| Name | angiotensin II |
|---|---|
| Synonyms | AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19641881 | Choi JH, Shin S, Park D, Jeon JH, Choi BH, Jang MJ, Joo SS, Oh KW, Hong JT, Suh KH, Kim YB: Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction. Arch Pharm Res. 2009 Jul;32(7):1005-11. Epub 2009 Jul 31. Male Wistar rats were intraperitoneally injected with 0.5 mL/kg of carbon tetrachloride to cause hepatic injury, and implanted with an osmotic minipump containing angiotensin II (0.4 mg/kg/day) to induce hypertension. |
8(0,0,1,3) | Details |
| 16774739 | Nabeshima Y, Tazuma S, Kanno K, Hyogo H, Iwai M, Horiuchi M, Chayama K: Anti-fibrogenic function of angiotensin II type 2 receptor in CCl4-induced liver fibrosis. Biochem Biophys Res Commun. 2006 Aug 4;346(3):658-64. Epub 2006 Jun 8. A comparison was made between AT2-receptor knockout (AT2KO) and wild type (WT) mice after 4 weeks of treatment with carbon tetrachloride (CCl4). |
3(0,0,0,3) | Details |
| 15573910 | Wei YH, Jun L, Qiang CJ: Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats. Dig Dis Sci. 2004 Oct;49(10):1589-94. |
3(0,0,0,3) | Details |
| 15244070 | Nie L, Imamura M, Itoh H, Ueno H: Pitavastatin enhances the anti-fibrogenesis effects of candesartan, an angiotensin II receptor blocker, on CCl4-induced liver fibrosis in rats. J UOEH. 2004 Jun 1;26(2):165-77. In this study, we tested whether a combinatory use of a (pitavastatin) and an ARB (candesartan) may further inhibit liver fibrogenesis in carbon tetrachloride (CCl4)-treated rats. |
2(0,0,0,2) | Details |
| 19056767 | Moreno M, Ramalho LN, Sancho-Bru P, Ruiz-Ortega M, Ramalho F, Abraldes JG, Colmenero J, Dominguez M, Egido J, Arroyo V, Gines P, Bataller R: attenuates angiotensin II-induced inflammatory actions in the liver. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G147-56. Epub 2008 Dec 4. The beneficial effects of were confirmed in an additional model of acute liver injury (carbon tetrachloride administration). |
2(0,0,0,2) | Details |
| 14761280 | Li X, Meng Y, Yang XS, Zhang ZS, Wu PS, Zou JL: [Perindopril attenuates the progression of CCl4-inducing rat hepatic fibrosis]. Zhonghua Gan Zang Bing Za Zhi. 2004 Jan;12(1):32-4. RT-PCR was utilized to detect gene expression of angiotensin II type 1 receptor (AT1 receptor) in the liver. |
2(0,0,0,2) | Details |
| 16097048 | Li X, Meng Y, Yang XS, Mi LF, Cai SX: ACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-beta1, PDGF-BB, NF-kappaB and MMP-2,9. World J Gastroenterol. 2005 Aug 21;11(31):4807-11. AIM: Angiotensin II has pro-fibrotic function in the liver. |
1(0,0,0,1) | Details |
| 16872305 | Xu W, Song S, Huang Y, Gong Z: Effects of perindopril and valsartan on expression of transforming growth factor-beta-Smads in experimental hepatic fibrosis in rats. J Gastroenterol Hepatol. 2006 Aug;21(8):1250-6. The aim of this study was to investigate the effect and mechanism of an angiotensin-converting enzyme inhibitor (perindopril) and an angiotensin II receptor blocker (valsartan) on TGF-beta1 and TGF receptor II (TRII) mRNA, Smad3 and Smad7 in fibrotic hepatic livers in rats. METHODS: Sixty Wistar rats were randomly divided into four study groups (n = 15 for each group), including normal controls, hepatic fibrosis models, and two treated groups with either perindopril or valsartan, starting from the fourth week after being exposed to carbon tetrachloride (CCl (4)) for 4 weeks. |
1(0,0,0,1) | Details |
| 19650157 | Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA: Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep;50(3):929-38. HSCs express the Ang (1-7) receptor Mas and Ang (1-7) inhibited Ang II-induced phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 in cultured HSCs. Ace2 KO mice showed increased liver fibrosis following bile duct ligation for 21 days or chronic carbon tetrachloride (CCl (4)) treatment. |
1(0,0,0,1) | Details |
| 16635309 | Yang L, Qian W, Hou XH, Xu KS, Wang JP: [Effects of extracts of Rhizoma curcumae on angiotensin II and its type 1 receptor expression in rat liver fibrosis induced by CCl4] Zhonghua Gan Zang Bing Za Zhi. 2006 Apr;14(4):303-5. |
1(0,0,0,1) | Details |
| 15619341 | Gong ZJ, Song SL, Huang YQ, Ruan P: [Effects of perindopril and valsartan on the expression of TGF beta 1 and TGF beta receptor II mRNA, Smad3 and Smad7 in experimental hepatic fibrotic rats]. Zhonghua Gan Zang Bing Za Zhi. 2004 Dec;12(12):737-40. OBJECTIVE: To investigate the therapeutic effects of perindopril, an angiotensin-converting enzyme inhibitor, and valsartan, an angiotensin II receptor blocker on TGFbeta1 and TGFbeta receptor II mRNA, Smad3 and Smad7 on rat liver fibrosis. |
1(0,0,0,1) | Details |