| Name | hemoglobin (protein family or complex) |
|---|---|
| Synonyms | Hemoglobin; Hemoglobins |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3236330 | Hoberman HD, San George RC: Reaction of tobacco smoke aldehydes with human hemoglobin. . J Biochem Toxicol. 1988 Summer;3:105-19. and acrolein produced a heterogeneous mixture of derivatives including cross-linked hemoglobin dimers. |
91(1,1,2,6) | Details |
| 2222504 | Ferrali M, Ciccoli L, Signorini C, Comporti M: release and erythrocyte damage in allyl alcohol intoxication in mice. Biochem Pharmacol. 1990 Oct 1;40(7):1485-90. Studies carried out with reconstituted systems of erythrocyte lysates, containing ghosts and different fractions of erythrocyte cytosol and incubated in the presence of acrolein (the major metabolite of allyl strongly suggest that iron is released from hemoglobin. |
81(1,1,1,1) | Details |
| 19722825 | Aldini G, Vistoli G, Regazzoni L, Benfatto MC, Bettinelli I, Carini M: Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms. Antioxid Redox Signal. 2010 Mar;12(3):381-92. The aim of this study was to evaluate the ability of the well-known radical scavenging compound edaravone (EDA) to entrap and detoxify reactive carbonyl species (RCS) derived from lipid peroxidation [4-hydroxy-trans-2-nonenal (HNE), acrolein and glyoxal], as well as its ability to prevent RCS-induced protein carbonylation, by using hemoglobin (Hb) modified by HNE as an in vitro model. |
31(0,1,1,1) | Details |
| 17034917 | Scherer G, Engl J, Urban M, Gilch G, Janket D, Riedel K: Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany. Regul Toxicol Pharmacol. 2007 Mar;47(2):171-83. Epub 2006 Oct 10. The following biomarkers were determined: In 24-h urine: equivalents (molar sum of and their respective glucuronides), 4-(methylnitrosamino)-1-(3-pyridyl)- (NNAL, metabolite of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- NNK), 3-hydroxypropylmercapturic acid (metabolite of acrolein), trans,trans-muconic acid, S-phenylmercapturic acid (metabolites of 1-hydroxypyrene (metabolite of pyrene); in saliva: and in exhaled air: in blood: Methyl-, hydroxyethyl-, cyanoethyl- (biomarker of acrylonitrile) and carbamoylethylvaline (biomarker of acrylamide) hemoglobin adducts. |
31(0,1,1,1) | Details |
| 11162777 | Ambalavanan N, Carlo WF, Bulger A, Shi J, Philips JB 3rd: Effect of cigarette smoke extract on neonatal porcine vascular smooth muscle cells. Toxicol Appl Pharmacol. 2001 Jan 15;170(2):130-6. The effects of known constituents of CSE benzopyrene, acrolein, aged CSE, CSE with added hemoglobin, devolatilized CSE, CSE with added (DTT), and (GSH) on cell proliferation and viability were assessed. |
7(0,0,1,2) | Details |
| 11487471 | Adams S, Green P, Claxton R, Simcox S, Williams MV, Walsh K, Leeuwenburgh C: Reactive carbonyl formation by oxidative and non-oxidative pathways. Front Biosci. 2001 Aug 1;6:A17-24. We investigated model proteins and a variety of oxidative and non-oxidative reactions, as well as what effects hemoglobin, myoglobin, and cytochrome c might have on levels of protein carbonyls. Other non-oxidative modification systems, in which proteins are incubated with various aldehydes, such as malondialdehyde, acrolein, and glyoxal also generated significant amounts of carbonyls. |
3(0,0,0,3) | Details |
| 2805232 | Kautiainen A, Tornqvist M, Svensson K, Osterman-Golkar S: Adducts of malonaldehyde and a few other aldehydes to hemoglobin. . Carcinogenesis. 1989 Nov;10(11):2123-30. |
2(0,0,0,2) | Details |
| 17140783 | Subash Babu P, Prabuseenivasan S, Ignacimuthu S: --a potential antidiabetic agent. Phytomedicine. 2007 Jan;14(1):15-22. Epub 2006 Nov 30. In addition, oral administration of (20 mg/kg bw) significantly decreased glycosylated hemoglobin (HbA (1C)), serum total triglyceride levels and at the same time markedly increased plasma insulin, hepatic and high-density lipoprotein- levels. |
1(0,0,0,1) | Details |
| 19481578 | Mendes P, Liang Q, Frost-Pineda K, Munjal S, Walk RA, Roethig HJ: The relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the US. Regul Toxicol Pharmacol. 2009 Oct;55(1):17-27. Epub 2009 May 28. Methods: This study used a stratified, cross-sectional, multi-center design to estimate biomarkers of exposure (BOE) from 4-(methylnitrosamino)-1-(3-pyridyl)-1- (NNK), pyrene, CO, acrolein, and 1,3-butadiene and their relationship to tar yield categories of cigarette in adult smokers in the U.S. 3625 adults smokers were enrolled into four tar categories < or =2.9 mg (T1), 3.0-6.9 mg (T2), 7.0-12.9 mg (T3), and > or =13.0mg (T4). Biomarkers were measured in blood (carboxyhemoglobin, 4-aminobiphenyl-hemoglobin (4-ABP-Hb)-adducts, serum and 24h urine and five metabolites, calculated as equivalents (NE), NNAL, 1-OH-pyrene, 3-HPMA, MHBMA and DHBMA). |
1(0,0,0,1) | Details |
| 16490072 | Hata I, Kaji M, Hirano S, Shigematsu Y, Tsukahara H, Mayumi M: Urinary oxidative stress markers in young patients with type 1 diabetes. Pediatr Int. 2006 Feb;48(1):58-61. The concentrations of acrolein- adducts, were determined using competitive enzyme-linked immunosorbent assay, and metabolites were measured using the colorimetric, non-enzymatic assay. Hemoglobin A (1c) values were significantly correlated with values. |
1(0,0,0,1) | Details |
| 8319634 | Eder E, Hoffman C, Sporer S, Scheckenbach S: Biomonitoring studies and susceptibility markers for acrolein congeners and allylic and benzyl compounds. Environ Health Perspect. 1993 Mar;99:245-7. Of the biomonitoring methods investigated for allylic and benzyl compounds, the detection of and adducts isolated from hemoglobin seems to be the most sensitive. |
1(0,0,0,1) | Details |