| Name | extracellular signal regulated kinase 1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | sodium fluoride |
|---|---|
| CAS | sodium fluoride (NaF) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17996917 | Refsnes M, Skuland T, Schwarze PE, Ovrevik J, Lag M: -induced IL-8 release in human epithelial lung cells: relationship to EGF-receptor-, SRC- and MAP-kinase activation. Toxicol Appl Pharmacol. 2008 Feb 15;227(1):56-67. Epub 2007 Oct 3. Sodium fluoride strongly activated MAPK, in particular JNK1/2 and p38. The ERK1/2-inhibitor PD98059, the p38-inhibitor SB202190 and the JNK1/2-inhibitor SP600125 partially inhibited the -induced IL-8 response. |
4(0,0,0,4) | Details |
| 19900517 | Liu YJ, Gao Q, Wu CX, Guan ZZ: Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory. Toxicol Lett. 2010 Feb 15;192(3):324-9. Epub 2009 Nov 10. In order to reveal the mechanism of the decreased ability of learning and memory induced by chronic fluorosis, nicotinic acetylcholine receptors (nAChRs) and the pathway of extracellular signal regulated protein kinase (ERK1/2) were investigated by using the rats fed with different concentrations of sodium fluoride for 6 months. |
34(0,1,1,4) | Details |
| 11432789 | Aoki N, Aoyama K, Nagata M, Matsuda T: A growing family of dual specificity phosphatases with low molecular masses. J Biochem. 2001 Jul;130(1):133-40. The phosphatase activity of the recombinant LMW-DSPs was inhibited by orthovanadate but not sodium fluoride. However, none of the DSPs could dephosphorylate MAP kinases such as ERK1, p38, and SAPK/JNK in transiently transfected COS7 cells under the conditions used. |
1(0,0,0,1) | Details |
| 16269967 | Lappas G, Daou GB, Anand-Srivastava MB: Oxidative stress contributes to the enhanced expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells from spontaneously hypertensive rats. J Hypertens. 2005 Dec;23(12):2251-61. Similarly, diminished stimulation of adenylyl cyclase by GTPgammaS, isoproterenol and sodium fluoride in SHR was also restored towards control WKY rat levels by NAC and DPI treatments. In addition, the enhanced activity of extracellular signal-regulated kinase 1/2 in SHR as compared with WKY rats, as demonstrated by enhanced phosphorylation of extracellular signal-regulated kinase 1/2, was also restored to WKY rat levels by NAC or DPI. |
1(0,0,0,1) | Details |
| 11346645 | Aoyama K, Nagata M, Oshima K, Matsuda T, Aoki N: Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain. J Biol Chem. 2001 Jul 20;276(29):27575-83. Epub 2001 May 9. Recombinant LMW-DSP2 protein exhibited phosphatase activity toward an artificial low molecular weight substrate para-nitrophenyl and the activity was inhibited completely by orthovanadate but not sodium fluoride, and okadaic acid. |
0(0,0,0,0) | Details |