Protein Information

Name caspase activated DNase
Synonyms CAD; CPAN; Caspase activated DNase; Caspase activated deoxyribonuclease; Caspase activated nuclease; DFF 2; DFF 40; DFF2…

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
15843039 Tanel A, Averill-Bates DA: The aldehyde acrolein induces apoptosis via activation of the mitochondrial pathway. Biochim Biophys Acta. 2005 Apr 15;1743(3):255-67. Epub 2005 Jan 5.

The induction of apoptosis by acrolein was confirmed morphologically by the condensation of nuclear chromatin and by the cleavage of the inhibitor of caspase activated DNase (ICAD), which leads to the liberation of CAD that causes DNA fragmentation.
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