| Name | senescence marker protein 30 |
|---|---|
| Synonyms | RC; RGN; Regucalcin; SMP 30; SMP30; Senescence marker protein 30; regucalcin (senescence marker protein 30); Regucalcins… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20162732 | Park JK, Ki MR, Lee HR, Hong IH, Ji AR, Ishigami A, Park SI, Kim JM, Chung HY, Yoo SE, Jeong KS: Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice. Hepatology. 2009 Dec 9. We demonstrated that carbon tetrachloride (CCl (4))-induced liver fibrosis and the nuclear translocation of p-Smad2/3, the immediate downstream of transforming growth factor beta (TGF-beta), were significantly inhibited in the liver of SMP30 KO mice compared with wildtype (WT) mice. |
87(1,1,1,7) | Details |
| 18308447 | Park JK, Jeong DH, Park HY, Son KH, Shin DH, Do SH, Yang HJ, Yuan DW, Hong IH, Goo MJ, Lee HR, Ki MR, Ishigami A, Jeong KS: Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knock-out mice. Toxicology. 2008 Apr 18;246(2-3):132-42. Epub 2008 Jan 19. This study focused on the hepatoprotective effect of Arazyme on carbon tetrachloride (CCl4)-induced acute hepatic injury in senescence marker protein 30 (SMP30) knock-out (KO) mice and SMP30 wild-type (WT) mice. |
9(0,0,1,4) | Details |
| 15247044 | Feng D, Kondo Y, Ishigami A, Kuramoto M, Machida T, Maruyama N: Senescence marker protein-30 as a novel antiaging molecule. Ann N Y Acad Sci. 2004 Jun;1019:360-4. Because the expression is reduced by carbon tetrachloride, one can speculate that the expression is modulated by oxidative stress increased with aging. |
7(0,0,0,7) | Details |
| 19736546 | Goo MJ, Ki MR, Lee HR, Yang HJ, Yuan DW, Hong IH, Park JK, Hong KS, Han JY, Hwang OK, Kim DH, Do SH, Cohn RD, Jeong KS: Helicobacter pylori promotes hepatic fibrosis in the animal model. Lab Invest. 2009 Nov;89(11):1291-303. Epub 2009 Sep 7. To elucidate the pathological effect of H. pylori infection on the progression of hepatic fibrosis, C57BL/6 mice and Sprague-Dawley rats were orally inoculated with H. pylori, and hepatic fibrosis was induced with carbon tetrachloride (CCl (4)) administration. Compared with the CCl (4)-treated group, alpha-smooth muscle actin and transforming growth factor-beta1 were enhanced; however, senescence marker protein-30, a multifunctional protein protecting hepatocytes against oxidative stress and apoptosis, was suppressed in the CCl (4)+H. pylori group. |
1(0,0,0,1) | Details |