| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | acrylonitrile |
|---|---|
| CAS | 2-propenenitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20127315 | Suhua W, Rongzhu L, Wenrong X, Guangwei X, Xiaowu Z, Shizhong W, Ye Z, Fangan H, Aschner M: Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence. Arch Toxicol. 2010 Feb 3. |
168(2,2,2,8) | Details |
| 11869835 | Thier R, Lewalter J, Selinski S, Bolt HM: Possible impact of human CYP2E1 polymorphisms on the metabolism of acrylonitrile. Toxicol Lett. 2002 Mar 10;128(1-3):249-55. |
164(2,2,2,4) | Details |
| 11535247 | Thier R, Balkenhol H, Lewalter J, Selinski S, Dommermuth A, Bolt HM: Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile. Mutat Res. 2001 Oct 1;482(1-2):41-6. |
82(1,1,1,2) | Details |
| 10563837 | Sumner SC, Fennell TR, Moore TA, Chanas B, Gonzalez F, Ghanayem BI: Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice. Chem Res Toxicol. 1999 Nov;12(11):1110-6. |
82(1,1,1,2) | Details |
| 7482528 | Subramanian U, Ahmed AE: Intestinal toxicity of acrylonitrile: in vitro metabolism by intestinal cytochrome P450 2E1. Toxicol Appl Pharmacol. 1995 Nov;135(1):1-8. |
81(1,1,1,1) | Details |
| 14644629 | Chanas B, Wang H, Ghanayem BI: Differential metabolism of acrylonitrile to is responsible for the greater sensitivity of male vs female mice: role of CYP2E1 and epoxide hydrolases. Toxicol Appl Pharmacol. 2003 Dec 1;193(2):293-302. |
36(0,1,1,6) | Details |
| 17979661 | Ghanayem BI, Hoffler U: Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using Cyp2e1 (-/-) mice. Curr Drug Metab. 2007 Oct;8(7):728-49. In particular, cytochrome P450 2E1 (CYP2E1) is implicated in the oxidative bioactivation of a variety of small hydrophobic chemicals including a number of epoxide-forming drugs and environmentally important toxicants including urethane, acrylamide, acrylonitrile, vinyl styrene, 1-bromopropane, trichloroethylene, dichloroethylene, and butadiene. |
10(0,0,1,5) | Details |
| 12690492 | Bolt HM, Roos PH, Thier R: The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. Int Arch Occup Environ Health. 2003 Apr;76(3):174-85. Epub 2003 Mar 1. |
10(0,0,0,10) | Details |
| 10215687 | Ghanayem BI, Sanders JM, Chanas B, Burka LT, Gonzalez FJ: Role of cytochrome P-450 2E1 in methacrylonitrile metabolism and disposition. J Pharmacol Exp Ther. 1999 May;289(2):1054-9. Methacrylonitrile (MAN) is a widely used aliphatic nitrile and is structurally similar to the known rat carcinogen and suspected human carcinogen acrylonitrile (AN). The objective of the present work was to determine whether CYP2E1 is involved in the oxidative metabolism of MAN as was suggested for AN. 2-14C-MAN was administered to CYP2E1-null or wild-type mice by gavage at 12 mg/kg. |
7(0,0,0,7) | Details |
| 12124309 | Wang H, Chanas B, Ghanayem BI: Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to comparative studies using CYP2E1-null and wild-type mice. Drug Metab Dispos. 2002 Aug;30(8):911-7. |
7(0,0,0,7) | Details |
| 15893539 | El Hadri L, Chanas B, Ghanayem BI: Comparative metabolism of methacrylonitrile and acrylonitrile to using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice. Toxicol Appl Pharmacol. 2005 Jun 1;205(2):116-25. Epub 2004 Nov 25. We have recently shown that CYP2E1 is essential for AN epoxidation and subsequent liberation. |
6(0,0,0,6) | Details |
| 16978761 | Emmert B, Bunger J, Keuch K, Muller M, Emmert S, Hallier E, Westphal GA: Mutagenicity of cytochrome P450 2E1 substrates in the Ames test with the metabolic competent S. typhimurium strain YG7108pin3ERb5. Toxicology. 2006 Nov 10;228(1):66-76. Epub 2006 Aug 22. In order to answer the question if CYP2E1 substrates that yield negative or inconclusive results in the Ames test can be activated by metabolic competent bacterial strains, we used YG7108pin3ERb5 to investigate the following compounds: acetamide, acrylamide, acrylonitrile, allyl ethyl acrylate, ethyl methyl-methacrylate, vinyl N-nitrosopyrrolidine, trichloroethylene and tetrachloroethylene. |
4(0,0,0,4) | Details |
| 19913070 | Guangwei X, Rongzhu L, Wenrong X, Suhua W, Xiaowu Z, Shizhong W, Ye Z, Aschner M, Kulkarni SK, Bishnoi M: pretreatment protects against acute acrylonitrile-induced oxidative damage in rats. Toxicology. 2010 Jan 12;267(1-3):140-6. Epub 2009 Nov 11. These results establish that pretreatment has a beneficial role in mitigating AN-induced oxidative stress both in the brains and livers of exposed rats and these effects are mediated independently of cytochrome P450 2E1 inhibition. |
1(0,0,0,1) | Details |
| 9598299 | Felten RK, DeNicola DB, Carlson GP: Minimal effects of acrylonitrile on pulmonary and hepatic cell injury enzymes in rats with induced cytochrome P450. Drug Chem Toxicol. 1998 May;21(2):181-94. Five agents, phenobarbital, beta-naphthoflavone, and were administered prior to AN as inducers of CYP2B, CYP1A, and CYP2E1. |
1(0,0,0,1) | Details |
| 17222524 | Pouyatos B, Gearhart C, Nelson-Miller A, Fulton S, Fechter L: Oxidative stress pathways in the potentiation of noise-induced hearing loss by acrylonitrile. Hear Res. 2007 Feb;224(1-2):61-74. Epub 2007 Jan 11. We investigated the effects of (STS), a CN inhibitor, 4-methylpyrazole (4MP), a drug that blocks CN generation by competing with CYP2E1, and l- (l-NAC), a pro-GSH drug, in order to distinguish between GSH depletion and CN production as the mechanism responsible for potentiation of NIHL by ACN. |
1(0,0,0,1) | Details |