710356 | Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S, Oh KW, Han DC, Kwon BM, Hong JT: Inhibitory effect of 2'-hydroxycinnamaldehyde on production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem Pharmacol. 2005 Mar 1;69(5):791-9. Epub 2005 Jan 16. Moreover, HCA inhibited LPS-induced p50 and p65 translocation resulting in the inhibition of the DNA binding activity of the NF-kappa B, a central regulator of iNOS. |
1(0,0,0,1) | Details |