Protein Information

Name adiponectin
Synonyms 30 kDa adipocyte complemen related protein; 30 kDa adipocyte complement related protein; ACDC; ACRP30; ADIPOQ; APM 1; APM1; Adipocyte C1Q and collagen domain containing…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
14724832 Kamada Y, Tamura S, Kiso S, Matsumoto H, Saji Y, Yoshida Y, Fukui K, Maeda N, Nishizawa H, Nagaretani H, Okamoto Y, Kihara S, Miyagawa J, Shinomura Y, Funahashi T, Matsuzawa Y: Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Gastroenterology. 2003 Dec;125(6):1796-807.

METHODS: The role of adiponectin on liver fibrosis induced by the administration of carbon tetrachloride twice a week for 12 weeks was tested by using adiponectin-knockout mice and an adenovirus-mediated adiponectin-expression system.
99(1,1,3,9) Details
15206143 Maeda N, Funahashi T: [Adiponectin knockout mice] . Nippon Rinsho. 2004 Jun;62(6):1067-76.

Carbon-tetrachloride induced severe liver fibrosis in KO with the elevated gene expression of growth factors.
5(0,0,0,5) Details
19958641 Li HS, Feng Q, Hu YY, Chen SD, Peng JH, Li XM, Xu LL: [The role of adiponectin and adiponectin receptor 2 in the pathology of fatty liver]. Zhonghua Gan Zang Bing Za Zhi. 2009 Nov;17(11):826-30.

The other experimental fatty liver model was induced by subcutaneous injection of carbon tetrachloride (CCl4) in combination with high-fat and low-protein diet for four weeks, and the rats were also divided into normal, model and QHD group, the QHD group was administrated with QHD during the last two weeks.
2(0,0,0,2) Details
19583937 Li HS, Feng Q, Xu LL, Chen SD, Li XM, Hu YY: [Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponection-free fatty acid pathway]. Zhong Xi Yi Jie He Xue Bao. 2009 Jun;7(6):546-51.

METHODS: Forty Wistar male rats were used to establish the NAFLD model by subcutaneous injection of carbon tetrachloride (CCl (4)) for 4 weeks (twice weekly) along with high-fat and low-protein diet for 2 weeks.
After 2-week treatment, the following indexes were detected: (1) liver pathology; (2) contents of serum adiponectin (ADP) and liver triglyceride (TG); (3) concentrations of liver FFA, adiponectin receptor 2 (AdipoR2), malonyl-coenzyme A (malony1-CoA), AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACCase), fatty acid synthase (FAS) and carnitine palmitoyl transferase-1 (CPT-1).
1(0,0,0,1) Details