Protein Information

Name CK19
Synonyms CK 19; CK19; Cytokeratin 19; K19; K1CS; KRT19; Keratin 19; Keratin type I 40KD…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
17661067 Chiu CC, Huang GT, Chou SH, Chien CT, Chiou LL, Chang MH, Lee HS, Chen DS: Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury. Histochem Cell Biol. 2007 Sep;128(3):217-26. Epub 2007 Jul 28.

Partial hepatectomy or carbon tetrachloride (CCl4) injury, following treatment of rats with 2-acetylaminofluorene (2-AAF) to inhibit proliferation of hepatocytes, induces proliferation of oval cells and possibly their differentiation into nodular foci of hepatocytes when higher doses of 2-AAF are used.
6(0,0,0,6) Details
16770575 Dudas J, Elmaouhoub A, Mansuroglu T, Batusic D, Tron K, Saile B, Papoutsi M, Pieler T, Wilting J, Ramadori G: Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells". Histochem Cell Biol. 2006 Nov;126(5):549-62. Epub 2006 Jun 13.


At embryonal stage of rat liver development (embryonal days (ED) 14-16) hepatoblasts were found to be Prox1 (+)/Cytokeratin (CK) 19 (+) and alpha-fetoprotein (AFP)(+), at this stage Prox1 (-)/CK19 (+)/AFP (-) small cells (early cholangiocytes?) were identified.
4(0,0,0,4) Details
17577995 Zhao WL, Chen YK, Zhang R, Wang YM: [Human umbilical cord blood-derived mononuclear cells repopulate injured mouse liver]. Sheng Wu Gong Cheng Xue Bao. 2007 May;23(3):467-70.

METHODS: Fifteen acute liver injury mouse models were induced by carbon tetrachloride intraperitoneal injection followed by two-thirds hepatectomy and all mice were divided into three groups: cell transplantation group (n = 7), negative control group (n = 3) and blank control group (n = 5).
Human albumin (ALB) and cytokeratin 19 (CK19) were also detected in the mouse sera and liver tissues.
2(0,0,0,2) Details
16781709 Corcelle V, Stieger B, Gjinovci A, Wollheim CB, Gauthier BR: Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins. Exp Cell Res. 2006 Sep 10;312(15):2826-36. Epub 2006 May 19.


Immunohistochemistry was performed using anti-c-kit, OV6, Thy1, CK19, AFP, vWF and Rab3b.
2(0,0,0,2) Details
19756695 Chiu CC, Sheu JC, Chen CH, Lee CZ, Chiou LL, Chou SH, Huang GT, Lee HS: Global gene expression profiling reveals a key role of CD44 in hepatic oval-cell reaction after 2-AAF/CCl4 injury in rodents. Histochem Cell Biol. 2009 Nov;132(5):479-89.

In this study, we treated rats with 2-acetylaminofluorene/carbon tetrachloride to induce hepatic oval cells.
Staining of cytokeratin (CK)-19, an oval-cell marker, was similar between oval cells located next to periportal areas and those located far within the parenchyma.
1(0,0,0,1) Details
19218347 Lee SP, Savard CE, Kuver R: Gallbladder epithelial cells that engraft in mouse liver can differentiate into hepatocyte-like cells. Am J Pathol. 2009 Mar;174(3):842-53. Epub 2009 Feb 13.

Recipient mice with severe-combined immunodeficiency underwent retrorsine treatment and either partial hepatectomy before transplantation or carbon tetrachloride treatment following transplantation.
Most GFP (+) cells surrounded vesicles, were epithelial cell-like in morphology, and expressed the biliary epithelial markers cytokeratin 19 and carbonic anhydrase IV.
1(0,0,0,1) Details