Protein Information

Name adenosine A1 receptors
Synonyms A1AR; ADORA 1; ADORA1; Adenosine A1 receptor; RDC 7; RDC7; Adenosine A1 receptors

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
8789379 St Lambert JH, Dashwood MR, Spyer KM: Role of brainstem adenosine A1 receptors in the cardiovascular response to hypothalamic defence area stimulation in the anaesthetized rat. Br J Pharmacol. 1996 Jan;117(2):277-82.

The role of centrally located adenosine A1 receptors in the cardiovascular changes associated with the hypothalamic defence response has been investigated by in vitro autoradiography and the intraventricular application of an A1 receptor antagonist. 2. 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX), a highly selective adenosine A1 antagonist and its vehicle, ethanol, were administered directly into the posterior portion of the fourth ventricle of alpha-chloralose anaesthetized, paralysed and artificially ventilated rats. 3.
33(0,1,1,3) Details
12023327 Goadsby PJ, Hoskin KL, Storer RJ, Edvinsson L, Connor HE: Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission. Brain. 2002 Jun;125(Pt 6):1392-401.

Cats were anaesthetized (alpha-chloralose 60 mg/kg, intraperitoneally), and prepared for physiological monitoring.
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15539419 Scislo TJ, Tan N, O'Leary DS: Differential role of nitric oxide in regional sympathetic responses to stimulation of NTS A2a adenosine receptors. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H638-49. Epub 2004 Nov 11.

Our previous studies showed that preganglionic adrenal (pre-ASNA), renal (RSNA), lumbar, and postganglionic adrenal sympathetic nerve activities (post-ASNA) are inhibited after stimulation of arterial baroreceptors, nucleus of the solitary tract (NTS), and glutamatergic and P2x receptors and are activated after stimulation of adenosine A1 receptors.
Therefore, in chloralose/urethane-anesthetized rats, we compared hemodynamic and regional sympathetic responses to microinjections of selective A2a receptor agonist (CGS-21680, 20 pmol/50 nl) after pretreatment with NOS inhibitors Nomega-nitro-L-arginine methyl ester (10 nmol/100 nl) and 1-[2-(trifluoromethyl) phenyl] imidazole (100 pmol/100 nl) versus pretreatment with vehicle (100 nl).
1(0,0,0,1) Details
15893424 Ramos-Zepeda G, Herrero JF: Enhancement of wind-up by the combined administration of adenosine A1 receptor ligands on spinalized rats with carrageenan-induced inflammation. Neurosci Lett. 2005 Aug 12-19;384(1-2):177-82.

The experiments were carried out in spinalized male Wistar rats under alpha-chloralose anaesthesia.
1(0,0,0,1) Details
11668063 Meno JR, Crum AV, Winn HR: Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. Am J Physiol Heart Circ Physiol. 2001 Nov;281(5):H2018-27.

The pial circulation was observed through a closed cranial window in alpha-chloralose-anesthetized rats.
Topical superfusion of 8- cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist, significantly potentiated SNS-induced vasodilatation (P < 0.01; n > or = 5).
1(0,0,0,1) Details