| Name | glutathione S transferase P |
|---|---|
| Synonyms | DFN 7; PI; DFN7; FAEES 3; FAEES3; GST class pi; GST3; GSTP 1… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9463521 | van Iersel ML, Ploemen JP, Lo Bello M, Federici G, van Bladeren PJ: Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1. Chem Biol Interact. 1997 Dec 12;108(1-2):67-78. When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and (HNE) and the ketones (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1. |
85(1,1,1,5) | Details |
| 10799737 | Pal A, Hu X, Zimniak P, Singh SV: Catalytic efficiencies of allelic variants of human glutathione S-transferase Pi in the conjugation of alpha, beta-unsaturated aldehydes. Cancer Lett. 2000 Jun 1;154(1):39-43. The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 or and/or 113 or in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined. |
32(0,1,1,2) | Details |
| 12718659 | Satoh K: Increase Intake of for Prevention of Cancer: an Enzymological Lesson?. Asian Pac J Cancer Prev. 2001;2(1):75-80. However, the species of glutathione S-transferases (GSTP1-1) linked to neoplasia of rat and human were recently shown to be selective for hydrophilic carcinogens such as acrolein and hydroxyalkenals (Satoh, 1998; Satoh et al., 1999) in accord with the finding of a water-network in the active site of the human GSTP1-1 by X-ray analysis (Hu et al.; Ji et al., 1997). |
31(0,1,1,1) | Details |
| 19696094 | Conklin DJ, Haberzettl P, Lesgards JF, Prough RA, Srivastava S, Bhatnagar A: Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity. J Pharmacol Exp Ther. 2009 Nov;331(2):456-69. Epub 2009 Aug 20. Herein, we tested the hypothesis that glutathione S-transferase P (GSTP), the GST isoform that displays high catalytic efficiency with acrolein, protects against CY-induced urotoxicity by detoxifying acrolein. |
7(0,0,1,2) | Details |
| 9771939 | Satoh K: Weak electrophile selective characteristics of the rat preneoplastic marker enzyme glutathione S-transferase P-form, GST-P (7-7): a theory of linear free energy relationships for evaluation of the active site hydrophobicity of isoenzymes. Carcinogenesis. 1998 Sep;19(9):1665-71. As these thermodynamic parameters, deltadeltaG degrees and deltadeltaH degrees, may be considered as indirect and direct measures of GST hydrophobicity respectively, the H-site hydrophobicity of GST-P is thus very low as compared with those of other forms, clearly indicating that the pi class GST-P selectively targets for weak electrophiles, i.e. water-soluble carcinogens such as acrolein and hydroxyalkenals. |
2(0,0,0,2) | Details |
| 19270193 | Conklin DJ, Haberzettl P, Prough RA, Bhatnagar A: Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1586-97. Epub 2009 Mar 6. The P isoform of GST (GSTP), which catalyzes the conjugation of electrophilic molecules in cigarette smoke such as acrolein, was expressed in high abundance in the mouse lung and aorta. |
1(0,0,0,1) | Details |
| 9240470 | Fukuda A, Nakamura Y, Ohigashi H, Osawa T, Uchida K: Cellular response to the redox active lipid peroxidation products: induction of glutathione S-transferase P by Biochem Biophys Res Commun. 1997 Jul 18;236(2):505-9. We found that the GST activity in RL34 cells was induced by alpha,beta-unsaturated aldehydes, such as acrolein (1.3-fold), crotonaldehyde (1.3-fold), 4--2-hexenal (HHE) (1.4-fold), and (HNE) (1.7-fold). |
1(0,0,0,1) | Details |
| 8950226 | Iersel ML, Ploemen JP, Struik I, van Amersfoort C, Keyzer AE, Schefferlie JG, van Bladeren PJ: Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Chem Biol Interact. 1996 Oct 21;102(2):117-32. Reversible inhibition of GST was the major mechanism of inhibition of DNPSG-excretion in melanoma cells, except in the cases of and ethacrynic acid, which compounds also inactivated GSTP1-1 by covalent modification. Effects of acrolein, citral, crotonaldehyde, ethacrynic acid, and trans-2-hexenal.. |
1(0,0,0,1) | Details |
| 11600134 | Satoh K, Hayakari M, Ookawa K, Satou M, Aizawa S, Tanaka M, Hatayama I, Tsuchida S, Uchida K: Lipid peroxidation end products-responded induction of a preneoplastic marker enzyme glutathione S-transferase P-form (GST-P) in rat liver on admistration via the portal vein. Mutat Res. 2001 Nov 1;483(1-2):65-72. Unsaturated aldehydes, crotonaldehyde and acrolein, given by the same route induced putatively preneoplastic single cells positive for GST-P. |
2(0,0,0,2) | Details |
| 7728969 | Satoh K: The high non-enzymatic conjugation rates of some glutathione S-transferase (GST) substrates at high concentrations. Carcinogenesis. 1995 Apr;16(4):869-74. GSTP1-1 showed a broad substrate specificity with both low and high GSH (10 mM) concentrations at pH 7.0, and the inhibitor insensitivity was then prominent. The half-time for acrolein estimated by extrapolation was approximately 0.5 s. |
1(0,0,0,1) | Details |
| 9882456 | Satoh K, Sato R, Takahata T, Suzuki S, Hayakari M, Tsuchida S, Hatayama I: Quantitative differences in the active-site hydrophobicity of five human glutathione S-transferase isoenzymes: water-soluble carcinogen-selective properties of the neoplastic GSTP1-1 species. Arch Biochem Biophys. 1999 Jan 15;361(2):271-6. In contrast to the Alpha and Mu classes being selective for strongly electrophilic compounds, the neoplastic P1-1 species was indicated to be selective for weakly electrophilic and water-soluble carcinogens such as acrolein and hydroxyalkenals. |
1(0,0,0,1) | Details |