Protein Information

Name A2a
Synonyms A2a; A2c; IGKV2D 29; IGKV2D29; immunoglobulin kappa variable 2D 29; A2cs; immunoglobulin kappa variable 2D 29s

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
9626941 Scislo TJ, O'Leary DS: Activation of A2a adenosine receptors in the nucleus tractus solitarius inhibits renal but not lumbar sympathetic nerve activity. J Auton Nerv Syst. 1998 Feb 5;68(3):145-52.

We investigated whether differential changes in regional sympathetic output occur with A2a receptor activation.
In 24 chloralose/urethane anesthetized male Sprague-Dawley rats MAP, HR, renal (RSNA) and lumbar sympathetic nerve activity (LSNA) were recorded simultaneously.
3(0,0,0,3) Details
8832517 Barraco RA, O'Leary DS, Ergene E, Scislo TJ: Activation of purinergic receptor subtypes in the nucleus tractus solitarius elicits specific regional vascular response patterns. J Auton Nerv Syst. 1996 Jul 5;59(3):113-24.

Several lines of evidence indicate that ATP, acting at P2x purinoceptors, and adenosine, acting at A2a adenosine (P1) purinoceptors, play synchronous roles as transmitter substances in NTS-mediated mechanisms of cardiovascular control.
Adult male rats were anesthetized with a mixture of alpha-chloralose and urethane.
2(0,0,0,2) Details
16339828 Scislo TJ, O'Leary DS: Vasopressin V1 receptors contribute to hemodynamic and sympathoinhibitory responses evoked by stimulation of adenosine A2a receptors in NTS. Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1889-98. Epub 2005 Dec 9.

Therefore, we investigated whether blockade of NTS V1 receptors alters the autonomic response patterns evoked by stimulation of NTS A2a receptors (CGS-21680, 20 pmol/50 nl) in alpha-chloralose-urethane anesthetized male Sprague-Dawley rats.
84(1,1,1,4) Details
16100243 McClure JM, O'Leary DS, Scislo TJ: Stimulation of NTS A1 adenosine receptors evokes counteracting effects on hindlimb vasculature. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2536-42. Epub 2005 Aug 12.

Our previous studies concluded that stimulation of the nucleus of the solitary tract (NTS) A2a receptors evokes preferential hindlimb vasodilation mainly via inducing increases in preganglionic sympathetic nerve activity (pre-ASNA) directed to the adrenal medulla.
Therefore, in chloralose-urethane-anesthetized rats, we evaluated the contribution of vasodilator versus vasoconstrictor effects of stimulation of NTS A1 receptors on the hindlimb vasculature.
1(0,0,0,1) Details
19202001 Ichinose TK, O'Leary DS, Scislo TJ: Activation of NTS A2a adenosine receptors differentially resets baroreflex control of renal vs. adrenal sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1058-68. Epub 2009 Feb 6.

To elucidate the role of NTS A (2a) adenosine receptors in baroreflex function, we compared full baroreflex stimulus-response curves for HR, RSNA, and pre-ASNA (intravenous nitroprusside/phenylephrine) before and after bilateral NTS microinjections of selective adenosine A (2a) receptor agonist (CGS-21680; 2.0, 20 pmol/50 nl), selective A (2a) receptor antagonist (ZM-241385; 40 pmol/100 nl), and nonselective A (1) + A (2a) receptor antagonist (8-SPT; 1 nmol/100 nl) in urethane/alpha-chloralose anesthetized rats.
1(0,0,0,1) Details
15539419 Scislo TJ, Tan N, O'Leary DS: Differential role of nitric oxide in regional sympathetic responses to stimulation of NTS A2a adenosine receptors. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H638-49. Epub 2004 Nov 11.

Therefore, in chloralose/urethane-anesthetized rats, we compared hemodynamic and regional sympathetic responses to microinjections of selective A2a receptor agonist (CGS-21680, 20 pmol/50 nl) after pretreatment with NOS inhibitors Nomega-nitro-L-arginine methyl ester (10 nmol/100 nl) and 1-[2-(trifluoromethyl) phenyl] imidazole (100 pmol/100 nl) versus pretreatment with vehicle (100 nl).
32(0,1,1,2) Details
9843813 Scislo TJ, O'Leary DS: Differential control of renal vs. adrenal sympathetic nerve activity by NTS A2a and P2x purinoceptors. Am J Physiol. 1998 Dec;275(6 Pt 2):H2130-9.

RSNA was recorded simultaneously with pre-ASNA or post-ASNA in chloralose-urethan-anesthetized male Sprague-Dawley rats.
3(0,0,0,3) Details