Protein Information

Name ADAMTS 13
Synonyms A disintegrin and metalloproteinase with thrombospondin motifs 13; TTP; ADAM TS 13; ADAM TS13; ADAMTS 13; ADAMTS 13 precursor; ADAMTS13; UNQ6102/PRO20085…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
17383642 Kume Y, Ikeda H, Inoue M, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ichikawa T, Kaneko M, Okubo S, Yokota H, Omata M, Fujiwara K, Yatomi Y: Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats. FEBS Lett. 2007 Apr 17;581(8):1631-4. Epub 2007 Mar 20.

Plasma ADAMTS13 activity was markedly reduced in dimethylnitrosamine-treated rats, where HSC apoptosis is an essential event, but not in carbon tetrachloride- or thioacetamide-treated rats without HSC apoptosis.
4(0,0,0,4) Details
18042797 Miyata E, Masuya M, Yoshida S, Nakamura S, Kato K, Sugimoto Y, Shibasaki T, Yamamura K, Ohishi K, Nishii K, Ishikawa F, Shiku H, Katayama N: Hematopoietic origin of hepatic stellate cells in the adult liver. . Blood. 2008 Feb 15;111(4):2427-35. Epub 2007 Nov 27.


To test this hypothesis, we generated chimeric mice by transplantation of clonal populations of cells derived from single enhanced green fluorescent protein (EGFP)-marked Lin (-) Sca-1 (+) c-kit (+) CD34 (-) cells and examined the histology of liver tissues obtained from the chimeric mice with carbon tetrachloride (CCl (4))-induced injury.
0(0,0,0,0) Details
16689760 Niiya M, Uemura M, Zheng XW, Pollak ES, Dockal M, Scheiflinger F, Wells RG, Zheng XL: Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo. J Thromb Haemost. 2006 May;4(5):1063-70.

METHODS: In this study, we determined the ADAMTS-13 mRNA, protein, and activity in isolated primary HSCs upon activation on a plastic dish and in liver after administration of carbon tetrachloride (CCl (4)) in rats.
37(0,1,1,7) Details