| Name | glucagon |
|---|---|
| Synonyms | GCG; GLP 1; GLP1; GLP 2; GLP2; GRPP; Glicentin related polypeptide; Glucagon… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8946334 | Nishizawa M, Nakabayashi H, Uchida K, Nakagawa A, Niijima A: The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-1, but not to glucose-dependent insulinotropic polypeptide, in the portal vein. J Auton Nerv Syst. 1996 Nov 6;61(2):149-54. To examine whether incretin hormones, truncated glucagon-like peptide-1 (tGLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are recognized by the hepatic vagal nerve, changes of the impulse discharge rate in the afferent vagus upon their intraportal administrations were measured in situ in rats anesthetized with urethan and chloralose. |
31(0,1,1,1) | Details |
| 7611388 | Krowicki ZK, Hornby PJ: The nucleus raphe obscurus controls pancreatic hormone secretion in the rat. Am J Physiol. 1995 Jun;268(6 Pt 1):E1128-34. Kainic acid and vehicle were microinjected into the right DVC and the NRO of alpha-chloralose-anesthetized rats, and plasma concentrations of rat insulin, glucagon, and were determined before and 5, 15, 30, and 60 min after injections. |
8(0,0,1,3) | Details |
| 7823413 | Kurosawa M, Nagai N, Sato A, Uvnas-Moberg K: Somatic afferent regulation of plasma immunoreactive glucagon in anesthetized rats. Jpn J Physiol. 1994;44(3):221-30. Experiments were performed using chloralose- and urethane-anesthetized rats, ventilated artificially. |
5(0,0,0,5) | Details |
| 11882507 | Deacon CF, Plamboeck A, Moller S, Holst JJ: GLP-1-(9-36) amide reduces blood in anesthetized pigs by a mechanism that does not involve insulin secretion. Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E873-9. Glucagon-like peptide 1 (GLP-1) is a potent anti-hyperglycemic hormone currently under investigation for its therapeutic potential. In chloralose-anesthetized pigs given -pyrrolidide (to block endogenous DPP IV activity), the independent effects of GLP-1-(7-36) amide on and insulin responses to intravenous were assessed, and the metabolite generated by DPP IV, GLP-1-(9-36) amide, was investigated for any ability to influence these responses. |
2(0,0,0,2) | Details |
| 8246150 | Kline JA, Tomaszewski CA, Schroeder JD, Raymond RM: Insulin is a superior antidote for cardiovascular toxicity induced by in the anesthetized canine. J Pharmacol Exp Ther. 1993 Nov;267(2):744-50. Because of its positive inotropic effects that are independent of cyclic AMP, insulin was compared to and glucagon as a novel treatment for cardiac toxicity from Twenty-four alpha-chloralose-anesthetized mongrel canines of either sex were instrumented to monitor standard hemodynamic and cardiodynamic parameters and maximum elastance at end systole, via the -time technique, as our index of contractility. |
3(0,0,0,3) | Details |
| 7600835 | Kline JA, Leonova E, Raymond RM: Beneficial myocardial metabolic effects of insulin during toxicity in the anesthetized canine. Crit Care Med. 1995 Jul;23(7):1251-63. INTERVENTIONS: Thirty mongrel canines were anesthetized with alpha-chloralose. Animals (n = 6 per group) were randomized to the control group (saline only) or to one of four treatment protocols: a) calcium chloride (20 mg/kg), then 0.6 mg/kg/hr; b) hyperinsulinemia-euglycemia (4.0 U/min of recombinant insulin, with arterial concentration clamped to +/- 10 mg/dL [+/- 0.5 mmol/L] of the basal value); c) with a starting rate of 1.0 microgram/kg/min, titrated to maintain left ventricular pressure at basal values; or d) glucagon, a 0.2-mg/kg bolus, followed by a 150-microgram/kg/hr infusion. |
2(0,0,0,2) | Details |
| 15475512 | Hansen L, Lampert S, Mineo H, Holst JJ: Neural regulation of glucagon-like peptide-1 secretion in pigs. Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E939-47. In chloralose-anesthetized pigs, however, electrical stimulation of the vagal trunks at the level of the diaphragm had no effect on GLP-1 or GLP-2 and weak effects on -dependent insulinotropic peptide and somatostatin secretion, although this elicited a marked atropine-resistant release of the neuropeptide vasoactive intestinal polypeptide to the portal circulation. |
2(0,0,0,2) | Details |
| 16608883 | Deacon CF, Plamboeck A, Rosenkilde MM, de Heer J, Holst JJ: GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations. Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E468-75. Epub 2006 Apr 11. insulin, and glucagon responses were identical irrespective of whether GIP-(1-42) was infused alone or together with GIP-(3-42). The ability of GIP-(3-42) to affect the antihyperglycemic or insulinotropic actions of GIP-(1-42) was examined in chloralose-anesthetized pigs given intravenous |
1(0,0,0,1) | Details |
| 8944665 | Nakabayashi H, Nishizawa M, Nakagawa A, Takeda R, Niijima A: Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am J Physiol. 1996 Nov;271(5 Pt 1):E808-13. Among proglucagon-derived peptides, the truncated form of glucagon-like peptide-1, GLP-1 (7-36) amide (tGLP-1), is known as the most likely physiological humoral incretin. To examine whether there exists any relationship between tGLP-1 levels in the portal vein and activities of the hepatic and pancreatic vagal system, changes of the impulse discharge rate in the hepatic afferent vagus and the pancreatic efferent vagus upon intraportal tGLP-1 injection were measured in situ in rats anesthetized with urethan and chloralose. |
1(0,0,0,1) | Details |
| 7485582 | Hill MR, Wallick DW, Mongeon LR, Martin PJ, Levy MN: Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog. Am J Physiol. 1995 Oct;269(4 Pt 2):H1467-72. We used three vasoactive intestinal polypeptide (VIP) antagonists, VIP-(10-28), [p-Cl-D-Phe6,Leu17] VIP, and NT-VIP, to evaluate the role of VIP as a mediator of vagally induced tachycardia in chloralose-anesthetized dogs. We tested the specificity of these VIP antagonists by determining whether they attenuated the increases in heart rate evoked by two other neuropeptides [peptide histidine (PHI) and glucagon]. |
1(0,0,0,1) | Details |