| Name | A2a |
|---|---|
| Synonyms | A2a; A2c; IGKV2D 29; IGKV2D29; immunoglobulin kappa variable 2D 29; A2cs; immunoglobulin kappa variable 2D 29s |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9626941 | Scislo TJ, O'Leary DS: Activation of A2a receptors in the nucleus tractus solitarius inhibits renal but not lumbar sympathetic nerve activity. J Auton Nerv Syst. 1998 Feb 5;68(3):145-52. We investigated whether differential changes in regional sympathetic output occur with A2a receptor activation. In 24 chloralose/urethane anesthetized male Sprague-Dawley rats MAP, HR, renal (RSNA) and lumbar sympathetic nerve activity (LSNA) were recorded simultaneously. |
3(0,0,0,3) | Details |
| 8832517 | Barraco RA, O'Leary DS, Ergene E, Scislo TJ: Activation of purinergic receptor subtypes in the nucleus tractus solitarius elicits specific regional vascular response patterns. J Auton Nerv Syst. 1996 Jul 5;59(3):113-24. Several lines of evidence indicate that ATP, acting at P2x purinoceptors, and acting at A2a (P1) purinoceptors, play synchronous roles as transmitter substances in NTS-mediated mechanisms of cardiovascular control. Adult male rats were anesthetized with a mixture of alpha-chloralose and urethane. |
2(0,0,0,2) | Details |
| 16339828 | Scislo TJ, O'Leary DS: V1 receptors contribute to hemodynamic and sympathoinhibitory responses evoked by stimulation of adenosine A2a receptors in NTS. Am J Physiol Heart Circ Physiol. 2006 May;290(5):H1889-98. Epub 2005 Dec 9. Therefore, we investigated whether blockade of NTS V1 receptors alters the autonomic response patterns evoked by stimulation of NTS A2a receptors (CGS-21680, 20 pmol/50 nl) in alpha-chloralose-urethane anesthetized male Sprague-Dawley rats. |
84(1,1,1,4) | Details |
| 16100243 | McClure JM, O'Leary DS, Scislo TJ: Stimulation of NTS A1 receptors evokes counteracting effects on hindlimb vasculature. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2536-42. Epub 2005 Aug 12. Our previous studies concluded that stimulation of the nucleus of the solitary tract (NTS) A2a receptors evokes preferential hindlimb vasodilation mainly via inducing increases in preganglionic sympathetic nerve activity (pre-ASNA) directed to the adrenal medulla. Therefore, in chloralose-urethane-anesthetized rats, we evaluated the contribution of vasodilator versus vasoconstrictor effects of stimulation of NTS A1 receptors on the hindlimb vasculature. |
1(0,0,0,1) | Details |
| 19202001 | Ichinose TK, O'Leary DS, Scislo TJ: Activation of NTS A2a receptors differentially resets baroreflex control of renal vs. sympathetic nerve activity. Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1058-68. Epub 2009 Feb 6. To elucidate the role of NTS A (2a) receptors in baroreflex function, we compared full baroreflex stimulus-response curves for HR, RSNA, and pre-ASNA (intravenous nitroprusside/ before and after bilateral NTS microinjections of selective A (2a) receptor agonist (CGS-21680; 2.0, 20 pmol/50 nl), selective A (2a) receptor antagonist (ZM-241385; 40 pmol/100 nl), and nonselective A (1) + A (2a) receptor antagonist (8-SPT; 1 nmol/100 nl) in urethane/alpha-chloralose anesthetized rats. |
1(0,0,0,1) | Details |
| 15539419 | Scislo TJ, Tan N, O'Leary DS: Differential role of in regional sympathetic responses to stimulation of NTS A2a receptors. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H638-49. Epub 2004 Nov 11. Therefore, in chloralose/urethane-anesthetized rats, we compared hemodynamic and regional sympathetic responses to microinjections of selective A2a receptor agonist (CGS-21680, 20 pmol/50 nl) after pretreatment with NOS inhibitors Nomega-nitro- methyl ester (10 nmol/100 nl) and 1-[2-(trifluoromethyl) phenyl] (100 pmol/100 nl) versus pretreatment with vehicle (100 nl). |
32(0,1,1,2) | Details |
| 9843813 | Scislo TJ, O'Leary DS: Differential control of renal vs. sympathetic nerve activity by NTS A2a and P2x purinoceptors. Am J Physiol. 1998 Dec;275(6 Pt 2):H2130-9. RSNA was recorded simultaneously with pre-ASNA or post-ASNA in chloralose-urethan-anesthetized male Sprague-Dawley rats. |
3(0,0,0,3) | Details |