| Name | CD4 |
|---|---|
| Synonyms | CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18361832 | Li J, Cheng LF, Li Z, Cong YW: [Intestinal intraepithelial lymphocytes in cirrhosis: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2008 Jan 22;88(4):233-5. METHODS: Forty Wistar rats were randomly divided into 2 groups: cirrhosis group (n = 25) undergoing subcutaneous injection of 40% carbon tetrachloride twice a week for 10-12 weeks to establish cirrhosis models, and control group (n = 15). The T lymphocytes in the intestinal epithelium were isolated and labeled with mouse anti-rat CD3, CD4 and CD8 monoclonal antibody, Flow cytometry was performed. |
4(0,0,0,4) | Details |
| 15362042 | Safadi R, Ohta M, Alvarez CE, Fiel MI, Bansal M, Mehal WZ, Friedman SL: Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology. 2004 Sep;127(3):870-82. METHODS: We generated transgenic (TG) mice with hepatocyte expression of rat IL-10 (rIL-10) to assess its impact on lymphocyte subsets and activation of hepatic stellate cells following liver injury from carbon tetrachloride (CCl 4 ) or thioacetamide (TAA). By fluorescence-activated cell sorter (FACS), there were less CD4+ T cells in naive TG mice, and, following fibrosis induction, CD4+ T cells decreased only in wild-type (WT) mice, whereas increases in CD8+ T cells seen in WT animals were significantly attenuated in TG mice. |
2(0,0,0,2) | Details |
| 17038628 | Horani A, Muhanna N, Pappo O, Melhem A, Alvarez CE, Doron S, Wehbi W, Dimitrios K, Friedman SL, Safadi R: Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G628-38. Epub 2006 Oct 12. Fibrosis induction was associated with significant increase in CD8 subsets and decrease in CD4 T cells. Hepatic fibrosis was induced in C57BL/6 mice by intraperitoneal administration of carbon tetrachloride (CCl (4)) for 6 wk. |
3(0,0,0,3) | Details |
| 17437422 | Muhanna N, Horani A, Doron S, Safadi R: Lymphocyte-hepatic stellate cell proximity suggests a direct interaction. . Clin Exp Immunol. 2007 May;148(2):338-47. Although the number of all liver lymphocyte subsets increased following fibrosis induction, FACS analysis revealed an increase in the distribution of liver CD8 subsets and a decrease of CD4 T cells. To investigate lymphocyte/hepatic stellate cell (HSC) interactions, hepatic fibrosis was induced by administering carbon tetrachloride (CCl4) intraperitoneally (i.p.) for 4 weeks in C57Bl/6 mice. |
2(0,0,0,2) | Details |
| 17412915 | Amatucci A, Novobrantseva T, Gilbride K, Brickelmaier M, Hochman P, Ibraghimov A: Recombinant ST2 boosts hepatic Th2 response in vivo. J Leukoc Biol. 2007 Jul;82(1):124-32. Epub 2007 Apr 5. We addressed the impact of the ST2 pathway on fibrogenesis using a mouse model of hepatic injury and fibrosis induced by carbon tetrachloride (CCl (4)). Moreover, depletion of CD4 (+) T cells abrogated ST2-Fc-enhanced Th2 cytokines and accelerated fibrosis. |
2(0,0,0,2) | Details |
| 18340409 | Abu-Rizq HA, Mansour MH, Safer AM, Afzal M: Cyto-protective and immunomodulating effect of longa in Wistar rats subjected to carbon tetrachloride-induced oxidative stress. Inflammopharmacology. 2008 Apr;16(2):87-95. A selective cytolytic effect of CCl4 was observed among immature (PNA+) thymocytes and peripheral helper (CD4+) T lymphocytes in spleen and was paralleled by a significant reduction in CD25, CD71 and Con A receptor expression. |
2(0,0,0,2) | Details |
| 16276407 | Bhogal RK, Bona CA: B cells: no longer bystanders in liver fibrosis. . J Clin Invest. 2005 Nov;115(11):2962-5. The contribution of CD4+ Th2 cells to hepatic fibrosis has been well described. In a carbon tetrachloride-induced mouse model of hepatic fibrosis, T cell-deficient mice developed severe liver fibrosis; however, in B cell-deficient animals, hepatic fibrosis was attenuated. |
1(0,0,0,1) | Details |
| 16527836 | Frelin L, Brenndorfer ED, Ahlen G, Weiland M, Hultgren C, Alheim M, Glaumann H, Rozell B, Milich DR, Bode JG, Sallberg M: The hepatitis C virus and immune evasion: non-structural 3/4A transgenic mice are resistant to lethal tumour necrosis factor alpha mediated liver disease. Gut. 2006 Oct;55(10):1475-83. Epub 2006 Mar 9. Liver damage was induced using carbon tetrachloride (CCl (4)), lipopolysaccaride (LPS), tumour necrosis factor alpha (TNFalpha), and anti-Fas antibody. |
0(0,0,0,0) | Details |