| Name | epoxide hydrolases |
|---|---|
| Synonyms | EPHX; EPHX 1; EPHX1; EPHX1 protein; EPOX; Epoxide hydratase; Epoxide hydrolase; Epoxide hydrolase 1… |
| Name | acrylonitrile |
|---|---|
| CAS | 2-propenenitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14644629 | Chanas B, Wang H, Ghanayem BI: Differential metabolism of acrylonitrile to is responsible for the greater sensitivity of male vs female mice: role of CYP2E1 and epoxide hydrolases. Toxicol Appl Pharmacol. 2003 Dec 1;193(2):293-302. |
32(0,1,1,2) | Details |
| 15893539 | El Hadri L, Chanas B, Ghanayem BI: Comparative metabolism of methacrylonitrile and acrylonitrile to using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice. Toxicol Appl Pharmacol. 2005 Jun 1;205(2):116-25. Epub 2004 Nov 25. |
32(0,1,1,2) | Details |
| 8472333 | Kedderis GL, Batra R: Species differences in the hydrolysis of 2-cyanoethylene oxide, the epoxide metabolite of acrylonitrile. Carcinogenesis. 1993 Apr;14(4):685-9. The presence of an active epoxide hydrolase hydrolysis activity toward CEO in humans should be considered in assessments of cancer risk from acrylonitrile exposure. |
8(0,0,1,3) | Details |
| 7689039 | Kim SG, Kedderis GL, Batra R, Novak RF: Induction of rat liver microsomal epoxide hydrolase by thiazole and pyrazine: hydrolysis of 2-cyanoethylene oxide. Carcinogenesis. 1993 Aug;14(8):1665-70. Epoxide hydrolase activity toward the hydrolysis of 2-cyanoethylene oxide (CEO), the epoxide metabolite of the rat carcinogen acrylonitrile, was not significant in hepatic microsomes from untreated rats, but was substantially induced by treatment with thiazole or pyrazine. |
2(0,0,0,2) | Details |
| 8035742 | Soleo L: [The detoxification pathways of electrophilic intermediate compounds] . Med Lav. 1994 Jan-Feb;85(1):22-36. The main route is the oxidative route, which uses the enzyme epoxide hydrolase. For acrylonitrile the route of conjugation with is the main detoxification route. |
1(0,0,0,1) | Details |
| 12034325 | Rossner P jr, Binkova B, Chvatalova I, Sram RJ: Acrylonitrile exposure: the effect on p53 and p21 (WAF1) protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts. Mutat Res. 2002 May 27;517(1-2):239-50. Subjects with an EPHX high activity genotype had significantly higher p21 (WAF1) expression as compared with genotypes with low or medium EPHX activity. |
1(0,0,0,1) | Details |
| 12124309 | Wang H, Chanas B, Ghanayem BI: Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to comparative studies using CYP2E1-null and wild-type mice. Drug Metab Dispos. 2002 Aug;30(8):911-7. It was hypothesized that CEO metabolism via epoxide hydrolase (EH) is the primary pathway for formation. |
1(0,0,0,1) | Details |