| Name | C met |
|---|---|
| Synonyms | HGF receptor; HGF/SF receptor; HGFR; Hepatocyte growth factor receptor; Hepatocyte growth factor receptor precursor; MET; MET protein; Met proto oncogene tyrosine kinase… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15070743 | Huh CG, Factor VM, Sanchez A, Uchida K, Conner EA, Thorgeirsson SS: Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4477-82. |
6(0,0,0,6) | Details |
| 15287857 | Cramer T, Schuppan D, Bauer M, Pfander D, Neuhaus P, Herbst H: Hepatocyte growth factor and c-Met expression in rat and human liver fibrosis. Liver Int. 2004 Aug;24(4):335-44. |
3(0,0,0,3) | Details |
| 17069928 | Qiu J, Liu Z, Da L, Li Y, Xuan H, Lin Q, Li F, Wang Y, Li Z, Zhao M: Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4. J Hepatol. 2007 Feb;46(2):266-75. Epub 2006 Oct 2. Increased expression of TM4SF4 affected the expression levels of growth factors and receptors, such as TNF-alpha, TNFR1 and c-met. |
2(0,0,0,2) | Details |
| 17009398 | Salazar-Montes A, Ruiz-Corro L, Sandoval-Rodriguez A, Lopez-Reyes A, Armendariz-Borunda J: Increased DNA binding activity of NF-kappaB, STAT-3, SMAD3 and AP-1 in acutely damaged liver. World J Gastroenterol. 2006 Oct 7;12(37):5995-6001. METHODS: USING gel-shift assay and RT-PCR, transcription factors, such as NF-kappaB, STAT-3, SMAD3 and AP-1, and gene expression of inducible synthase (iNOS), hepatocyte growth factor (HGF) and c-met were analyzed in an animal model of chemically induced hepatectomy. |
2(0,0,0,2) | Details |
| 17976157 | Hagiwara S, Otsuka T, Yamazaki Y, Kosone T, Sohara N, Ichikawa T, Sato K, Kakizaki S, Takagi H, Mori M: Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury. Liver Int. 2008 Jan;28(1):126-31. Epub 2007 Nov 1. The protein levels of alpha-smooth muscle actin (alpha-SMA), c-Met and its phosphorylation were determined by Western blot analysis. |
2(0,0,0,2) | Details |
| 18652820 | Salazar-Montes A, Ruiz-Corro L, Lopez-Reyes A, Castrejon-Gomez E, Armendariz-Borunda J: Potent antioxidant role of pirfenidone in experimental cirrhosis. . Eur J Pharmacol. 2008 Oct 24;595(1-3):69-77. Epub 2008 Jul 9. Cirrhosis was induced in rats by ligation of the common bile duct or carbon tetrachloride (CCl (4)) chronic intoxication and treated with pirfenidone or diphenyleneiodonium (a potent known antioxidant) for the last two weeks for bile duct ligation model or for the last three weeks for CCl (4) chronic intoxication. With respect to gene expression, fibrotic genes like transforming growth factor-beta (TGF-beta) and collagen Ialpha (Col-1alpha) were down-regulated by pirfenidone and increased expression of regenerative genes like hepatocyte growth factor (HGF) and c-met . |
1(0,0,0,1) | Details |
| 16818635 | Farazi PA, Zeisberg M, Glickman J, Zhang Y, Kalluri R, DePinho RA: Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res. 2006 Jul 1;66(13):6622-7. These murine CCAs bear histologic and genetic features of human intrahepatic CCA, including dense peritumoral fibrosis, increased inducible synthase, nitrotyrosine, and cyclooxygenase-2 expression, c-Met activation, cErbB2 overexpression, down-regulation of membrane-associated E-cadherin, and p53 codon 248 mutation. |
1(0,0,0,1) | Details |
| 19638569 | Mendieta-Condado E, Pichardo-Olvera M, Sanchez-Sevilla L, Chagoya de Sanchez V, Hernandez-Munoz R: administration accelerates progression of the cell cycle during rat liver regeneration induced by one-third hepatectomy. J Pharmacol Exp Ther. 2009 Oct;331(1):122-32. Epub 2009 Jul 28. We have shown that administration is capable of reversing fibrosis in the carbon tetrachloride-induced rat cirrhotic liver, stimulating the diminished proliferative potential of the cirrhotic liver. These effects were also accompanied for a long-lasting increase of serum and liver levels of HGF and liver expression of c-Met and HGF liver activator. |
1(0,0,0,1) | Details |