Protein Information

Name methemoglobin
Synonyms Abnormal hemoglobin; G gamma globin; Gamma 2 globin; HBG 2; HBG2; Hb F Ggamma; Hemoglobin gamma G; Hemoglobin gamma 2 chain…

Compound Information

Name acrylonitrile
CAS 2-propenenitrile

Reference List

PubMed Abstract RScore(About this table)
9348377 Wu JS, Luttmann DR, Meininger TA, Soper NJ: Production and systemic absorption of toxic byproducts of tissue combustion during laparoscopic surgery. Surg Endosc. 1997 Nov;11(11):1075-9.

In a porcine model of laparoscopic surgery with smoke production, our aims were to assess (1) the relationship between levels of intraperitoneal carbon monoxide (CO) and systemic carboxyhemoglobin (COHb) and methemoglobin (MetHb), and (2) intraperitoneal concentrations of other noxious gases, including hydrogen cyanide (HCN), acrylonitrile (Acr), and benzene (Bzn).
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6668618 Farooqui MY, Ahmed AE: The effects of acrylonitrile on hemoglobin and red cell metabolism. . J Toxicol Environ Health. 1983 Oct-Dec;12(4-6):695-707.

GSH depletion induced oxidation of considerable amount of hemoglobin to methemoglobin.
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1965727 Farooqui MY, Mumtaz MM, Ghanayem BI, Ahmed AE: Hemoglobin degradation, lipid peroxidation, and inhibition of Na+/K (+)-ATPase in rat erythrocytes exposed to acrylonitrile. J Biochem Toxicol. 1990 Winter;5(4):221-7.

The effect of acrylonitrile (VCN) on erythrocyte lipid metabolism was investigated in vitro in metabolically active red cells from male Sprague-Dawley rats containing three types of hemoglobins: oxyhemoglobin, methemoglobin, and carbon monoxyhemoglobin.
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2100852 Proca M, Cotrau M, Butnaru E: [Biotoxicological research on a segment of the population in an industrial environment. Rev Med Chir Soc Med Nat Iasi. 1990 Apr-Jun;94(2):363-7.

Total proteins, hemoglobin, methemoglobin and cholinesterase].
This paper presents the results of a complex biochemical and biotoxicological screening including about 300 employees working at the polyplants in the melanin section where the major chemical noxa is acrylonitrile.
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