Protein Information

Name KGFR
Synonyms BEK; Hydroxyaryl protein kinase; Tyrosylprotein kinase; CFD1; BEK fibroblast growth factor receptor; BFR 1; BFR1; Bacteria expressed kinase…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
17662249 Antoine M, Wirz W, Tag CG, Gressner AM, Marvituna M, Wycislo M, Hellerbrand C, Kiefer P: Expression and function of fibroblast growth factor (FGF) 9 in hepatic stellate cells and its role in toxic liver injury. Biochem Biophys Res Commun. 2007 Sep 21;361(2):335-41. Epub 2007 Jul 24.

Expression of FGF9, known to be capable to activate the HSC FGFR2/3-isoforms, was increased in HSC in liver slice cultures after exposition to carbon tetrachloride, as an acute liver injury model.
31(0,1,1,1) Details
16228231 Ishikawa T, Terai S, Urata Y, Marumoto Y, Aoyama K, Sakaida I, Murata T, Nishina H, Shinoda K, Uchimura S, Hamamoto Y, Okita K: Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res. 2006 Feb;323(2):221-31. Epub 2005 Oct 14.

We have developed an in vivo mouse model, the green fluorescent protein (GFP)/carbon tetrachloride (CCl (4)) model, and have previously reported that transplanted GFP-positive bone marrow cells (BMCs) differentiate into hepatocytes via hepatoblast intermediates.
In liver samples, the expression of FGF1 and FGF2 and of FGF receptors (FGFRs; FGFR1, FGFR2) was significantly elevated with time after bone marrow transplantation (BMT) compared with other factors, and co-expression of GFP and FGFs or FGFRs could be detected.
1(0,0,0,1) Details
17692400 Otte JM, Schwenger M, Brunke G, Schmitz F, Otte C, Kiehne K, Kloehn S, Monig H, Schmidt WE, Herzig KH: Differential regulated expression of keratinocyte growth factor and its receptor in experimental and human liver fibrosis. Regul Pept. 2007 Dec 4;144(1-3):82-90. Epub 2007 Jul 3.

METHODS: Liver fibrosis and cirrhosis was induced in rats by repetitive exposure to phenobarbitone and increasing doses of carbon tetrachloride.
Expression of KGF and its receptor (KGFR) mRNA was quantified by real-time RT-PCR.
4(0,0,0,4) Details
16025519 Tsui TY, Lau CK, Ma J, Wu X, Wang YQ, Farkas S, Xu R, Schlitt HJ, Fan ST: rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats. Hepatology. 2005 Aug;42(2):335-42.

Portal injection of rAAVs to normal or carbon tetrachloride (CCl (4))-induced liver fibrosis showed a distinct distribution of rAAV binding.
The majority of injected rAAVs bound to the cells in fibrotic areas that were associated with higher expression levels of fibroblast growth factor receptor-1alpha at 2 hours after administration.
1(0,0,0,1) Details