| Name | AT1 |
|---|---|
| Synonyms | AG2S; AT1; AGTR 1; AGTR1; AGTR1A; AGTR1B; AT1AR; AT1B… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7485604 | Stebbins CL, Bonigut S: Spinal angiotensin II influences reflex cardiovascular responses to muscle contraction. Am J Physiol. 1995 Oct;269(4 Pt 2):R864-8. Consequently, in alpha-chloralose-anesthetized cats, contraction-induced increases in mean arterial blood pressure, maximal rate of rise in left ventricular pressure (dP/dt), and heart rate were compared before and after intrathecal injection of the AT1 receptor antagonist losartan (100 or 1,000 micrograms; n = 7). |
32(0,1,1,2) | Details |
| 16099221 | Wang HJ, Zhang F, Zhang Y, Gao XY, Wang W, Zhu GQ: AT1 receptor in paraventricular nucleus mediates the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Auton Neurosci. 2005 Aug 31;121(1-2):56-63. Under urethane and alpha-chloralose anesthesia, mean arterial pressure, heart rate and renal sympathetic nerve activity (RSNA) were recorded in sino-aortic denervated and cervical vagotomized CHF and sham-operated rats. |
7(0,0,0,7) | Details |
| 14576548 | Baranov D, Armstead WM: Selective blockade of AT1 receptor attenuates impairment of hypotensive autoregulation and improves cerebral blood flow after brain injury in the newborn pig. Anesthesiology. 2003 Nov;99(5):1118-24. METHODS: Fluid percussion injury was induced in chloralose-anesthetized newborn pigs equipped with closed cranial windows. |
6(0,0,0,6) | Details |
| 12689346 | Ewert S, Laesser M, Johansson B, Holm M, Aneman A, Fandriks L: The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa. BMC Pharmacol. 2003 Mar 4;3:2. Epub 2003 Mar 4. BACKGROUND: This study was conducted to elucidate if is released by the porcine jejunal mucosa upon selective stimulation of AT2 receptors and the possible involvement of iNOS, and to investigate the presence of jejunal AT1 and AT2 receptors. Young landrace pigs were anaesthetized with ketamine and alpha-chloralose. |
4(0,0,0,4) | Details |
| 15897358 | Gao L, Schultz HD, Patel KP, Zucker IH, Wang W: Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure. Hypertension. 2005 Jun;45(6):1173-81. Epub 2005 May 16. Therefore, the hypothesis is that the augmented CSAR in the CHF state tonically inhibits the baroreflex via central AT1 receptor. To test the hypothesis, the rats with myocardial infarction-induced CHF or sham surgery were anesthetized with alpha-chloralose and urethane, vagotomized, and recordings were made of the mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA). |
2(0,0,0,2) | Details |
| 8713681 | Chai CY, Chen SY, Lin AM, Tseng CJ: Angiotensin II activates pressor and depressor sites of the pontomedulla that react to Clin Exp Pharmacol Physiol. 1996 May;23(5):415-23. In cats anaesthetized with a mixture of alpha-chloralose (40 mg/kg) and urethane (400 mg/kg) and in rats anaesthetized with a mixture of alpha-chloralose (60 mg/kg) and urethane (800 mg/kg), changes in systemic arterial pressure (SAP), heart rate (HR) and sympathetic activities of vertebral (VNA) and renal (RNA) nerves were determined following the microinjection of angiotensin II (AngII; 0.16 mmol/L; 50 nL) into the pressor and depressor sites of the pontomedulla previously reacted to a microinjection of monosodium 0.1 mol/L; 50 nL). The effects of losartan (1 mmol/L; 50 nL), a specific AT1 receptor non-peptide antagonist for AngII, on responses induced by AngII in the VLM, DM and CVLM were also determined. 2. |
1(0,0,0,1) | Details |
| 12111042 | Zhu GQ, Zucker IH, Wang W: Central AT1 receptors are involved in the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Basic Res Cardiol. 2002 Jul;97(4):320-6. Under alpha-chloralose and urethane anesthesia, mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) were recorded in sino-aortic denervated and cervical vagotomized rats. |
1(0,0,0,1) | Details |
| 12623990 | Ito S, Hiratsuka M, Komatsu K, Tsukamoto K, Kanmatsuse K, Sved AF: Ventrolateral medulla AT1 receptors support arterial pressure in Dahl salt-sensitive rats. Hypertension. 2003 Mar;41(3 Pt 2):744-50. Epub 2003 Jan 20. Rats were anesthetized with alpha-chloralose, and the effects of microinjecting the AT1R antagonist valsartan (Val) or angiotensin II (Ang II) into the RVLM on MAP were measured. |
1(0,0,0,1) | Details |
| 15243307 | Gautier P, Guillemare E, Djandjighian L, Marion A, Planchenault J, Bernhart C, Herbert JM, Nisato D: In vivo and in vitro characterization of the novel antiarrhythmic agent SSR149744C: electrophysiological, anti-adrenergic, and anti-angiotensin II effects. J Cardiovasc Pharmacol. 2004 Aug;44(2):244-57. In chloralose-anesthetized dogs, SSR149744C (1-10 mg/kg i.v.) prolonged the sinus cycle length, A-H interval, Wenckebach cycle length, atrial effective refractory period (ERP), and atrio-ventricular node ERP in a dose-dependent manner without change of ventricular ERP and HV, QRS, or QTc intervals. Therefore, SSR149744C appears to have a multifactorial mechanism of action, which combines the blockade of several ion channels with the inhibition of responses of alpha 1 and beta 1 adrenergic as well as AT1 receptor stimulation. |
1(0,0,0,1) | Details |
| 15475555 | Zhu GQ, Gao L, Patel KP, Zucker IH, Wang W: ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. J Appl Physiol. 2004 Nov;97(5):1746-54. Under alpha-chloralose and urethane anesthesia, renal sympathetic nerve activity (RSNA) was recorded. |
0(0,0,0,0) | Details |