Protein Information

Name PPAR delta
Synonyms FAAR; NR1C2; NUC 1; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; PPAR beta…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
18622026 Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM: Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci. 2008 Oct;105(2):418-28. Epub 2008 Jul 12.
41(0,1,2,6) Details
18038451 Shan W, Nicol CJ, Ito S, Bility MT, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM: Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice. Hepatology. 2008 Jan;47(1):225-35.

Exacerbated carbon tetrachloride (CCl (4)) hepatoxicity was also observed in PPARbeta/delta-null as compared with wild-type mice.
11(0,0,1,6) Details
19144177 Marsillach J, Camps J, Ferre N, Beltran R, Rull A, Mackness B, Mackness M, Joven J: Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease. BMC Gastroenterol. 2009 Jan 14;9:3.

2(0,0,0,2) Details