Protein Information

Name bcl 2
Synonyms Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
18069112 Lee JH, Jung JY, Jeong YJ, Park JH, Yang KH, Choi NK, Kim SH, Kim WJ: Involvement of both mitochondrial- and death receptor-dependent apoptotic pathways regulated by Bcl-2 family in sodium fluoride-induced apoptosis of the human gingival fibroblasts. Toxicology. 2008 Jan 20;243(3):340-7. Epub 2007 Nov 4.
33(0,1,1,3) Details
16388103 Xu H, Jin XQ, Jing L, Li GS: Effect of sodium fluoride on the expression of bcl-2 family and osteopontin in rat renal tubular cells. Biol Trace Elem Res. 2006 Jan;109(1):55-60.
10(0,0,1,5) Details
15842830 Xu H, Zhang JM, Zhang XY, Li GS: [Differential expression of osteopontin and bax, bcl-2 by fluoride.] . Zhonghua Yu Fang Yi Xue Za Zhi. 2005 Mar;39(2):107-10.

METHODS: The renal tubular cells were cultured and exposed to sodium fluoride (NaF) in 1, 5, 7.5, 12.5 mg F-/L level.
5(0,0,0,5) Details
11461774 Anuradha CD, Kanno S, Hirano S: Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells. Free Radic Biol Med. 2001 Aug 1;31(3):367-73.


We have reported a downregulation of Bcl-2 protein in NaF-treated cells.
1(0,0,0,1) Details
16183791 Otsuki S, Morshed SR, Chowdhury SA, Takayama F, Satoh T, Hashimoto K, Sugiyama K, Amano O, Yasui T, Yokote Y, Akahane K, Sakagami H: Possible link between glycolysis and apoptosis induced by sodium fluoride. . J Dent Res. 2005 Oct;84(10):919-23.

0(0,0,0,0) Details