| Name | IL 10 |
|---|---|
| Synonyms | B TCGF; B cell derived T cell growth factor; CSIF; Cytokine synthesis inhibitory factor; IL 10; IL10; IL10A; Interleukin 10… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17038628 | Horani A, Muhanna N, Pappo O, Melhem A, Alvarez CE, Doron S, Wehbi W, Dimitrios K, Friedman SL, Safadi R: Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G628-38. Epub 2006 Oct 12. Serum interleukin (IL)-10 levels markedly rose, whereas IL-4 fell. Hepatic fibrosis was induced in C57BL/6 mice by intraperitoneal administration of carbon tetrachloride (CCl (4)) for 6 wk. |
2(0,0,0,2) | Details |
| 19787836 | Peng XD, Dai LL, Huang CQ, He CM, Chen LJ: Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. World J Gastroenterol. 2009 Oct 7;15(37):4720-5. Except for the normal control group, all rats in the other groups were administered with carbon tetrachloride to induce hepatic fibrosis. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), transforming growth factor (TGF)-beta1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-10 were measured. |
2(0,0,0,2) | Details |
| 19526130 | Zabrodskii PF, Kirichuk VF, Lim VG, Balashov SV, Svistunov AA: Changes in the cytokine profile and reduced function of lymphocyte subpopulations in subacute tetrachloromethane poisoning. Bull Exp Biol Med. 2009 Jan;147(1):52-4. Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-gamma, IL-2, IL-4, IL-6, IL-10), reduced the IFN-gamma/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which attests to greater damage to Th1 compared to Th2 lymphocytes. |
1(0,0,0,1) | Details |
| 18007553 | Alvarez GC, Madrid-Marina V, Jimenez-Mendez R, Buitimea AL, Roman MB, Cortez-Gomez R, Esparza JR, Rodriguez-Fragoso L: Combined therapy with danazol, pegilated interferon, and ribavirin improves thrombocytopenia and liver injury in rats with fibrosis. Ann Hepatol. 2007 Oct-Dec;6(4):233-41. The only treatment that increased interleukin 10 (IL-10) mRNA in fibrotic rats was PEG-IFN + ribavirin. |
2(0,0,0,2) | Details |
| 17374462 | Zuinen R, Yamaji K, Aoki M, Chikuma T, Hojo H: Early induced, high-level interleukin-6 expression in the rat peritoneal cavity into which a hepatotoxicant carbon tetrachloride was administered. Toxicol Lett. 2007 Apr 5;170(1):42-8. Epub 2007 Feb 20. IL-10 level transiently peaked at 4h and then decreased, but later further increased, reaching the second peak at 24h. |
1(0,0,0,1) | Details |
| 19177741 | Ibrahim ZS, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, Elkattawy AM, Sakamoto KQ, Fujita S: Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Jpn J Vet Res. 2008 Nov;56(3):119-28. Moreover, CCl4 increased iNOS and TNFalpha mRNA, while N. sativa oil administration for one week prior to CCl4 injection downregulated the CCl4-induced iNOS mRNA and up-regulated IL-10 mRNA. |
1(0,0,0,1) | Details |
| 20128048 | Wu SJ, Tam KW, Tsai YH, Chang CC, Chao JC: and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Am J Chin Med. 2010;38(1):99-111. Carbon tetrachloride (40% in olive oil) at a dose of 0.75 ml/kg was injected intraperitoneally once a week. Hepatic proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 were significantly inhibited, and anti-inflammatory cytokine interleukin-10 was significantly increased by supplementation with and/or saikosaponin A. |
1(0,0,0,1) | Details |
| 16539848 | Chou WY, Lu CN, Lee TH, Wu CL, Hung KS, Concejero AM, Jawan B, Wang CH: Electroporative interleukin-10 gene transfer ameliorates carbon tetrachloride-induced murine liver fibrosis by MMP and TIMP modulation. Acta Pharmacol Sin. 2006 Apr;27(4):469-76. |
91(1,1,1,11) | Details |
| 20038333 | Lan L, Chen YW, Sun C, Liu BW, Sun QL, Li DG: [Effect of interleukin 10 gene-modified bone marrow-derived liver stem cells transplantation on hepatic inflammatory response and liver regeneration in hepatic fibrosis rats]. Zhonghua Gan Zang Bing Za Zhi. 2009 Dec;17(12):915-20. METHODS: 50 female Wistar rats were randomly divided into 4 groups: (1) control group: 10 rats were subcutaneously injected with olive oil for 8 weeks; (2) fibrosis groups: 16 rats were subcutaneously injected with carbon tetrachloride (CCl4) for 8 weeks to induce liver fibrosis; (3) BDLSC group: 12 rats were subcutaneously injected with CCl4 for 8 weeks, and were transplanted with 2 x 10 (5) BDLSC at week 4; (4) BDLSC/IL-10 group: 12 rats were subcutaneously injected with CCl4 for 8 weeks, and were transplanted with 2 x 10 (5) IL-10 gene-modified BDLSC at week 4. |
38(0,1,1,8) | Details |
| 15362042 | Safadi R, Ohta M, Alvarez CE, Fiel MI, Bansal M, Mehal WZ, Friedman SL: Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology. 2004 Sep;127(3):870-82. METHODS: We generated transgenic (TG) mice with hepatocyte expression of rat IL-10 (rIL-10) to assess its impact on lymphocyte subsets and activation of hepatic stellate cells following liver injury from carbon tetrachloride (CCl 4 ) or thioacetamide (TAA). |
33(0,1,1,3) | Details |
| 18251166 | Zhang LJ, Zheng WD, Chen YX, Huang YH, Chen ZX, Zhang SJ, Shi MN, Wang XZ: Antifibrotic effects of interleukin-10 on experimental hepatic fibrosis. . Hepatogastroenterology. 2007 Oct-Nov;54(79):2092-8. METHODOLOGY: Rat hepatic fibrosis model induced by carbon tetrachloride was established. |
9(0,0,0,9) | Details |
| 16609999 | Zhang LJ, Zheng WD, Shi MN, Wang XZ: Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver. World J Gastroenterol. 2006 Mar 28;12(12):1918-23. Fibrotic group was injected intraperitoneally with 50% carbon tetrachloride (CCl (4)) (2 mL/kg), twice a week. |
8(0,0,0,8) | Details |
| 17105443 | Zhang L, Wang X, Zheng W, Shi M: The effects of interleukin-10 on the expression of Fas and FasL in rat hepatic stellate cells. Med Chem. 2006 Nov;2(6):611-6. |
8(0,0,0,8) | Details |
| 16688825 | Shi MN, Huang YH, Zheng WD, Zhang LJ, Chen ZX, Wang XZ: Relationship between transforming growth factor beta1 and anti-fibrotic effect of interleukin-10. World J Gastroenterol. 2006 Apr 21;12(15):2357-62. METHODS: Hepatic fibrosis was induced by carbon tetrachloride administered (CCl (4)) intraperitoneally. |
7(0,0,0,7) | Details |
| 16552806 | Huang YH, Shi MN, Zheng WD, Zhang LJ, Chen ZX, Wang XZ: Therapeutic effect of interleukin-10 on CCl4-induced hepatic fibrosis in rats. World J Gastroenterol. 2006 Mar 7;12(9):1386-91. |
5(0,0,0,5) | Details |
| 16097045 | Shi MN, Zheng WD, Zhang LJ, Chen ZX, Wang XZ: Effect of IL-10 on the expression of HSC growth factors in hepatic fibrosis rat. World J Gastroenterol. 2005 Aug 21;11(31):4788-93. |
5(0,0,0,5) | Details |
| 15793858 | Zheng WD, Zhang LJ, Shi MN, Chen ZX, Chen YX, Huang YH, Wang XZ: Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10. World J Gastroenterol. 2005 Mar 28;11(12):1753-8. |
4(0,0,0,4) | Details |
| 19632202 | Peng XD, Dai LL, Huang CQ, He CM, Yang B, Chen LJ: Relationship between anti-fibrotic effect of Panax notoginseng saponins and serum cytokines in rat hepatic fibrosis. Biochem Biophys Res Commun. 2009 Oct 9;388(1):31-4. Epub 2009 Jul 24. Hepatic fibrosis induced by carbon tetrachloride (CCl (4)) was studied in animal models using SD rats. Liver index, serum amino transferase (ALT), amino transferase (AST), transforming growth factor-beta1 (TGF-beta1), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured, respectively. |
2(0,0,0,2) | Details |