| Name | alpha1 adrenoceptors (protein family or complex) |
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| Synonyms | Alpha adrenoceptor; Alpha adrenoceptor; Alpha adrenergic receptor; Alpha adrenergic receptors; Alpha adrenoceptors; Alpha adrenoceptors; alpha1 Adrenoceptors; alpha1 Adrenoceptor… |
| Name | chloralose |
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| CAS |
| PubMed | Abstract | RScore(About this table) | |
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| 8750702 | Geller JC, Cua M, Prieto L, Guo SD, Danilo P Jr, Rosen MR: Chloroethylclonidine increases the incidence of lethal arrhythmias during coronary occlusion in anesthetized dogs. Eur J Pharmacol. 1995 Dec 29;294(2-3):423-8. We studied the role of alpha1-adrenoceptors in the modulation of ventricular tachycardia and fibrillation in chloralose-anesthetized dogs subjected to 30 min left anterior descending coronary artery occlusion. |
82(1,1,1,2) | Details |
| 7636745 | Danuser H, Bemis K, Thor KB: Pharmacological analysis of the noradrenergic control of central sympathetic and somatic reflexes controlling the lower urinary tract in the anesthetized cat. J Pharmacol Exp Ther. 1995 Aug;274(2):820-5. In the present study, we pharmacologically analyzed the role of noradrenergic systems on the sympathetic and somatic pathways to the lower urinary tract and asked: 1) Are alpha-1, alpha-2, or beta-adrenergic receptors tonically active along sympathetic and/or somatic reflex pathways? And 2) what is the net effect of increasing the extracellular levels of NE by administration of a NE reuptake inhibitor? To address these questions, we recorded evoked potentials from the central ends of the hypogastric and pudendal nerves in response to electrical stimulation of the pelvic and pudendal nerves in chloralose-anesthetized cats, and the effects of prazosin (1-300 micrograms/kg i.v.), an alpha-1-adrenergic receptor antagonist; idazoxan (1-300 micrograms/kg i.v.), an alpha-2-adrenergic receptor antagonist; (1 mg/kg i.v.), a beta-adrenergic receptor antagonist; and tomoxetine (0.003-3 mg/kg i.v.), a selective NE reuptake inhibitor, were examined. |
33(0,1,1,3) | Details |
| 1358421 | Penning DH, Jhamandas K: Yohimbine-precipitated clonidine withdrawal: an experimental model of the antihypertensive drug withdrawal syndrome. Can J Physiol Pharmacol. 1992 Jun;70(6):853-8. Withdrawal was precipitated by an intravenous injection of the alpha 2-adrenergic receptor antagonist yohimbine under alpha-chloralose anaesthesia, and the blood pressure and heart rate responses were recorded. |
32(0,1,1,2) | Details |
| 20211267 | Adamczak JM, Farr TD, Seehafer JU, Kalthoff D, Hoehn M: High field BOLD response to forepaw stimulation in the mouse. Neuroimage. 2010 Mar 6. To preserve neuronal activity, most fMRI experiments used alpha-chloralose to produce sedation, but severe side effects make this procedure unsuitable for survival experiments. As advantageous alternative, the alpha (2)-adrenergic receptor agonist medetomidine has been applied successfully to permit longitudinal fMRI studies in rats. |
1(0,0,0,1) | Details |
| 8750729 | Ramage AG, Wyllie MG: A comparison of the effects of doxazosin and terazosin on the spontaneous sympathetic drive to the bladder and related organs in anaesthetized cats. Eur J Pharmacol. 1995 Dec 29;294(2-3):645-50. The effects of i.v. infusion of the alpha1-adrenoceptor antagonists doxazosin and terazosin (2 mg kg-1 h-1) on spontaneous hypogastric, renal and inferior cardiac nerve activity, spontaneous bladder contractions, blood pressure, heart rate and femoral arterial flow were investigated separately in alpha-chloralose-anaesthetized cats. |
32(0,1,1,2) | Details |
| 9652366 | Farkas A, Lepran I, Papp JG: Comparison of the antiarrhythmic and the proarrhythmic effect of almokalant in anaesthetised rabbits. Eur J Pharmacol. 1998 Apr 10;346(2-3):245-53. The proarrhythmic effect of almokalant was examined during alpha1-adrenoceptor stimulation in chloralose-anaesthetised rabbits. |
7(0,0,1,2) | Details |
| 9862392 | Vacca G, Battaglia A, Ferro R, Grossini E, Mary DA, Molinari C, Surico N: The effect of distension of the uterus on plasma renin activity (PRA) in anaesthetized pigs. J Auton Nerv Syst. 1998 Nov 10;73(2-3):163-9. The same methods were used in 14 pigs which were anaesthetized with alpha-chloralose and artificially ventilated. The responses of arterial blood pressure and heart rate were respectively prevented by blockade of alpha-adrenergic receptors with phentolamine and atrial pacing. |
1(0,0,0,1) | Details |
| 11695707 | Molinari C, Battaglia A, Grossini E, Mary DA, Ruggeri P, Surico N, Vacca G, Vassanelli C: The role of activation of the renin-angiotensin system on the reflex regional vasoconstriction caused by distension of the uterus in anaesthetized pigs. Auton Neurosci. 2001 Oct 8;93(1-2):56-64. These results showed that the activation of the RAS significantly contributed to the alpha-adrenergic receptor-mediated regional vasoconstrictive responses reflexly elicited by distension of the uterus. In pigs anaesthetized with alpha-chloralose, blood flow in the left circumflex or anterior descending coronary, superior mesenteric, left renal and left external iliac arteries was assessed using electromagnetic flowmeters. |
1(0,0,0,1) | Details |
| 10415940 | Haxhiu MA, Dreshaj IA, McFadden CB, Erokwu BO, Ernsberger P: Moxonidine acting centrally inhibits airway reflex responses. Ann N Y Acad Sci. 1999 Jun 21;881:372-82. Given the presence of I1-IR sites and alpha 2-adrenergic receptors in brain regions participating in airway reflexes, these receptor classes may be involved in brainstem control of the cholinergic outflow to the airways. Experiments were performed in either alpha-chloralose anesthetized or decorticate, paralyzed, and mechanically ventilated beagle dogs. |
1(0,0,0,1) | Details |
| 9274971 | Bradley KJ, Headley PM: Effect of on spinal nociceptive reflexes: lack of interaction with alpha2-adrenoceptor or mu-opioid receptor mechanisms. Eur J Pharmacol. 1997 Jul 23;331(2-3):133-8. has been tested i.v. in alpha-chloralose anaesthetised rats for its effects on spinal nociceptive reflexes evoked by mechanical and electrical stimuli. |
1(0,0,0,1) | Details |
| 1362332 | Deschamps A, Magder S: Baroreflex control of regional capacitance and blood flow distribution with or without alpha-adrenergic blockade. Am J Physiol. 1992 Dec;263(6 Pt 2):H1755-63. Regional blood volumes (Vb), unstressed volumes (V0), blood flow distribution, venous compliances (Cv), venous resistances (Rv), and time constants of drainage (tau v) were determined in dogs anesthetized with alpha-chloralose at carotid sinus pressures (Pcs) of 50 and 200 mmHg and dosed with alpha-adrenergic or ganglionic blockade at a Pcs of 50 mmHg. In conclusion, changes in splanchnic Rv and blood flow distribution are important components of the carotid sinus reflex, and alpha-adrenergic receptor activation is only partially responsible for the changes in vascular capacitance by the baroreceptor reflex. |
1(0,0,0,1) | Details |
| 11791015 | Farkas A, Lepran I, Papp JG: Proarrhythmic effects of intravenous quinidine, amiodarone, D-sotalol, and almokalant in the anesthetized rabbit model of torsade de pointes. J Cardiovasc Pharmacol. 2002 Feb;39(2):287-97. The proarrhythmic effects of four antiarrhythmic agents were examined during alpha1-adrenoceptor stimulation in chloralose-anesthetized rabbits. |
6(0,0,1,1) | Details |
| 17382316 | Moreira TS, Takakura AC, Menani JV, Colombari E: Involvement of central alpha1- and alpha2-adrenoceptors on cardiovascular responses to moxonidine. Eur J Pharmacol. 2007 Jun 1;563(1-3):164-71. Epub 2007 Feb 16. Male Holtzman rats (n=7-8) anesthetized with urethane (0.5 g/kg, intravenously-i.v.) and alpha-chloralose (60 mg/kg, i.v.) were used. |
4(0,0,0,4) | Details |
| 1668171 | Ibricevic H, Heyeraas KJ, Pasic Juhas E, Hamamdzic M, Djordjevic N, Krnic J: Identification of alpha 2 adrenoceptors in the blood vessels of the dental pulp. Int Endod J. 1991 Nov;24(6):279-89. Using selective agonists and antagonists of alpha2 adrenoceptors, attempts were made to identify the subtype alpha2 adrenoceptors in the blood vessels of the canine dental pulp. In chloralose-anaesthetized dogs, intra-arterial administration of and guanabenz in different doses produced a dose-related pulpal vasoconstriction which was measured using -gas clearance. |
3(0,0,0,3) | Details |
| 10647770 | Shen S, Ingenito AJ: Synergistic centrally mediated cardiovascular effects of a kappa opioid agonist and an alpha2-adrenoceptor agonist. Gen Pharmacol. 1999 Dec;33(6):449-56. The drugs were microinjected at various doses into these areas of alpha-chloralose-anesthetized Sprague-Dawley rats. |
2(0,0,0,2) | Details |
| 11547128 | Chen Z, Anderson DL, Faison WL, Baer PG: Biphasic urethral sphincter responses to infusion into the lower urinary tract in anesthetized cats. J Urol. 2001 Oct;166(4):1539-48. Spinal muscarinic cholinergic and alpha-adrenergic receptors are involved in induced excitatory external urethral sphincter responses. MATERIALS AND METHODS: Bladder cystometrography and external urethral sphincter electromyography were continuously recorded in chloralose anesthetized cats. |
1(0,0,0,1) | Details |
| 8015105 | Springer JP, Kropp BP, Thor KB: Facilitatory and inhibitory effects of selective reuptake inhibitors on hypogastric nerve-evoked urethral contractions in the cat: a prominent role of urethral beta-adrenergic receptors. J Urol. 1994 Aug;152(2 Pt 1):515-9. To explore only the contribution imparted by sympathomimetic effects on the urethra by (NE) reuptake inhibition, two selective NE reuptake inhibitors (nisoxetine and tomoxetine) that possess no antimuscarinic or serotonergic properties were examined for their effects on sympathetic hypogastric nerve (HgN) evoked urethral contractions in chloralose anesthetized cats. In conclusion, these results indicate that inhibition of NE reuptake into the sympathetic nerve terminal produces a relative increase in the activation of beta adrenergic receptors compared with alpha adrenergic receptors in the urethra. |
1(0,0,0,1) | Details |
| 9436824 | Tanabe T, Usui K, Kusuzaki S, Yoshitake M, Takigawa O, Iwamoto T, Handa S: Differences in refractory-period response of canine subendocardium and subepicardium to bunazosin, an alpha1-adrenoceptor antagonist, and during myocardial ischemia. J Cardiovasc Pharmacol. 1997 Dec;30(6):824-30. Our objective was to investigate the effects of alpha1- or beta-adrenoceptor blockers on endocardial and epicardial refractory-period changes during myocardial ischemia in alpha-chloralose-anesthetized dogs. |
1(0,0,0,1) | Details |
| 12062708 | Vegh A, Parratt JR: infused locally, reduces arrhythmia severity during coronary artery occlusion in anaesthetised dogs. Cardiovasc Res. 2002 Jul;55(1):53-63. CONCLUSION: We conclude that exogenously administered NA, or released endogenously by chemical means, reduces the severity of ischaemia and reperfusion-induced ventricular arrhythmias and that this is mediated by alpha-adrenoceptors, perhaps through presynaptic inhibition of local NA release or by a 'preconditioning' effect presumably mediated by PKC. METHODS: Mongrel dogs anaesthetised with chloralose and urethane were given either (NA, 100 ng kg (-1) min (-1)), (PHE, 200 ng kg (-1) min (-1)) or isoprenaline (ISO 12.5 ng kg (-1) min (-1)) by intracoronary infusion into a side branch of the left anterior descending coronary artery (LAD), commencing 10 min prior to the occlusion and then throughout the 25-min occlusion period. |
1(0,0,0,1) | Details |
| 10813383 | Soares de Moura RS, Leao MC, Castro Resende AC, Moreira CF, Sena KM, Silveira SS, Lima AF, Nunes FR, Mesquita Ferreira AG: Actions of L-NAME and methylene blue on the hypotensive effects of clonidine and rilmenidine in the anesthetized rat. J Cardiovasc Pharmacol. 2000 May;35(5):791-5. Because activation of alpha2-adrenoceptors on endothelial cells induces release of endothelium-derived relaxing factor (EDRF), we determined whether (NO) release is involved in the antihypertensive action of clonidine and rilmenidine. In chloralose-anesthetised Wistar rats, systolic and diastolic arterial blood pressures were recorded on a polygraph. |
1(0,0,0,1) | Details |
| 8743722 | Medda BK, Koley J, Koley B: Sympathoadrenal activity in the visceral (viscerovascular) reflexes to distension of the urinary bladder. Jpn J Physiol. 1996 Feb;46(1):3-92. The experiments were performed in 37 chloralose anesthetized cats. Phentolamine, hexamethonium and guanethidine completely prevented the reflex action, and comparison of the magnitudes of responses and this inhibitory effect suggests the participation of alpha-adrenoceptors (excitatory effect) as a result of the vasoconstriction that develops during bladder distension. |
1(0,0,0,1) | Details |
| 9470149 | Vacca G, Battaglia A, Grossini E, Mary DA, Molinari C, Trevi GP: The effects of combined distension of the stomach and the descending colon on coronary blood flow in anaesthetized pigs. J Auton Nerv Syst. 1997 Dec 3;67(1-2):97-104. The effects of the combined distension of the stomach and the descending colon on coronary blood flow were examined in seven alpha-chloralose anaesthetized pigs whilst preventing changes in heart rate and aortic blood pressure. These combined responses to distension of the two viscera involved efferent sympathetic mechanisms related to alpha-adrenoceptors. |
1(0,0,0,1) | Details |
| 8901672 | Vacca G, Battaglia A, Grossini E, Mary DA, Molinari C: Reflex coronary vasoconstriction caused by gallbladder distension in anesthetized pigs. Circulation. 1996 Nov 1;94(9):2201-9. CONCLUSIONS: The present study showed that innocuous distension of the gallbladder in anesthetized pigs caused a reflex coronary vasoconstriction that involved efferent sympathetic mechanisms related to alpha-adrenoceptors and afferent vagal pathways. METHODS AND RESULTS: In 21 pigs anesthetized with pentobarbitone (16) or alpha-chloralose (5), left circumflex blood flow was measured with an electromagnetic flowmeter. |
1(0,0,0,1) | Details |
| 1666019 | Stack RK, Patterson RE: Haemodynamic effects of intracoronary neuropeptide Y in dogs: resistance to alpha adrenergic blockade. Cardiovasc Res. 1991 Sep;25(9):757-63. The purposes of this study were (a) to determine whether the vasoconstriction induced by neuropeptide Y was mediated by alpha adrenergic receptors in vivo, and (b) to determine the time course of the effect and whether it was reproducible with a second administration. EXPERIMENTAL MATERIAL: 14 mongrel dogs (n = 7 per group) were anaesthetised with chloralose for a left thoracotomy to measure coronary blood flow, aortic pressure, left ventricular pressure, and heart rate. |
1(0,0,0,1) | Details |
| 9334987 | Vacca G, Battaglia A, Grossini E, Mary DA, Molinari C, Surico N: Changes in regional blood flow in response to distension of the uterus in anaesthetised pigs. J Auton Nerv Syst. 1997 Sep 10;66(1-2):7-14. Experiments were performed in seven pigs anaesthetised with alpha-chloralose and artificially ventilated. |
0(0,0,0,0) | Details |
| 9680249 | Bootle DJ, Adcock JJ, Ramage AG: The role of central receptors in the bronchoconstriction evoked by inhaled in anaesthetised guinea-pigs. Neuropharmacology. 1998;37(2):243-50. The effects of intracisternal (i.c) injections of the 5-HT1A receptor agonists, and 8-OH-DPAT, and the antagonists WAY-100635; and (-)-pindolol, the 5-HT1B/1D receptor agonist and antagonist GR127935, the 5-HT2 receptor agonist DOI and the antagonist cinanserin, the 5-HT3 receptor antagonist granisetron, the alpha-adrenoceptor agonist clonidine and the antagonist idazoxan, the D2 receptor antagonists (-)-sulpiride and the uptake inhibitor fluoxetine on -evoked increase in tracheal inflation pressure (bronchoconstriction) were investigated in alpha-chloralose anaesthetised, neuromuscularly blocked, artificially ventilated guinea-pigs. |
0(0,0,0,0) | Details |
| 7636716 | Thor KB, Katofiasc MA: Effects of duloxetine, a combined and reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat. J Pharmacol Exp Ther. 1995 Aug;274(2):1014-24. |
0(0,0,0,0) | Details |
| 17965737 | Vincze D, Farkas AS, Rudas L, Makra P, Csik N, Lepran I, Forster T, Csanady M, Papp JG, Varro A, Farkas A: Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits. Br J Pharmacol. 2008 Jan;153(1):75-89. Epub 2007 Oct 29. Accordingly, in this study we examined the effect of pentobarbital, propofol or alpha-chloralose anaesthesia on the pro-arrhythmic activity of the class III anti-arrhythmic dofetilide in alpha (1)-adrenoceptor-stimulated rabbits. |
1(0,0,0,1) | Details |
| 7563963 | Medda BK, Koley J, Koley B: Sympathetic efferent activity in the viscerovascular reflexes induced by urinary bladder distension. Jpn J Physiol. 1995;45(2):265-77. In chloralose-anesthetized cats, rapid distension of the urinary bladder with warm (37 degrees C) normal saline (50-60 ml) causes an increase in blood pressure and contraction of the spleen. All these results with these blocking agents show that sympathetic nerves are actively involved in the reflex responses to distension of the urinary bladder with activation at the postganglionic level involving alpha-adrenoceptors and thereby the release of catecholamines. |
1(0,0,0,1) | Details |
| 8203611 | Deschamps A, Magder S: Effects of heat stress on vascular capacitance. Am J Physiol. 1994 May;266(5 Pt 2):H2122-9. To analyze these adjustments, we measured blood volumes, unstressed volumes, blood flow distribution, venous compliance, venous resistance, and the time constant of venous drainage of the splanchnic and extrasplanchnic vascular beds in dogs anesthetized with alpha-chloralose at normal and at high core temperatures. We repeated the measurements at high core temperatures with ganglionic blockade, alpha-adrenergic receptor blockade, or beta-adrenergic receptor blockade to determine the efferent neurohumoral pathway. |
1(0,0,0,1) | Details |
| 1713989 | Gayheart PA, Gwirtz PA, Bravenec JS, Longlet N, Jones CE: An alpha-adrenergic coronary constriction during esophageal distention in the dog. J Cardiovasc Pharmacol. 1991 May;17(5):747-53. This vasoconstriction was due to activation of coronary alpha-adrenergic receptors. In seven dogs anesthetized with alpha-chloralose in an open-chest procedure, the esophagus was rapidly distended to a pressure of 36 +/- 2 mm Hg, which was not significantly different from the distending pressure used in the preliminary experiments. |
1(0,0,0,1) | Details |
| 1347201 | Jones LF, Brody MJ: Characterization of coronary vasoconstriction produced by rostral ventrolateral medulla stimulation in rats. Am J Physiol. 1992 Feb;262(2 Pt 2):H437-42. Electrical stimulation of right RVLM in chloralose-anesthetized rats with bilateral vagotomy produced a transient decrease in CBF followed by an increase in CBF concomitant with a decrease in hindquarter blood flow, a pressor response, and tachycardia. These results indicate that, in rat model, the centrally induced decrease in CBF is 1) mediated by cardiac sympathetic innervation but only partially through alpha-adrenoceptors and 2) enhanced by removal of the inhibitory effect of the endothelium. |
1(0,0,0,1) | Details |