| Name | Substance P |
|---|---|
| Synonyms | Hs.2563; PPT; NK2; NKA; NKNA; Neurokinin 1; Neurokinin 2; Neurokinin A… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7540111 | Wilson LB, Wall PT, Matsukawa K: Attenuation of the reflex responses to muscle contraction by the coadministration of antagonists to substance P and somatostatin into the dorsal horn. Cardiovasc Res. 1995 Mar;29(3):379-84. METHODS: Using alpha chloralose anaesthetised cats (n = 8), static contraction and stretch of the triceps surae muscle were performed before and after microinjecting (1 microliter) 250 ng of the substance P antagonist, D-Pro2-D-Phe7-D-Trp9-substance P, and the somatostatin antagonist, cyclo (7-amino-heptanoyl-phenylalanyl-D-tryptophyl-lysyl-threonyl-[ benzyl]). |
34(0,1,1,4) | Details |
| 7582496 | Cumberbatch MJ, Chizh BA, Headley PM: Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord. Br J Pharmacol. 1995 Jul;115(6):1005-12. The agonists were applied by microiontophoresis in in vivo experiments in alpha-chloralose-anaesthetized, spinalized rats. 2. The NK1-selective agonist, GR 73632, enhanced responses to all three EAAs similarly, whilst the NK2-selective agonist, GR64349, reduced responses to AMPA and kainate without affecting those to and the NK3 selective agonist, senktide, enhanced responses to AMPA and kainate. 3. |
3(0,0,0,3) | Details |
| 9502263 | Radhakrishnan V, Iyengar S, Henry JL: The nonpeptide NK-1 receptor antagonists LY303870 and LY306740 block the responses of spinal dorsal horn neurons to substance P and to peripheral noxious stimuli. Neuroscience. 1998 Apr;83(4):1251-60. Extracellular recordings were obtained using multi-barrel electrodes from L4-L7 segments of the spinal cord in cats anaesthetized with alpha-chloralose and spinalized at the L1 level. |
3(0,0,0,3) | Details |
| 7537469 | Nobrega AC, Meintjes AF, Ally A, Wilson LB: Modulation of reflex pressor response to contraction and effect on substance P release by spinal 5-HT1A receptors. Am J Physiol. 1995 Apr;268(4 Pt 2):H1577-85. Static contractions of the triceps surae muscle of chloralose-anesthetized cats were induced by stimulating the cut L7 and S1 ventral roots. |
2(0,0,0,2) | Details |
| 11223003 | Potts JT, Fuchs IE: Naturalistic activation of barosensitive afferents release substance P in the nucleus tractus solitarius of the cat. Brain Res. 2001 Mar 2;893(1-2):155-64. Experiments were performed on chloralose anesthetized, artificially ventilated and paralyzed cats. |
2(0,0,0,2) | Details |
| 7537771 | Krowicki ZK, Hornby PJ: Substance P and independently affect intragastric pressure when microinjected into the nucleus raphe obscurus of the rat. J Auton Nerv Syst. 1995 Feb 9;51(2):175-9. This was accomplished by microinjection of SP (135 pmol) and (0.6 and 6 nmol) into the NRO in a rapid, sequential order in alpha-chloralose-anesthetized rats, while monitoring intragastric pressure and pyloric and greater curvature motilities. |
3(0,0,0,3) | Details |
| 7682858 | Radhakrishnan V, Henry JL: L-NAME blocks responses to substance P and noxious cutaneous stimuli in cat dorsal horn. Neuroreport. 1993 Mar;4(3):323-6. The synthase inhibitor, NG-nitro- methyl ester (L-NAME), administered i.v. (50 mg kg-1) or by iontophoresis, was tested on the responses of spinal dorsal horn neurones in cats anaesthetized with alpha-chloralose and spinally transected at the L1 level. |
3(0,0,0,3) | Details |
| 10516253 | Swiatkowski K, Dellamano LM, Vissing J, Rybicki KJ, Kozlowski GP, Iwamoto GA: Differential effects from parapyramidal region and rostral ventrolateral medulla mediated by substance P. Am J Physiol. 1999 Oct;277(4 Pt 2):R1120-9. We investigated the involvement of SP at the IML in mediating rVLM- and PPr-evoked pressor responses in the chloralose-anesthetized cat. |
2(0,0,0,2) | Details |
| 7542180 | Meintjes AF, Nobrega AC, Fuchs IE, Ally A, Wilson LB: Attenuation of the exercise pressor reflex. Circ Res. 1995 Aug;77(2):326-34. Effect of opioid agonist on substance P release in L-7 dorsal horn of cats.. Using alpha-chloralose-anesthetized cats, we studied blood pressure and heart rate responses to static contraction and passive stretch of the triceps surae muscle before and after microdialyzing the mu-opioid agonist [D-Ala2]- enkephalinamide (DAME, 200 mumol/L) into the L-7 dorsal horn of the spinal cord. |
3(0,0,0,3) | Details |
| 7694501 | Krowicki ZK, Hornby PJ: Opposing gastric motor responses to TRH and substance P on their microinjection into nucleus raphe obscurus of rats. Am J Physiol. 1993 Nov;265(5 Pt 1):G819-30. Therefore, we investigated the effects of microinjection of these peptides (in a volume of 60 nl) into the caudal NRO of alpha-chloralose-anesthetized rats while recording intragastric pressure, pyloric and greater curvature motility, and blood pressure. |
2(0,0,0,2) | Details |
| 9882754 | Potts JT, Fuchs IE, Li J, Leshnower B, Mitchell JH: Skeletal muscle afferent fibres release substance P in the nucleus tractus solitarii of anaesthetized cats. J Physiol. 1999 Feb 1;514 ( Pt 3):829-41. The tachykinin substance P was recovered from the commissural subdivision of the nucleus tractus solitarii (cNTS) using in vivo microdialysis during activation of cardiorespiratory and skeletal muscle receptors in thirteen chloralose-anaesthetized cats. 2. |
37(0,1,1,7) | Details |
| 9588691 | Walczewska A, Szkudlarek U, Jakubowska-Naziemblo B, Dziedzic B, Traczyk WZ: Increase of gonadotropin-releasing hormone concentration in pituitary portal blood after substance P administration in male rats. Neuroendocrinology. 1998 Apr;67(4):219-27. The pituitary glands were exposed by the transpharyngeal approach under urethane-chloralose anesthesia. |
2(0,0,0,2) | Details |
| 1370923 | Wilson LB, Wall PT, Matsukawa K, Mitchell JH: Effect of spinal microinjections of an antagonist to substance P or somatostatin on the exercise pressor reflex. Circ Res. 1992 Feb;70(2):213-22. Anesthesia was induced by administering an anesthetic gas mixture and was subsequently maintained with alpha-chloralose. |
2(0,0,0,2) | Details |
| 8536296 | Edvinsson L, Jansen Olesen I, Kingman TA, McCulloch J, Uddman R: Modification of vasoconstrictor responses in cerebral blood vessels by lesioning of the trigeminal nerve: possible involvement of CGRP. Cephalalgia. 1995 Oct;15(5):373-83. The functional role of the trigeminal system has been addressed in experiments on the cortical surface of alpha-chloralose anaesthetized cats. Substance P (SP) was less potent but showed dilatation of both arterioles (21 +/- 4%) and veins (16 +/- 4%). |
2(0,0,0,2) | Details |
| 9383221 | Radhakrishnan V, Henry JL: Electrophysiological evidence that neurokinin A acts via NK-1 receptors in the cat dorsal horn. Eur J Neurosci. 1997 Sep;9(9):1977-85. The aim of the present study was to investigate the effects of the non-peptide NK-2 receptor antagonist, SR 48968 on the responses of dorsal horn neurons to iontophoretic application of the endogenous NK-2 receptor ligand, neurokinin A, and on synaptically elicited responses in chloralose-anaesthetized cats. |
35(0,1,1,5) | Details |
| 7538641 | Radhakrishnan V, Henry JL: Antagonism of nociceptive responses of cat spinal dorsal horn neurons in vivo by the NK-1 receptor antagonists CP-96,345 and CP-99,994, but not by CP-96,344. Neuroscience. 1995 Feb;64(4):943-58. Extracellular and intracellular studies were undertaken to test the effects of the non-peptide, substance P (NK-1) receptor antagonists CP-96,345 and CP-99,994, and of CP-96,344, the inactive enantiomer of CP-96,345, on the responses of spinal dorsal horn neurons to peripheral noxious and non-noxious cutaneous stimuli in spinalized cats anesthetized with alpha-chloralose. |
35(0,1,1,5) | Details |
| 8525117 | Pizarro J, Ryan ML, Hedrick MS, Xue DH, Keith IM, Bisgard GE: Intracarotid substance P infusion inhibits ventilation in the goat. Respir Physiol. 1995 Jul;101(1):11-22. Awake (n = 14) and chloralose anesthetized goats (n = 6) were used to investigate the effects of intracarotid (IC) SP infusions (1-6 micrograms.kg-1.min-1) and bolus injections (6 micrograms kg-1) to the CB intact and denervated (CBX) sides (control) on mean ventilation (VE) and mean blood pressure (MBP). |
2(0,0,0,2) | Details |
| 7515576 | Krowicki ZK, Hornby PJ: TRH and substance P independently affect gastric motility in nucleus raphe obscurus of the rat. Am J Physiol. 1994 May;266(5 Pt 1):G870-7. This was accomplished by microinjection of TRH (6-45 pmol) and SP (10 and 135 pmol) into the NRO alone and then either as a mixture or in rapid sequential order in alpha-chloralose-anesthetized rats, while intragastric pressure and pyloric and greater curvature motility were monitored. |
2(0,0,0,2) | Details |
| 17928644 | Zubrzycka M, Janecka A: Effect of galanin on substance P- and vasoactive intestinal polypeptide-induced nociceptive trigemino-hypoglossal reflex in rats. J Physiol Pharmacol. 2007 Sep;58(3):479-86. The experiments were carried out on rats under chloralose anesthesia. |
2(0,0,0,2) | Details |
| 18554294 | Bongianni F, Mutolo D, Cinelli E, Pantaleo T: Neurokinin receptor modulation of respiratory activity in the rabbit. Eur J Neurosci. 2008 Jun;27(12):3233-43. Epub 2008 Jun 1. The respiratory role of neurokinin (NK) receptors was investigated in alpha-chloralose-urethane-anaesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nL) of NK receptor agonists and antagonists. We used as agonists (0.1, 0.5 and 5 mM) substance P (SP), the NK1 receptor agonists [Sar (9), Met (O2)(11)]-SP and GR 73632, the NK2 receptor agonist NKA, the NK3 receptor agonist senktide, and as antagonists (5 mM) the NK1 receptor antagonist CP-99,994 and the NK2 receptor antagonist MEN 10376. |
1(0,0,0,1) | Details |
| 7582497 | Chizh BA, Cumberbatch MJ, Birch PJ, Headley PM: Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK1 and NK2 receptors in the rat spinal cord. Br J Pharmacol. 1995 Jul;115(6):1013-9. The effects of selective tachykinin (neurokinin, NK) NK1 and NK2 receptor antagonists have been examined on spinal neurones in alpha-chloralose anaesthetized, spinalized rats. |
34(0,1,1,4) | Details |
| 8738311 | Krowicki ZK, Hornby PJ: The inhibitory effect of substance P on gastric motor function in the nucleus raphe obscurus is mediated via in the dorsal vagal complex. J Auton Nerv Syst. 1996 May 6;58(3):177-80. Substance P (135 pmol) was microinjected into the nROb 3-6 min after bilateral microinjections of L-NAME (45 nmol per site) into the DVC of chloralose-anesthetized rats were started. |
8(0,0,1,3) | Details |
| 1722199 | Haxhiu MA, Cherniack NS, Strohl KP: Reflex responses of laryngeal and pharyngeal submucosal glands in dogs. J Appl Physiol. 1991 Nov;71(5):1669-73. In dogs tracheal secretion is enhanced reflexly and by locally acting mediators such as substance P (SP). In six alpha-chloralose-anesthetized, paralyzed, and artificially ventilated dogs, submucosal gland secretion was monitored by analyzing the areas covered by hillocks of liquid and calculating the volume of secreted liquid (microliter) in the L and Ph. |
1(0,0,0,1) | Details |
| 9724281 | Wilson LB, Hand GA: Segmental effect of spinal NK-1 receptor blockade on the pressor reflex. Am J Physiol. 1998 Sep;275(3 Pt 2):H789-96. The physiological effects of substance P (SP) are mediated via activation of neurokinin-1 (NK-1) receptors. Cats were anesthetized with alpha-chloralose and urethan, and a laminectomy was performed. |
1(0,0,0,1) | Details |
| 9453348 | Diz DI, Westwood B, Bosch SM, Ganten D, Ferrario C: NK1 receptor antagonist blocks angiotensin II responses in renin transgenic rat medulla oblongata. Hypertension. 1998 Jan;31(1 Pt 2):473-9. Angiotensin (Ang) II increases substance P (SP) efflux from perfused slices of medulla oblongata, and a peptide antagonist of SP, [Leu11,psiCH2NH10-11] SP, blocks the acute hypotension and bradycardia caused by Ang II injected into the nucleus tractus solitarii (nTS) of Harlan Sprague-Dawley (SD) rats. Injections of Ang II (250 fmol in 30 nL) into the nTS of chloralose-urethane anesthetized TG rats produced a significant increase in pressure of 7+/-2 mm Hg before a 13+/-3 mm Hg fall in pressure. |
1(0,0,0,1) | Details |
| 1377632 | Perez H, Ruiz S, Inostroza H, Perretta M: Substance P depresses bioelectrical responses evoked in the nucleus tractus solitarii: interaction with -ergic neurons. Eur J Pharmacol. 1992 Mar 31;213(3):435-7. The effects of intracerebroventricular (i.c.v.) administration of substance P (SP) and on responses evoked in the nucleus tractus solitarii (NTS) by electrical stimulation of the ipsilateral sinusal nerve were studied in alpha-chloralose-anesthetized rats. |
7(0,0,1,2) | Details |
| 7520553 | Williams CA, Brien PL, Nichols PL, Gopalan R: Detection of immunoreactive substance P-like substances from cat brainstem sites during fatiguing isometric contractions. Neuropeptides. 1994 May;26(5):319-27. Isometric contractions were generated on the left hindlimb muscles from adult cats (n = 11) anesthetized with alpha-chloralose (75 mg/kg) to determine whether immunoreactive substance P (irSP) was released from either the right periaqueductal grey (PAG) or ventrolateral medulla (VLM), sites shown to be involved with the integration of the muscle pressor response. |
7(0,0,1,2) | Details |
| 12560109 | Williams CA, Ecay T, Reifsteck A, Fry B, Ricketts B: Direct injection of substance P-antisense oligonucleotide into the feline NTS modifies the cardiovascular responses to ergoreceptor but not baroreceptor afferent input. Brain Res. 2003 Feb 14;963(1-2):26-42. Substance P (SP) is released from the feline nucleus tractus solitarius (NTS) in response to activation of skeletal muscle afferent input. An anti-sense oligonucleotide to feline SP (SP-asODN) was injected directly into the rostral NTS of chloralose-anesthetized cats to determine whether blood pressure or heart rate responses to ergoreceptor activation (muscle contraction) or baroreceptor unloading (carotid artery occlusion) were sensitive to SP knockdown. |
1(0,0,0,1) | Details |
| 1710070 | Zhu WJ, Zhang RB: [Effect of hypothalamic stimulation on RMBF and SP content in IML of spinal cord in rabbits]. Sheng Li Xue Bao. 1991 Feb;43(1):38-45. Experiments were performed on 48 urethane-chloralose anaesthetized, gallamine triethiodide immobilized and vagotomized rabbits under artificial ventilation. In intact rabbits, it was demonstrated that DMH stimulation caused an decrease of substance P (SP) immunoreactive material in bilateral intermediolateral cell columns (IML) of T2-5 spinal cord concomitantly with an elevation in MABP and EECG ST changes. |
1(0,0,0,1) | Details |
| 7693361 | Wilson LB, Fuchs IE, Mitchell JH: Effects of graded muscle contractions on spinal cord substance P release, arterial blood pressure, and heart rate. Circ Res. 1993 Dec;73(6):1024-31. The release of substance P (SP)-like immunoreactivity (SP-LI) in the dorsal horn of the spinal cord and the cardiovascular changes to both high-tension (HT) and low-tension (LT) contractions were determined using alpha-chloralose-anesthetized cats. |
7(0,0,1,2) | Details |
| 9692766 | Goadsby PJ, Hoskin KL, Knight YE: Substance P blockade with the potent and centrally acting antagonist GR205171 does not effect central trigeminal activity with superior sagittal sinus stimulation. Neuroscience. 1998 Sep;86(1):337-43. One such suggested approach has been substance P (neurokinin-1) antagonists, since substance P is involved in mediating neurogenic plasma protein extravasation and has long been held to have a role in pain transmission. The superior sagittal sinus was isolated in the alpha-chloralose (60 mg/kg, i.p., and 20 mg/kg, i.v., supplemented every 2 h)-anaesthetized cat. |
3(0,0,0,3) | Details |
| 12106662 | Williams CA, Reifsteck A, Hampton TA, Fry B: Substance P release in the feline nucleus tractus solitarius during ergoreceptor but not baroreceptor afferent signaling. Brain Res. 2002 Jul 19;944(1-2):19-31. Substance P (SP) is associated with metabo- and mechanoreceptor afferent fibers ('ergoreceptors') in skeletal muscle as well as the afferent fibers from carotid sinus baroreceptors. Both the muscle pressor response and the baroreflex were studied in adult cats anaesthetized with alpha-chloralose. |
1(0,0,0,1) | Details |
| 8385759 | Goadsby PJ: Inhibition of calcitonin gene-related peptide by h-CGRP (8-37) antagonizes the cerebral dilator response from nasociliary nerve stimulation in the cat. Neurosci Lett. 1993 Mar 5;151(1):13-6. The head is innervated by neurons with cell bodies in the trigeminal ganglion that contain both calcitonin gene-related peptide (CGRP) and substance P. In this study, the CGRP antagonist h-CGRP (8-37) was examined for its ability to interfere with trigeminal-evoked cerebral vasodilator responses in the alpha-chloralose anaesthetised cat. |
1(0,0,0,1) | Details |
| 7683719 | Wilson LB, Fuchs IE, Matsukawa K, Mitchell JH, Wall PT: Substance P release in the spinal cord during the exercise pressor reflex in anaesthetized cats. J Physiol. 1993 Jan;460:79-90. A laminectomy was performed to expose the spinal cord of alpha-chloralose anaesthetized cats. |
3(0,0,0,3) | Details |
| 1718570 | Bereiter DA, Benetti AP: Microinjections of calcitonin gene-related peptide within the trigeminal subnucleus caudalis of the cat affects and autonomic function. Brain Res. 1991 Aug 30;558(1):53-62. To assess the role of calcitonin gene-related peptide (CGRP) within the trigeminal subnucleus caudalis (Vc) on and autonomic function, microinjections were directed at different laminae of Vc in chloralose-anesthetized cats. To examine if CGRP interacts with substance P within Vc to modify and autonomic function, subthreshold doses of each peptide were injected alone and simultaneously. |
3(0,0,0,3) | Details |