| Name | microRNA |
|---|---|
| Synonyms | MIRN410; hsa mir 410; microRNA; hsa mir 410s; microRNAs |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17965554 | Fukushima T, Hamada Y, Yamada H, Horii I: Changes of micro-RNA expression in rat liver treated by or carbon tetrachloride--regulating role of micro-RNA for RNA expression. 714.e1-4. Epub 2009 Oct 17. Recently, microRNAs, involved in RNA interference, were discovered as a new gene regulation, with little is known in the filed of toxicology. |
9(0,0,0,9) | Details |
| 19674103 | Guo CJ, Pan Q, Cheng T, Jiang B, Chen GY, Li DG: Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. J Toxicol Sci. 2007 Oct;32(4):401-9. |
2(0,0,0,2) | Details |
| 19843474 | Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA: MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology. 2010 Feb;138(2):705-14 MeCP2 (-/y) mice and an inhibitor (DZNep) of the epigenetic regulatory protein EZH2 were used in the carbon tetrachloride model of liver fibrosis. Reverse transcription PCR detected changes in expression of the microRNA miR132 and its target, elongated transcripts of MeCP2. |
1(0,0,0,1) | Details |
| 19844192 | Beer S, Bellovin DI, Lee JS, Komatsubara K, Wang LS, Koh H, Borner K, Storm TA, Davis CR, Kay MA, Felsher DW, Grimm D: Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice. FEBS J. 2009 Sep;276(18):5163-76. Epub 2009 Aug 10. Surprisingly, various irrelevant control shRNAs similarly induced a rapid onset of tumorigenesis, comparable to carbon tetrachloride (CCl4), a potent carcinogen. Moreover, we noted that shRNA expression globally dysregulated hepatic microRNA (miRNA) expression, and that shRNA levels and activity further increased in the presence of MYC. |
1(0,0,0,1) | Details |