| Name | PARP |
|---|---|
| Synonyms | COL11A2; PARP; Collagen alpha 2(XI) chain; Collagen alpha 2(XI) chain precursor; Collagen type XI alpha 2; Collagen type XI alpha 2 isoform 1; DFNA13; DFNB53… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17225077 | Korkmaz A, Topal T, Oter S: Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive and species as well as PARP activation. Cell Biol Toxicol. 2007 Sep;23(5):303-12. Epub 2007 Jan 15. When these molecular factors are taken into account, pathogenesis of CP-induced bladder toxicity can be summarized in three steps: (1) acrolein rapidly enters into the uroepithelial cells; (2) it then activates intracellular reactive species and production (directly or through NF-kappaB and AP-1) leading to production; (3) finally, the increased level damages lipids (lipid peroxidation), proteins (protein oxidation) and DNA (strand breaks) leading to activation of PARP, a DNA repair enzyme. |
34(0,1,1,4) | Details |
| 11723234 | Schwartz PS, Waxman DJ: Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. . Mol Pharmacol. 2001 Dec;60(6):1268-79. Cyclophosphamide (CPA), a widely used oxazaphosphorine anti-cancer prodrug, is inactive until it is metabolized by cytochrome P450 to yield phosphoramide mustard and acrolein, which alkylate DNA and proteins, respectively. CPA and MFA were both shown to effect tumor cell death by stimulating apoptosis, as evidenced by the induction of plasma membrane blebbing, DNA fragmentation, and cleavage of the caspase 3 and caspase 7 substrate poly (ADP- polymerase (PARP) in drug-treated cells. |
2(0,0,0,2) | Details |
| 16343908 | Shin DS, Kim JH, Lee SK, Han DC, Son KH, Kim HM, Cheon HG, Kim KR, Sung ND, Lee SJ, Kang SK, Kwon BM: Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents. Bioorg Med Chem. 2006 Apr 15;14(8):2498-506. Epub 2005 Dec 15. It was confirmed by detection of apoptosis markers such as activated caspase-3 and cleaved PARP, and cell cycle analysis. |
1(0,0,0,1) | Details |
| 19341237 | Pan J, Keffer J, Emami A, Ma X, Lan R, Goldman R, Chung FL: Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by Chem Res Toxicol. 2009 May;22(5):798-806. DHA induced apoptosis in a dose- and time-dependent manner with a concentration range from 0 to 300 microM as indicated by increased caspase-3 activity and PARP cleavage. |
1(0,0,0,1) | Details |