Protein Information

Name Paraoxonase
Synonyms A esterase 1; Aromatic esterase 1; Arylesterase; ESA; Esterase A; K 45; PON; PON 1…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
17632094 Gugliucci A, Lunceford N, Kinugasa E, Ogata H, Schulze J, Kimura S: Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients. Clin Chim Acta. 2007 Sep;384(1-2):105-12. Epub 2007 Jun 23.
168(2,2,3,3) Details
20353174 Kesinger NG, Langsdorf BL, Yokochi AF, Miranda CL, Stevens JF: Formation of a Vitamin C Conjugate of Acrolein and Its Paraoxonase-Mediated Conversion into 5,6,7,8-Tetrahydroxy-4-oxooctanal. Chem Res Toxicol. 2010 Mar 30.
32(0,1,1,2) Details
11223428 Bielicki JK, Knoff LJ, Tribble DL, Forte TM: Relative sensitivities of plasma lecithin:cholesterol acyltransferase, platelet-activating factor acetylhydrolase, and paraoxonase to in vitro gas-phase cigarette smoke exposure. Atherosclerosis. 2001 Mar;155(1):71-8.

Moreover, high doses (1.0-10 mM) of acrolein and 4-hydroxynonenal, reactive aldehydic species associated with cigarette smoke, completely inhibited plasma LCAT activity, whereas PAF-AH was resistant to such exposures.
2(0,0,0,2) Details