| Name | p21 protein |
|---|---|
| Synonyms | C H RAS; Transforming protein p21; N ras; HRAS1; HRASP; C H ras 1 protein N terminal fragment (37 AA); C has/bas p21 protein; C ras Ki 2 protein… |
| Name | acrylonitrile |
|---|---|
| CAS | 2-propenenitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1903090 | Yuan B, Wong JL: Inactivity of acrylonitrile epoxide to modify a Ha-ras DNA in a non-focus transfection-transformation assay. Carcinogenesis. 1991 May;12(5):787-91. |
82(1,1,1,2) | Details |
| 10451498 | Didenko VV, Wang X, Yang L, Hornsby PJ: DNA damage and p21 (WAF1/CIP1/SDI1) in experimental injury of the rat adrenal cortex and trauma-associated damage of the human adrenal cortex. J Pathol. 1999 Sep;189(1):119-26. These interventions comprised ischaemia and reperfusion injury, sepsis following caecal ligation and puncture, acute pancreatitis, and administration of chemical agents (zymosan and acrylonitrile). Increased nuclear p21 protein was shown by immunohistochemistry. |
1(0,0,0,1) | Details |
| 12562636 | Melnick RL: Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals. Ann N Y Acad Sci. 2002 Dec;982:177-89. Several of these chemicals were demonstrated to be carcinogenic in laboratory animal studies conducted by the Ramazzini Foundation (e.g., vinyl acrylonitrile, styrene, styrene oxide, and and by the National Toxicology Program (e.g., ethylene oxide, 1,3-butadiene, isoprene, chloroprene, acrylonitrile, glycidol, and N7-Alkylguanine, N1-alkyladenine, and cyclic etheno adducts, as well as K-ras and p53 mutations, have been detected in animals and/or workers exposed to several of these chemicals. |
1(0,0,0,1) | Details |
| 10698723 | Sram RJ, Binkova B: Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999. Environ Health Perspect. 2000 Mar;108 Suppl 1:57-70. Biomarkers evaluated were selected according to basic scheme: biomarkers of exposure--metabolites in urine, DNA adducts, protein adducts, and Comet assay parameters; biomarkers of effect--chromosomal aberrations, sister chromatid exchanges, micronuclei, mutations in the hypoxanthine-guanine phosphoribosyltransferase gene, and the activation of oncogenes coding for p53 or p21 proteins as measured on protein levels; biomarkers of susceptibility--genetic polymorphisms of genes CYP1A1, GSTM1, GSTT1, NAT2. Protein adducts are useful as a biomarker for exposure to tobacco smoke (4-aminobiphenyl) or to smaller molecules such as acrylonitrile or 1,3-butadiene. |
1(0,0,0,1) | Details |