Protein Information

Name N acetyltransferase
Synonyms AAC 2; NAT2; AAC2; ARY 2; ARY2; Arylamide acetylase 2; Arylamine N acetyltransferase 2; N acetyltransferase…

Compound Information

Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
1697652 Attia AM, Mostafa MH, Soliman SA, el-Sebae AH, Nonaka KO, Withyachumnarnkul B, Reiter RJ: The organochlorine insecticide 1,2,3,4,5,6-hexachlorocyclohexane (lindane) but not 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) augments the nocturnal increase in pineal N-acetyltransferase activity and pineal and serum melatonin levels. Neurochem Res. 1990 Jul;15(7):673-80.

The effect of organochlorine insecticides lindane (1,2,3,4,5,6-hexachlorocyclohexane) and DDT (1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane) were studied in terms of their effects on the rat pineal N-acetyltransferase (NAT) activity, hydroxyindole-O-methyltransferase (HIOMT) activity and pineal and serum melatonin levels during the day (2000h) and at night (2300 and 0100h).
6(0,0,1,1) Details
1718548 Attia AM, Richardson BA, Rodriguez C, Mostafa MH, Soliman SA, el-Sebae AH, Reiter RJ: Lindane may enhance nocturnal pineal N-acetyltransferase activity via beta-adrenergic receptors. Brain Res. 1991 Jul 19;554(1-2):253-6.

Lindane, a chlorinated hydrocarbon pesticide, was previously shown to enhance the nighttime rise in pineal N-acetyltransferase (NAT) activity and melatonin as well as serum melatonin levels.
87(1,1,2,2) Details
7545037 Attia AM, Vaughan MK, Rodriguez C, Reiter RJ: Lindane and DDT-induced changes in rat harderian N-acetyltransferase activity, melatonin levels, and porphyrin concentration. Bull Environ Contam Toxicol. 1995 Jul;55(1):14-21.
6(0,0,1,1) Details
1699720 Moreteau B, Chaminade N: The effects of lindane poisoning on N-acetyldopamine and N-acetyl 5-hydroxytryptamine concentrations in the brain of Locusta migratoria L. Ecotoxicol Environ Saf. 1990 Aug;20(1):115-20.

These results can be correlated with a decrease in N-acetyltransferase activity.
1(0,0,0,1) Details