| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17590492 | Lee KJ, Choi JH, Jeong HG: Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2007 Nov;45(11):2118-25. Epub 2007 May 24. Treatment of the mice with kahweol and cafestol also resulted in a significant decrease in the cytochrome P450 2E1 (CYP2E1), the major isozyme involved in CCl (4) bioactivation, specific enzyme activities, such as and hydroxylation. |
2(0,0,0,2) | Details |
| 14706259 | Yokogawa K, Watanabe M, Takeshita H, Nomura M, Mano Y, Miyamoto K: Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride. Int J Pharm. 2004 Jan 28;269(2):479-89. Good correlations were observed between mRNA expression and enzyme activity of CYP2C11, CYP2E1, CYP3A2 and CYP1A2 in livers of rats given various doses of CCl (4). |
2(0,0,0,2) | Details |
| 16298865 | Jin YS, Heo SI, Lee MJ, Rhee HI, Wang MH: Free radical scavenging and hepatoprotective actions of Quercus aliena acorn extract against CCl4-induced liver. Free Radic Res. 2005 Dec;39(12):1351-8. Expression of cytochrome P450 2E1 (CYP2E1) mRNA, as measured by RT-PCR, was significantly decreased in the livers of Quercus aliena acorn-pretreated rats compared with the livers of the control group. |
2(0,0,0,2) | Details |
| 14969415 | Jeon TI, Hwang SG, Lim BO, Park DK: Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats. Biotechnol Lett. 2003 Dec;25(24):2093-6. Expression of cytochromeP450 2E1 (CYP2E1) protein was significantly decreased to 88% in CCl4-treated rats but remained at control levels when EPB was also administered. |
2(0,0,0,2) | Details |
| 19595748 | Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH: Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett. 2009 Oct 28;190(2):150-5. Epub 2009 Jul 10. The results of immunoblot analyses showed that 10 and 25mg/kg dicofol increased protein levels of CYP1A1, CYP2B, CYP2E1, and 3A in liver. |
2(0,0,0,2) | Details |
| 19836219 | Quan J, Yin X, Xu H: Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat. Exp Toxicol Pathol. 2009 Oct 14. Furthermore, serum tumor necrosis factor-alpha (TNF-alpha), hepatic level, inducible synthase (iNOS) and cyclooxygenase-2 (COX-2) protein contents were elevated while cytochrome P450 2E1 (CYP2E1) expression and function were inhibited. |
2(0,0,0,2) | Details |
| 18436364 | Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG: Protective effect of phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2008 Jun 3;248(1):18-24. Epub 2008 Mar 20. Moreover, the effect of CAPE on CYP2E1, the major isozyme involved in CCl (4) bioactivation, was investigated. |
2(0,0,0,2) | Details |
| 18291569 | Lee KJ, Choi JH, Kim HG, Han EH, Hwang YP, Lee YC, Chung YC, Jeong HG: Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice. Food Chem Toxicol. 2008 May;46(5):1778-85. Epub 2008 Jan 18. The effect of CKS on CYP2E1, the major isozyme involved in CCl (4) bioactivation, was investigated. |
2(0,0,0,2) | Details |
| 18460814 | Baek SH, Park M, Suh JH, Choi HS: Protective effects of an extract of young radish (Raphanus sativus L) cultivated with -radish extract) and of on carbon tetrachloride-induced hepatotoxicity. Biosci Biotechnol Biochem. 2008 May;72(5):1176-82. Epub 2008 May 7. Oral administration of the -radish extract and of after CCl (4)-induced liver injury both decreased the serum level of ALT, reduced the necrotic zones, inhibited lipid peroxidation, and induced phase 2 enzymes without affecting cytochrome P450-2E1 (CYP2E1). |
1(0,0,0,1) | Details |
| 15619574 | Ha KT, Yoon SJ, Choi DY, Kim DW, Kim JK, Kim CH: Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. J Ethnopharmacol. 2005 Jan 15;96(3):529-35. Epub 2004 Dec 8. The expression level of cytochrome P450 2E1 (CYP2E1) mRNA and protein, as measured by reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot analysis, was significantly decreased in the liver of LFE-pretreated rats when compared with that in the liver of control group. |
2(0,0,0,2) | Details |
| 20007753 | Yang P, Han Z, Chen P, Zhu L, Wang S, Hua Z, Zhang J: A contradictory role of A1 receptor in carbon tetrachloride- and bile duct ligation-induced liver fibrosis in mice. J Pharmacol Exp Ther. 2010 Mar;332(3):747-54. Epub 2009 Dec 10. Hepatocyte damage was reduced in A (1) AR (-/-) mice after a single injection of CCl (4), with down-regulation of CYP2E1 and UCP2 gene expression in livers, which resulted in impaired liver sensitivity to CCl (4). |
1(0,0,0,1) | Details |
| 19913046 | Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY: Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):318-25. Epub 2009 Nov 11. Ginsan inhibited CCl (4) induced lipid peroxidation through the cytochrome P450 2E1 (CYP2E1) downregulation. |
1(0,0,0,1) | Details |
| 17610925 | Kim YC, Yim HK, Jung YS, Park JH, Kim SY: Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone. Toxicol Appl Pharmacol. 2007 Aug 15;223(1):56-65. Epub 2007 May 24. Carbon tetrachloride treatment 24 h prior to a challenging dose of carbon tetrachloride or decreased the resulting hepatotoxicity both in male and female mice as determined by histopathological examination and increases in serum enzyme activities. Increases in Cyp2e1 and Cyp2b expression were also evident in male kidney. |
1(0,0,0,1) | Details |
| 16445600 | Yim HK, Jung YS, Kim SY, Kim YC: Contrasting changes in phase I and phase II metabolism of in male mice pretreated with carbon tetrachloride. Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):225-30. CYP2E1 and 1A2 expressions were decreased significantly by CCl (4). |
1(0,0,0,1) | Details |
| 17177172 | Kim SJ, Jung YS, Yoon MY, Kim YC: Comparative effects of dimethylsulfoxide on metabolism and toxicity of carbon tetrachloride and dichloromethane. J Appl Toxicol. 2007 Jan-Feb;27(1):25-31. DMSO induces the hepatic metabolizing activity mediated by CYP2E1, but the presence of this solvent in the enzyme site may inhibit directly the enzymatic interaction with a substrate. |
1(0,0,0,1) | Details |
| 16273607 | Yamazaki Y, Kakizaki S, Horiguchi N, Takagi H, Mori M, Negishi M: Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity. World J Gastroenterol. 2005 Oct 14;11(38):5966-72. Although the main pathway of CCl (4)-induced acute liver injury is mediated by CYP2E1, CAR modulates its pathway via induction of CYP2B10 and 3A11 in the presence of activator or inhibitor. |
1(0,0,0,1) | Details |
| 19812219 | Hosono-Fukao T, Hosono T, Seki T, Ariga T: Diallyl trisulfide protects rats from carbon tetrachloride-induced liver injury. J Nutr. 2009 Dec;139(12):2252-6. Epub 2009 Oct 7. Western blot and spectrophotometric analyses indicated that DATS suppressed cytochrome P450 2E1 activity and its protein level and elevated those of glutathione S-transferase. |
1(0,0,0,1) | Details |
| 19927273 | Ana T, Biljana B, Isidora S, Marina M, Neda MD, Silvana P: Effects of Athamanta turbith fruit essential oils on CCl (4)-induced hepatic failure in mice and their antioxidant properties. Phytother Res. 2009 Nov 19. The effects of essential oils isolated from mature fruits of Athamanta turbith ssp. hungarica (Borbas) Tutin and A. turbith ssp. haynaldii (Borbas & Uechtr.) Tutin (Umbelliferae) on some liver biochemical parameters in mice intoxicated with carbon tetrachloride were investigated. Therefore, their influence on biochemical parameters in intoxicated animals might be linked to the inhibition of enzymes (cytochrome P450 2E1) involved in metabolic activation of halomethanes. |
1(0,0,0,1) | Details |
| 19393728 | Zhang F, Shu R, Wu X, Zhao X, Feng D, Wang L, Lu S, Liu Q, Xiang Y, Fei J, Huang L, Wang Z: Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in BPOZ2-deficient mice. Toxicol Lett. 2009 Aug 10;188(3):201-7. Epub 2009 Apr 23. After acute CCl (4) administration, BPOZ2 null mice exhibited delayed liver injury and impaired hepatocyte proliferation, which was accompanied by altered kinetics of CYP2E1 protein expression, compromised cyclin D1 expression and shortened duration of ERK activation. |
1(0,0,0,1) | Details |
| 17940038 | Doty SL, James CA, Moore AL, Vajzovic A, Singleton GL, Ma C, Khan Z, Xin G, Kang JW, Park JY, Meilan R, Strauss SH, Wilkerson J, Farin F, Strand SE: Enhanced phytoremediation of volatile environmental pollutants with transgenic trees. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16816-21. Epub 2007 Oct 16. Small, volatile hydrocarbons, including trichloroethylene, vinyl carbon tetrachloride, and chloroform, are common environmental pollutants that pose serious health effects. We have developed transgenic poplar (Populus tremula x Populus alba) plants with greatly increased rates of metabolism and removal of these pollutants through the overexpression of cytochrome P450 2E1, a key enzyme in the metabolism of a variety of halogenated compounds. |
1(0,0,0,1) | Details |
| 15772367 | Farkas D, Tannenbaum SR: Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes. Toxicol Sci. 2005 Jun;85(2):927-34. Epub 2005 Mar 16. However, no significant toxicity could be measured following exposures to 5 mM carbon tetrachloride, 1 mM N, N-dimethylformamide (DMF), 1 mM vinyl and 1 mM Western blots of cell lysates showed that hepatocytes maintained CYP1A, 2B, 3A2 but gradually lost CYP2E1, which is the main metabolic enzyme for acetaminophen, carbon tetrachloride, and DMF. |
1(0,0,0,1) | Details |
| 19177741 | Ibrahim ZS, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, Elkattawy AM, Sakamoto KQ, Fujita S: Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Jpn J Vet Res. 2008 Nov;56(3):119-28. Intraperitoneal injection of rats with CCl4 drastically decreased CYP2E1, CYP2B, CYP3A2, CYP2C11, and CYP1A2 mRNA and protein expressions. |
1(0,0,0,1) | Details |
| 17084954 | Lima CF, Fernandes-Ferreira M, Pereira-Wilson C: Drinking of Salvia officinalis tea increases CCl (4)-induced hepatotoxicity in mice. Food Chem Toxicol. 2007 Mar;45(3):456-64. Epub 2006 Oct 1. Taking in consideration these effects, in the present study the potential protective effects of sage tea drinking against a situation of hepatotoxicity due to free radical formation, such as that caused by carbon tetrachloride (CCl (4)), were evaluated in mice of both genders. Since CCl (4) toxicity results from its bioactivation mainly by cytochrome P450 (CYP) 2E1, the expression level of this protein was measured by Western Blot. |
1(0,0,0,1) | Details |
| 16142352 | Iizasa T, Baba M, Saitoh Y, Suzuki M, Haga Y, Iyoda A, Chang H, Hiroshima K, Itoga S, Tomonaga T, Nomura F, Fujisawa T: A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population. Oncol Rep. 2005 Oct;14(4):919-23. Cytochrome P450 2E1 (CYP2E1) catalyzes the metabolic activation of the procarcinogen, N-nitrosodimethylamine, and cytotoxic carbon tetrachloride compounds. |
85(1,1,1,5) | Details |
| 19336974 | Mochizuki M, Shimizu S, Urasoko Y, Umeshita K, Kamata T, Kitazawa T, Nakamura D, Nishihata Y, Ohishi T, Edamoto H: Carbon tetrachloride-induced hepatotoxicity in pregnant and lactating rats. J Toxicol Sci. 2009 Apr;34(2):175-81. Carbon tetrachloride (CCl4) is well known to induce hepatotoxicity after being metabolized to trichloromethyl free radical ((.) CCl3) by CYP2E1. |
85(1,1,1,5) | Details |
| 19827746 | El BK, Hashimoto Y, Muzandu K, Ikenaka Y, Ibrahim ZS, Kazusaka A, Fujita S, Ishizuka M: Protective effect of Pleurotus cornucopiae mushroom extract on carbon tetrachloride-induced hepatotoxicity. Jpn J Vet Res. 2009 Aug;57(2):109-18. The present study investigated the protective effects of an aqueous extract of PC on carbon tetrachloride (CCl4)-induced hepatotoxicity and the possible mechanism involved in this protection including cytochrome P450 (CYP) 2E1. |
82(1,1,1,2) | Details |
| 15178132 | Murali B, Korrapati MC, Warbritton A, Latendresse JR, Mehendale HM: Tolerance of aged Fischer 344 rats against chlordecone-amplified carbon tetrachloride toxicity. Mech Ageing Dev. 2004 Jun;125(6):421-35. Hepatomicrosomal CYP2E1 protein, enzyme activity, and covalent binding of 14CCl4-derived radiolabel were measured in normal and CD fed rats. |
1(0,0,0,1) | Details |
| 17256749 | Donthamsetty S, Bhave VS, Mitra MS, Latendresse JR, Mehendale HM: Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity. Hepatology. 2007 Feb;45(2):391-403. |
0(0,0,0,0) | Details |
| 15095147 | Park EJ, Zhao YZ, Kim YH, Lee JJ, Sohn DH: Acanthoic acid from Acanthopanax koreanum protects against liver injury induced by tert-butyl hydroperoxide or carbon tetrachloride in vitro and in vivo. Planta Med. 2004 Apr;70(4):321-7. |
0(0,0,0,0) | Details |
| 16434548 | Joshi M, Tyndale RF: Induction and recovery time course of rat brain CYP2E1 after treatment. Drug Metab Dispos. 2006 Apr;34(4):647-52. Epub 2006 Jan 24. CYP2E1, the primary -metabolizing cytochrome P450, metabolizes endogenous substrates (e.g., and drugs (e.g., chlorzoxazone) and bioactivates procarcinogens (e.g., tobacco-specific nitrosamines) and toxins (e.g., carbon tetrachloride). |
37(0,1,1,7) | Details |
| 15962327 | Taieb D, Malicet C, Garcia S, Rocchi P, Arnaud C, Dagorn JC, Iovanna JL, Vasseur S: Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity. Hepatology. 2005 Jul;42(1):176-82. |
35(0,1,1,5) | Details |
| 17710613 | Yoon M, Madden MC, Barton HA: Extrahepatic metabolism by CYP2E1 in PBPK modeling of lipophilic volatile organic chemicals: impacts on metabolic parameter estimation and prediction of dose metrics. J Toxicol Environ Health A. 2007 Sep;70(18):1527-41. The impact of accounting for extrahepatic metabolism by CYP2E1 on the estimation of metabolic parameters and the prediction of dose metrics was evaluated for three lipophilic VOCs: vinyl trichloroethylene, and carbon tetrachloride. |
35(0,1,1,5) | Details |
| 18350910 | James CA, Xin G, Doty SL, Strand SE: Degradation of low molecular weight volatile organic compounds by plants genetically modified with mammalian cytochrome P450 2E1. Environ Sci Technol. 2008 Jan 1;42(1):289-93. Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the mammalian metabolism of several low molecular weight volatile organic compounds (VOCs), such as trichloroethylene (TCE), vinyl (VC), carbon tetrachloride (CT), chloroform, and bromodichloromethane (BDCM), which are all common environmental pollutants that pose risks to human health. |
33(0,1,1,3) | Details |
| 17763046 | Manibusan MK, Odin M, Eastmond DA: Postulated carbon tetrachloride mode of action: a review. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007 Jul-Sep;25(3):185-209. Mechanistic studies provide evidence that metabolism of carbon tetrachloride via CYP2E1 to highly reactive free radical metabolites plays a critical role in the postulated mode of action. |
31(0,1,1,1) | Details |
| 16162422 | Qin LQ, Wang PY, Wang Y, Kaneko T, Hoshi K, Sato A: Voglibose potentiates the hepatotoxicity of carbon tetrachloride and by inducing CYP2E1 in rats. Hepatol Res. 2005 Sep;33(1):50-6. Epub 2005 Sep 12. |
8(0,0,1,3) | Details |
| 17660703 | Qin LQ, Wang Y, Xu JY, Kaneko T, Sato A, Wang PY: One-day dietary restriction changes hepatic metabolism and potentiates the hepatotoxicity of carbon tetrachloride and chloroform in rats. Tohoku J Exp Med. 2007 Aug;212(4):379-87. In the present study, we fed male Wistar rats at five levels of food intake for one day, including conventional feeding (60 kcal), three of DR (45, 30, and 15 kcal), and fasting (0 kcal), and observed the metabolic changes of hepatic cytochrome P450 2E1 (CYP2E1) and the hepatotoxicity of chloroform (CHCl (3)) and carbon tetrachloride (CCl (4)). |
8(0,0,1,3) | Details |
| 15763544 | Caro AA, Cederbaum AI: Inhibition of CYP2E1 catalytic activity in vitro by Biochem Pharmacol. 2005 Apr 1;69(7):1081-93. Since the K (i) for SAM inhibition of CYP2E1 activity is relatively high, inhibition of CYP2E1 activity is not likely to play a major role in the ability of SAM to protect against the hepatotoxicity produced by toxins requiring metabolic activation by CYP2E1 such as carbon tetrachloride, thioacetamide and carcinogens. |
6(0,0,0,6) | Details |
| 17084009 | Avasarala S, Yang L, Sun Y, Leung AW, Chan WY, Cheung WT, Lee SS: A temporal study on the histopathological, biochemical and molecular responses of CCl (4)-induced hepatotoxicity in Cyp2e1-null mice. Toxicology. 2006 Dec 7;228(2-3):310-22. Epub 2006 Oct 6. |
5(0,0,0,5) | Details |
| 19848203 | Hong ZF, Li TJ, Zhao JY: [Effect of total alkaloids of Rubus alceaefolius poiron on gene expressions of CYP2E1 and CYP3A1 in rats with acute liver injury]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Aug;29(8):711-5. The model of acute hepatic injury was established with intra-peritoneal injection of carbon tetrachloride. |
5(0,0,0,5) | Details |
| 17533807 | Diaz Gomez MI, Fanelli SL, Delgado de Layno AM, Castro JA, Castro GD: Liver nuclear and microsomal CYP2E1-mediated metabolism of xenobiotics in rats chronically drinking an -containing liquid diet. Toxicol Ind Health. 2006 Oct;22(9):367-74. In previous studies from our laboratory, the presence in highly purified liver nuclei of metabolic pathways for processing (EtOH), N-nitrosodimethylamine (NDMA), carbon tetrachloride and chloroform was reported. |
4(0,0,0,4) | Details |
| 15797236 | Lewis MD, Roberts BJ: Role of CYP2E1 activity in endoplasmic reticulum ubiquitination, proteasome association, and the unfolded protein response. Arch Biochem Biophys. 2005 Apr 15;436(2):237-45. |
4(0,0,0,4) | Details |
| 20155282 | Irie H, Asano-Hoshino A, Sekino Y, Nogami M, Kitagawa T, Kanda H: Striking LD (50) variation associated with fluctuations of CYP2E1-positive cells in hepatic lobule during chronic CCl (4) exposure in mice. Virchows Arch. 2010 Feb 13. Intraperitoneal injection of serially diluted carbon tetrachloride (CCl (4)) from 0.2 to 2.0 ml/kg produced an LD (50) value of 0.46 ml/kg in the normal mouse. |
4(0,0,0,4) | Details |
| 19327382 | Tung YT, Wu JH, Huang CC, Peng HC, Chen YL, Yang SC, Chang ST: Protective effect of Acacia confusa bark extract and its active compound against carbon tetrachloride-induced chronic liver injury in rats. Food Chem Toxicol. 2009 Jun;47(6):1385-92. Epub 2009 Mar 25. CCl (4)-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), peroxidase (GPX) and catalase (CAT) in erythrocytes. |
3(0,0,0,3) | Details |
| 18595136 | Tasduq SA, Kaiser PJ, Gupta BD, Gupta VK, Johri RK: Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against -mediated toxicity induced by carbon tetrachloride. World J Gastroenterol. 2008 Jun 21;14(23):3693-709. METHODS: CCl (4) is a well characterized hepatotoxin, and inducer of cytochrome P450 2E1 (CYP2E1)-mediated oxidative stress. |
3(0,0,0,3) | Details |
| 19793341 | Quan J, Piao L, Wang X, Li T, Yin X: Rossicaside B protects against carbon tetrachloride-induced hepatotoxicity in mice. Basic Clin Pharmacol Toxicol. 2009 Dec;105(6):380-6. Epub 2009 Sep 30. Furthermore, the contents of hepatic inducible synthase (iNOS), cyclooxygenase-2 (COX-2) and haem oxygenase-1 (HO-1) were elevated after CCl (4) treatment while the cytochrome P450 2E1 (CYP2E1)-specific monooxygenase activity was suppressed. |
3(0,0,0,3) | Details |
| 16288784 | Sugiyama T, Nagata J, Yamagishi A, Endoh K, Saito M, Yamada K, Yamada S, Umegaki K: Selective protection of against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats. Life Sci. 2006 Apr 4;78(19):2188-93. Epub 2005 Nov 8. Chronic CCl (4) injection drastically decreased CYP activity, especially CYP2E1 activity, which is involved in the bioactivation of CCl (4), thereby producing reactive free radicals. |
3(0,0,0,3) | Details |
| 19352025 | Quan J, Piao L, Xu H, Li T, Yin X: Protective effect of iridoid glucosides from Boschniakia rossica on acute liver injury induced by carbon tetrachloride in rats. Biosci Biotechnol Biochem. 2009 Apr 23;73(4):849-54. Epub 2009 Apr 7. The liver antioxidative defense system, including superoxide dismutase (SOD), peroxidase (GPx) and glutathione reductase (GR), as well as the cytochrome P450 2E1 (CYP2E1) expression were suppressed, however. |
3(0,0,0,3) | Details |
| 18038910 | Hwang YP, Choi CY, Chung YC, Jeon SS, Jeong HG: Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. Arch Pharm Res. 2007 Oct;30(10):1309-17. The effects of puerarin on cytochrome P450 (CYP) 2E1, the major isozyme involved in CCl4 bioactivation, were also investigated. |
3(0,0,0,3) | Details |