Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
7690788 Gayatri R, Chatterjee S: Phosphatase activities in pesticide-treated growing and developing cells of Dictyostelium discoideum. J Appl Toxicol. 1993 Jul-Aug;13(4):297-300.


A significant increase in acid and alkaline phosphatase activities was recorded in both growing and differentiating Dictyostelium cells treated with different doses (> or = 60 micrograms/ml) of BHC.
2(0,0,0,2) Details
16786390 Lopez L, Pozo C, Rodelas B, Calvo C, Gonzalez-Lopez J: Influence of pesticides and herbicides presence on phosphatase activity and selected bacterial microbiota of a natural lake system. Ecotoxicology. 2006 Jul;15(5):487-93.

Our data show that dissolved alkaline phosphatase was the enzymatic activity that contributed in higher proportion to total lake water samples phosphatase status.
The presence of organochlorinated insecticides (aldrin and lindane), organophosphorous insecticides (dimetoate, methidation and methyl-parathion), herbicide atrazine and fungicide captan significantly increased phosphatase activities after 28 days of incubation.
1(0,0,0,1) Details
1714421 Dikshith TS, Raizada RB, Singh V, Pandey M, Srivastava MK: Repeated dermal toxicity of technical HCH and methyl parathion (50EC) to female rats (Rattus norvigicus). Indian J Exp Biol. 1991 Feb;29(2):149-55.


Repeated dermal application of hexachlorocyclohexane (HCH; 100 mg/kg/day) or methyl parathion (2 mg/kg/day) individually or in combination for 7, 15 and 30 days produced pathomorphological changes in skin, liver, kidney and brain of female rats along with significant enzymatic alterations in the activity of transaminase, alkaline phosphatase lactic dehydrogenase and acetylcholinesterase.
1(0,0,0,1) Details
19679627 Trivedi NP, Rawal UM, Patel BP: Potency of andrographolide as an antitumor compound in BHC-induced liver damage. Integr Cancer Ther. 2009 Jun;8(2):177-89.


Serum glutamate pyruvate transaminase, serum glutamate oxalate transaminase, alkaline phosphatase, acid phosphatase, and gamma-glutamyl transpeptidase showed a significant decrease in andrographolide-supplemented animals as compared with BHC-treated animals, suggesting regenerative effects elicited by andrographolide.
1(0,0,0,1) Details
16838206 Wang F, Xu ZR, Sun JH: Effect of HCH contamination of diet on the growth performance and immune and antioxidant ability in growing/finishing pigs. Vet Res Commun. 2006 Aug;30(6):645-54.


Moreover, the activities of serum alanine aminotransferase and alkaline phosphatase were increased significantly.
1(0,0,0,1) Details
8774084 Moreno MJ, Pellicer S, Fernandez-Otero MP: Effects of different subchronic treatments with lindane on some brush border enzymes in rat jejunum. Rev Esp Fisiol. 1996 Mar;52(1):37-44.

0(0,0,0,0) Details
11811620 Labana S, Bansal RC, Mahmood A: Age related effects of organochlorine insecticide lindane on intestinal brush border membrane in rats. Indian J Biochem Biophys. 2001 Aug;38(4):249-52.

In 10 day-old suckling pups exposed to lindane, there was a significant decrease in the activities of sucrase (29%), lactase (20%) and that of alkaline phosphatase (24%) compared to control.
6(0,0,1,1) Details
17105716 Etim OE, Farombi EO, Usoh IF, Akpan EJ: The protective effect of aloe vera juice on lindane induced hepatotoxicity and genotoxicity. Pak J Pharm Sci. 2006 Oct;19(4):337-40.

Serum levels of hepatic enzyme markers: glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) were determined after oral administration of aloe vera leaves extract and lindane.
6(0,0,1,1) Details
1708667 Reddy MS, Rao KV: Aldrin and lindane impact on acid and alkaline phosphatase activities of prawn, Metapenaeus monoceros: in vitro study. Biochem Int. 1990 Dec;22(6):1033-40.
6(0,0,1,1) Details