| Name | brains |
|---|---|
| Synonyms | BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA… |
| Name | acrylonitrile |
|---|---|
| CAS | 2-propenenitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15842835 | Lu RZ, Chen ZQ, Jin FS: [Effects of acrylonitrile in drinking water on monoamine neurotransmitters and its metabolites in male rat brains.]. Zhonghua Yu Fang Yi Xue Za Zhi. 2005 Mar;39(2):122-5. |
87(1,1,2,2) | Details |
| 10048137 | Jiang J, Xu Y, Klaunig JE: Induction of oxidative stress in rat brain by acrylonitrile (ACN). Toxicol Sci. 1998 Dec;46(2):333-41. Oxidative DNA damage indicated by the presence of (OH8dG) and lipid peroxidation indicated by the presence of malondialdehyde (MDA), a lipid peroxidation product, in rat brains and livers were examined. |
4(0,0,0,4) | Details |
| 20127315 | Suhua W, Rongzhu L, Wenrong X, Guangwei X, Xiaowu Z, Shizhong W, Ye Z, Fangan H, Aschner M: Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence. Arch Toxicol. 2010 Feb 3. The levels of (CN (-)), a terminal metabolite of AN, were significantly increased in the brains and livers of the AN-treated rats with increased CYP2E1 activity, compared with the levels in rats treated with AN alone, DCE + AN or + DCE + AN. |
2(0,0,0,2) | Details |
| 19913070 | Guangwei X, Rongzhu L, Wenrong X, Suhua W, Xiaowu Z, Shizhong W, Ye Z, Aschner M, Kulkarni SK, Bishnoi M: pretreatment protects against acute acrylonitrile-induced oxidative damage in rats. Toxicology. 2010 Jan 12;267(1-3):140-6. Epub 2009 Nov 11. These results establish that pretreatment has a beneficial role in mitigating AN-induced oxidative stress both in the brains and livers of exposed rats and these effects are mediated independently of cytochrome P450 2E1 inhibition. |
1(0,0,0,1) | Details |
| 18834918 | Campian EC, Benz FW: The acute lethality of acrylonitrile is not due to brain metabolic arrest. Toxicology. 2008 Nov 20;253(1-3):104-9. Epub 2008 Sep 9. In this study we have measured the high energy metabolites (PCr), ATP, ADP and AMP by HPLC and compared their levels in the brains of rats treated with an LD90 dose of AN, when respiration ceased, vs. controls. |
1(0,0,0,1) | Details |
| 18752313 | El-Sayed el-SM, Abo-Salem OM, Abd-Ellah MF, Abd-Alla GM: an antioxidant prevents acrylonitrile-induced oxidative stress in rat brain. J Biochem Mol Toxicol. 2008 Jul;22(4):268-73. We examined the ability of an antioxidant to attenuate ACN-induced alterations in lipid peroxidation in rat brains. |
1(0,0,0,1) | Details |
| 2425936 | Hogy LL, Guengerich FP: In vivo interaction of acrylonitrile and 2-cyanoethylene oxide with DNA in rats. Cancer Res. 1986 Aug;46(8):3932-8. |
0(0,0,0,0) | Details |