| Name | catalase |
|---|---|
| Synonyms | CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18786523 | Jayakumar T, Sakthivel M, Thomas PA, Geraldine P: Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain. Chem Biol Interact. 2008 Nov 25;176(2-3):108-20. Epub 2008 Aug 22. Quantitative and qualitative analysis of catalase (CAT), superoxide dismutase (SOD), peroxidase (Gpx) and glutathione-S-transferase (GST) revealed lower activities of these antioxidant enzymes in the kidneys, heart and brain of rats exposed to CCl4. |
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| 16117622 | Shahjahan M, Vani G, Devi CS: Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. Phytother Res. 2006 Nov;20(11):935-40. The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity. Antioxidant status was significantly lowered in CCl4-treated animals with a significant (P < .001) increase in the levels of lipid peroxides [thiobarbituric acid-reactive substances (TBARS)], significantly lower levels of (GSH), and lowered activities of superoxide dismutase (SOD), catalase (CAT), and GSH peroxidase (GPx). |
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| 18989868 | Nogueira CW, Borges LP, Souza AC: Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats. J Agric Food Chem. 2009 Sep 23;57(18):8628-34. The liver and kidney were utilized for determination of histopathology, biochemical (ALT) and alanine (AST) aminotransferases, alkaline phosphatase (ALP), total bilirrubin (TB) and gamaglutamyl transferase (GGT)] and toxicological parameters [thiobarbituric reactive species (TBARS) levels, catalase activity, nonprotein thiols (NPSH) and aminolevulinate dehydratase (-ALA-D) activity]. |
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| 18385828 | Ohta Y, Ohashi K, Matsura T, Tokunaga K, Kitagawa A, Yamada K: Octacosanol attenuates disrupted hepatic reactive species metabolism associated with acute liver injury progression in rats intoxicated with carbon tetrachloride. Br J Nutr. 2009 Dec;102(12):1767-75. Epub . In the liver of CCl (4)-intoxicated rats, increases in lipid peroxide (LPO) concentration and myeloperoxidase activity and decreases in superoxixde dismutase activity and (GSH) concentration occurred 6 h after intoxication and these changes were enhanced with an increase in xanthine oxidase activity and a decrease in catalase activity at 24 h. |
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| 17886222 | Ahn TH, Yang YS, Lee JC, Moon CJ, Kim SH, Jun W, Park SC, Kim JC: Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats. Phytother Res. 2007 Nov;21(11):1015-9. In addition, increased malondialdehyde (MDA) concentration, (GSH) content, and decreased catalase, superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities were observed in the hepatic tissues. |
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| 18476390 | Anilakumar KR, Krishna KR, Chandramohan G, Khanum F, Bawa AS: Bees wax polyphenols as suppressor of CC1--induced oxidative stress in rats. Indian J Physiol Pharmacol. 2007 Oct-Dec;51(4):361-7. As the polyphenols are thought to protect cell constituents against oxidative damage through scavenging of free radicals, the present work was undertaken to evaluate the effects of polyphenols extracted from bees wax on the oxidative stress induced by carbon tetrachloride (CCl4) in rats. The results showed a significant decrease in hepatic antioxidant enzyme activities viz. catalase, glucose-6-phosphate dehydrogenase (G-6-PDH), peroxidase (GSH-Px), glutathione reductase, superoxide dismutase (SOD) and a significant increase in glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (GGT) by CCl4, probably due to the peroxidative effects. |
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| 16945181 | Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK: Enhanced therapeutic potential of -phospholipid complex in rats. J Pharm Pharmacol. 2006 Sep;58(9):1227-33. -phospholipid complex was prepared and assessed for antioxidant activity in carbon tetrachloride intoxicated rats at a dose level of 100 mg kg-1 (p.o.). Marker enzymes of liver, namely peroxidase, superoxide dismutase, catalase and thiobarbituric acid reactive substances, were measured to evaluate the antioxidant potential at the same dose level. |
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| 20227265 | Coballase-Urrutia E, Pedraza-Chaverri J, Cardenas-Rodriguez N, Huerta-Gertrudis B, Edna Garcia-Cruz M, Ramirez-Morales A, Javier Sanchez-Gonzalez D, Maria Martinez-Martinez C, Camacho-Carranza R, Javier Espinosa-Aguirre J: Hepatoprotective effect of acetonic and methanolic extracts of Heterotheca inuloides against CCl (4)-induced toxicity in rats. Exp Toxicol Pathol. 2010 Mar 11. A model of hepatotoxicity by carbon tetrachloride (CCl (4)) in rats was used in order to evaluate the protective potential of the acetonic and methanolic extracts of Heterotheca inuloides. Furthermore, the decrease in the activity of several antioxidant enzymes including superoxide dismutase, catalase and peroxidase in CCl (4)-induced liver injury was alleviated by the pretreatment with H. inuloides methanolic extract or |
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| 18481019 | Kang KS, Kim ID, Kwon RH, Lee JY, Kang JS, Ha BJ: The effects of fucoidan extracts on CCl (4)-induced liver injury. Arch Pharm Res. 2008 May;31(5):622-7. Epub 2008 May 15. The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against CCl (4)-induced oxidative stress by monitoring the levels of transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx). |
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| 19652474 | Sugiyama A, Suzuki K, Mitra S, Arashida R, Yoshida E, Nakano R, Yabuta Y, Takeuchi T: Hepatoprotective effects of paramylon, a beta-1, 3-D-glucan isolated from Euglena gracilis Z, on acute liver injury induced by carbon tetrachloride in rats. J Vet Med Sci. 2009 Jul;71(7):885-90. The treatment of paramylon recovered reductions of activity of hepatic superoxide dismutase, catalase and peroxidase induced by CCl (4). |
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| 15267142 | Bhandarkar M, Khan A: Protective effect of Lawsonia alba Lam., against CCl4 induced hepatic damage in albino rats. Indian J Exp Biol. 2003 Jan;41(1):85-7. The oral administration in varying doses of aqueous suspension of extract of L. alba, bark extract to rats for 10 days afforded good hepatoprotection against CCl4 induced elevation in serum marker enzymes, serum liver lipid peroxidation and reduction in total serum protein, liver peroxidase, glutathione-s-transferase, superoxide dismutase and catalase activity. |
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| 19548269 | Ozturk IC, Ozturk F, Gul M, Ates B, Cetin A: Protective effects of on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats. Cell Biochem Funct. 2009 Jul;27(5):309-15. MDA, total (T.GSH) levels and superoxide dismutase (SOD), catalase (CAT), peroxidase (GSH-PX) activities were measured in the liver of all groups of rats and also serum amino transferase (ALT) and amino transferase (AST) activities were detected to determine liver functions in all groups of rats. |
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| 17431769 | Amalia PM, Possa MN, Augusto MC, Francisca LS: prevents oxidative stress in cirrhotic rats. 131. Our aim was to study the protective effect of quercitin on liver cirrhosis induced by carbon tetrachloride (CCl (4)) in rats and its relationship with liver morphology. Blood samples were taken for determination of serum indicators (ALT, AST, total conjugated factor V) and the livers were dissected out and divided into two parts: one was homogenized and the supernatant was used for measurement of superoxide dismutase (SOD), catalase, and peroxidase (GPx) activities, as well as lipid peroxidation. |
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| 19429327 | Shen X, Tang Y, Yang R, Yu L, Fang T, Duan JA: The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacol. 2009 Apr 21;122(3):555-60. Epub 2009 Feb 7. Product of lipid peroxidation (MDA), activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (GSH-Px), and (GSH) contents were evaluated for oxidative stress in hepatic injury. |
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| 18404596 | Leal LK, Fonseca FN, Pereira FA, Canuto KM, Felipe CF, Fontenele JB, Pitombeira MV, Silveira ER, Viana GS: Protective effects of amburoside A, a glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats. Planta Med. 2008 Apr;74(5):497-502. Epub 2008 Apr 10. Furthermore, it restored catalase activity to normal values, which was significantly increased after CCl (4) treatment. The aim of this study was to investigate the possible beneficial effects of amburoside A, AMB [4-(O-beta- D-glycopyranosyl) benzyl protocatechoate], against carbon tetrachloride (CCl (4)) toxicity in rats. |
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| 14969348 | Lee S, Son D, Ryu J, Lee YS, Jung SH, Kang J, Lee SY, Kim HS, Shin KH: Anti-oxidant activities of Acanthopanax senticosus stems and their lignan components. Arch Pharm Res. 2004 Jan;27(1):106-10. The fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and peroxidase by 30.31, 19.82 and 155%, respectively. |
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| 19446540 | Singh BN, Singh BR, Sarma BK, Singh HB: Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. J Ethnopharmacol. 2005 Jan 15;96(3):529-35. Epub 2004 Dec 8. Chemopreventive potential of Acacia nilotica bark extract (ANBE) against single intraperitoneal injection of N-nitrosodiethylamine (NDEA, 200mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (CCl (4), 3 ml/kg) for 6 weeks induced hepatocellular carcinoma (HCC) in rats was studied. Additionally, ANBE also increased the activities of antioxidant enzymes viz., catalase (CAT), superoxide dismutase (SOD), peroxidase (GPx), and glutathione-S-transferase (GST) in the liver of NDEA-administered rats. |
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| 16117609 | Kim NY, Lee MK, Park MJ, Kim SJ, Park HJ, Choi JW, Kim SH, Cho SY, Lee JS: Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83. The CCl4-treated rats had significantly lower activities of glutathione reductase, glutathione S-transferase, superoxide dismutase, catalase, and peroxidase. |
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| 18186586 | Chang HF, Lin YH, Chu CC, Wu SJ, Tsai YH, Chao JC: Protective effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on liver injury in rats. Am J Chin Med. 2007;35(6):995-1009. This study investigated the effects of the combined extracts of Ginkgo biloba, Panax ginseng, and Schizandra chinensis at different doses on hepatic antioxidant status and fibrosis in rats with carbon tetrachloride (CCl4)-induced liver injury. Hepatic catalase activity and the ratio of reduced to were significantly higher (p < 0.05) in the HE group than those in the CCl4 group. |
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| 18783728 | Zeashan H, Amresh G, Singh S, Rao CV: Hepatoprotective activity of Amaranthus spinosus in experimental animals. J Clin Biochem Nutr. 2008 Mar;42(2):118-25. The hepatoprotective and antioxidant activity of 50% ethanolic extract of whole plant of Amaranthus spinosus (ASE) was evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. Meanwhile, in vivo antioxidant activities as malondialdehyde (MDA), hydroperoxides, (GSH), superoxide dismutase (SOD) and catalase (CAT) were also screened which were also found significantly positive in a dose dependent manner. |
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| 17877147 | Kujawska M, Jodynis-Liebert J, Ewertowska M, Adamska T, Matlawska I, Bylka W: Protective effect of Aquilegia vulgaris (L.) on carbon tetrachloride-induced oxidative stress in rats. Indian J Exp Biol. 2007 Aug;45(8):702-11. Activity of antioxidant and related enzymes (catalase and glucose-6-phosphate dehydrogenase) inhibited by CCl4 was significantly restored after administration of the extract. |
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| 19634318 | Lee MK, Kim SH, Yang H, Lim DY, Ryu JH, Lee ES, Jew SS, Park HG, Sung SH, Kim YC: Asiatic acid derivatives protect primary cultures of rat hepatocytes against carbon tetrachloride-induced injury via the cellular antioxidant system. Nat Prod Commun. 2009 Jun;4(6):765-8. Our findings showed that AS-10 and AS-14 preserved the level of and the activities of antioxidant enzymes such as glutathione reductase, peroxidase, superoxide dismutase and catalase. |
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| 19899326 | Adaramoye OA: Comparative effects of and kolaviron (a biflavonoid from Garcinia kola) on carbon tetrachloride-induced renal oxidative damage in mice. Pak J Biol Sci. 2009 Aug 15;12(16):1146-51. Furthermore, CCl4-intoxication decreased the levels of renal (GSH), superoxide dismutase (SOD) and catalase (CAT) by 44, 56 and 43%, respectively. |
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| 17900780 | Yang YS, Ahn TH, Lee JC, Moon CJ, Kim SH, Jun W, Park SC, Kim HC, Kim JC: Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. Food Chem Toxicol. 2008 Jan;46(1):380-7. Epub 2007 Aug 21. Hepatotoxicity was assessed 24 h after the CCl4 treatment by measurement of serum aminotransferase (AST) and alanine aminotransferase (ALT) activities, hepatic malondialdehyde (MDA) and (GSH) concentrations, and catalase, superoxide dismutase (SOD), and glutathione-S-transferase (GST) activities. |
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| 19327381 | Khan MR, Ahmed D: Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat. Food Chem Toxicol. 2009 Jun;47(6):1393-9. Epub 2009 Mar 25. It also markedly increases the level of TBARS and nitrites along with corresponding decrease in and various antioxidant enzymes in testis, i.e., catalase, peroxidase, superoxide dismutase and peroxidase. |
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| 17686593 | Srinivasan R, Chandrasekar MJ, Nanjan MJ, Suresh B: Antioxidant activity of Caesalpinia digyna root. J Ethnopharmacol. 2007 Sep 5;113(2):284-91. Epub 2007 Jun 26. The CDM having the highest content of phenolic compounds and strong free radical scavenging effect when administered orally to male albino rats at 100, 200 and 400mg/kg body weight for 7 days, prior to carbontetrachloride (CCl (4)) treatment, caused a significant increase in the levels of catalase (CAT) and superoxide dismutase (SOD) and significant decrease in the levels of lipidperoxidation (LPO) in serum, liver and kidney in a dose dependent manner, when compared to CCl (4) treated control. |
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| 15089041 | Lee JY, Lee SH, Kim HJ, Ha JM, Lee SH, Lee JH, Ha BJ: The preventive inhibition of against the CCl4-induced oxidative stress of subcellular level. Arch Pharm Res. 2004 Mar;27(3):340-5. Our work in this study was made in the microsomal fraction to evaluate the lipid peroxidation by measuring superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx), and malondialdehyde (MDA) and to elucidate the preventive role of CS in the CCl4-induced oxidative stress. |
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| 16703270 | Noyan T, Komuroglu U, Bayram I, Sekeroglu MR: Comparison of the effects of and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice. Cell Biol Toxicol. 2006 Nov;22(6):381-91. Epub 2006 May 16. In the toxicity group, increased concentrations of malondialdehyde (MDA) and lipid hydroperoxides (LOOH) and decreased peroxidase (GSH-Px) and catalase (CAT) activities were found compared to the control and olive oil groups (p < 0.05). |
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| 16114493 | Singab AN, Youssef DT, Noaman E, Kotb S: Hepatoprotective effect of flavonol glycosides rich fraction from Egyptian Vicia calcarata Desf. against CCl4-induced liver damage in rats. Arch Pharm Res. 2005 Jul;28(7):791-8. The antioxidant activity of F-2 markedly ameliorated the antioxidant parameters including (GSH) content, peroxidase (GSH-Px), superoxide dismutase (SOD), plasma catalase (CAT) and packed erythrocytes glucose-6-phosphate dehydrogenase (G6PDH) to be comparable with normal control levels. |
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| 15991578 | Pradeep K, Mohan CV, Anand KG, Karthikeyan S: Effect of pretreatment of Cassia fistula Linn. leaf extract against subacute CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2005 Jun;43(6):526-30. CCl4 alone treatment (0.lml of liquid paraffin/100g body weight, ip) for 7 days followed by 0.l ml of CCl4 (in liquid parafiin/100g body weight, ip) from day 8 till day 14, caused a 16 fold increase in lipid peroxidation and a 50% reduction in catalase and glutathione reductase in liver tissue of rats accompanied by an increase in the activities of transaminases. alkaline phosphatase, lactate dehydrogenase and gamma - glutamyl transpeptidase in serum as compared to liquid paraffin treated control. |
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| 19540299 | Akowuah GA, Zhari I, Mariam A, Yam MF: Absorption of andrographolides from Andrographis paniculata and its effect on CCl (4)-induced oxidative stress in rats. Food Chem Toxicol. 2009 Sep;47(9):2321-6. Epub 2009 Jun 18. Fourteen days oral treatment of rats with the extract (1 g/kg body weight) followed by CCl (4) administration preserved catalase (CAT), and superoxide dismutase (SOD) activities in erythrocytes, whereas plasma lipid peroxidation, transaminase (ALT) and transaminase (AST) activities were restored to values comparable with control values. |
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| 19581077 | Adesanoye OA, Farombi EO: Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride. Exp Toxicol Pathol. 2010 Mar;62(2):197-206. Epub 2009 Jul 5. Similarly, administration of the extract increased the activities of the antioxidant enzymes: superoxide dismutase, glutathione S-transferase and concentration significantly at 500 mg/kg (P <0.05) and catalase activity at 500-1000 mg/kg doses. |
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| 19822030 | Ozturk F, Gul M, Ates B, Ozturk IC, Cetin A, Vardi N, Otlu A, Yilmaz I: Protective effect of apricot (Prunus armeniaca L.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar rats. J Med Food. 2005 Summer;8(2):261-5. Malondialdehyde and total levels and catalase, superoxide dismutase and peroxidase activities were significantly changed in the CCl4 group and indicated increased oxidative stress. |
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| 18761048 | Hsu YW, Tsai CF, Chang WH, Ho YC, Chen WK, Lu FJ: Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2008 Oct;46(10):3311-7. Epub 2008 Aug 12. CCl (4) induced liver damage and significantly (p <0.05) increased the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum and decreased the activities of superoxide dismutase (SOD), catalase, peroxidase (GSH-Px), and GSH content in liver whereas increased hepatic malondialdehyde (MDA) content as compared with control group. |
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| 16676162 | Young SC, Wang CJ, Lin JJ, Peng PL, Hsu JL, Chou FP: Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Arch Toxicol. 2007 Jan;81(1):45-55. Epub 2006 May 5. It also attenuated total glutathione S-transferase (GST) activity and GST alpha isoform activity, and on the other hand, enhanced superoxide dismutase (SOD) and catalase (CAT) activities. |
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| 17169472 | Rudnicki M, Silveira MM, Pereira TV, Oliveira MR, Reginatto FH, Dal-Pizzol F, Moreira JC: Protective effects of Passiflora alata extract pretreatment on carbon tetrachloride induced oxidative damage in rats. Food Chem Toxicol. 2008 Nov;46(11):3417-21. Epub 2008 Aug 22. The pretreatment with the P. alata extract provided significant protection to liver, evidenced by lower degree of necrosis, decreased lipid peroxidation (TBARS) and higher catalase and superoxide dismutase activities. |
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| 18697572 | Kuriakose GC, Kurup GM: Antioxidant activity of Aulosira fertilisima on CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2008 Jan;46(1):52-9. Carbon tetrachloride (CCl4) is used as a model for liver injury. Oral administration of EEA at a dose of 100 mg/kg body weight, for 14 consecutive days, the rate of the production of antioxidant enzymes like super oxide dismutase, catalase, peroxidase and glutathione transferase in rats compared to the CCl4 treated group without any supporting treatment. |
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| 14757943 | Abdellatif A, Al-Tonsy AH, Awad ME, Roberfroid M, Khan MN: Peroxisomal enzymes and in rat liver treated with perfluorooctanoic acid. Dis Markers. 2003-2004;19(1):19-25. In the middle of this treatment a single oral dose of carbon tetrachloride (2.0 ml/kg) was given, followed by giving diet containg 0.015% of PFOA for 25 weeks. After applying both protocols, our results showed slight increase in the catalase activity while acyl oxidase activity was markedly increased. |
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| 16316705 | Ma SF, Nishikawa M, Katsumi H, Yamashita F, Hashida M: Liver targeting of catalase by cationization for prevention of acute liver failure in mice. J Control Release. 2006 Jan 10;110(2):273-82. Epub 2005 Nov 28. |
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| 19041730 | Cuciureanu M, Caruntu ID, Paduraru O, Stoica B, Jerca L, Crauciuc E, Nechifor M: The protective effect of montelukast on carbon tetrachloride induced hepatopathy in rat. Prostaglandins Other Lipid Mediat. 2009 Apr;88(3-4):82-8. Epub 2008 Nov 11. One day after the last administration, samples of blood were taken and alanine aminotransferase (ALT), total (TB), direct (DB), malondialdehyde (MDA), catalase (CAT) as well as total antioxidant capacity (TAC) were determined. |
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| 15261760 | Taniguchi M, Takeuchi T, Nakatsuka R, Watanabe T, Sato K: Molecular process in acute liver injury and regeneration induced by carbon tetrachloride. Life Sci. 2004 Aug 13;75(13):1539-49. Down-regulation of liver-specific genes was accomplished through suppression of liver-enriched transcription factors and box A factors found in the catalase gene, and induction of NF-kappaB, AP-1 and a novel factor denoted as 'cx' in the catalase gene. |
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| 19857077 | Dani C, Oliboni LS, Umezu FM, Pasquali MA, Salvador M, Moreira JC, Henriques JA: Antioxidant and antigenotoxic activities of purple grape juice--organic and conventional--in adult rats. J Med Food. 2009 Oct;12(5):1111-8. The aim of this study was to evaluate the protection of organic and conventional purple grape juices in brain, liver, and plasma from adult Wistar rats (7 months old) against the oxidative damage provoked by carbon tetrachloride (CCl (4)). CCl (4) caused an increase in catalase activity in cerebral cortex, hippocampus, and substantia nigra and in superoxide dismutase activity in substantia nigra. |
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| 18436364 | Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG: Protective effect of phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 2008 Jun 3;248(1):18-24. Epub 2008 Mar 20. In addition, CAPE attenuated the CCl (4)-mediated depletion of antioxidant enzyme (catalase, superoxide dismutase and glutathione-S-transferase) activities. |
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| 17803529 | Subramanian P, Mirunalini S, Dakshayani KB, Pandi-Perumal SR, Trakht I, Cardinali DP: Prevention by of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine. J Pineal Res. 2007 Oct;43(3):305-12. To evaluate the chemopreventive function of in this experimental model, Wistar male rats received a single i.p. injection of NDEA or vehicle followed by weekly s.c. injections of carbon tetrachloride or vehicle for 6 weeks. The activity of superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx) and glutathione S-transferase (GST) was assessed in liver and erythrocyte fraction of NDEA-treated rats. |
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| 15320500 | Satturwar PM, Fulzele SV, Joshi SB, Dorle AK: Hepatoprotective activity of Haridradi ghrita on carbon tetrachloride-induced liver damage in rats. Indian J Exp Biol. 2003 Dec;41(12):1447-51. Haridradi ghrita, a ghee based polyherbal formulation, (50, 100, 200 and 300 mg/kg) significantly lowered marker enzymes (SGPT, SGOT, ALP) and in serum and liver peroxide, superoxide dismutase and catalase in liver homogenate following CCl4 (0.7 ml/kg, ip) toxicity. |
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| 17611085 | Manna P, Sinha M, Sil PC: Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress. J Appl Toxicol. 2009 Mar;29(2):156-64. Oral administration of CCl (4) at a dose of 1ml/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST), as well as depleted the level of (GSH) in the cardiac tissue. |
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| 18361748 | Dani C, Oliboni LS, Pasquali MA, Oliveira MR, Umezu FM, Salvador M, Moreira JC, Henriques JA: Intake of purple grape juice as a hepatoprotective agent in Wistar rats. Pathophysiology. 2007 Oct;14(2):71-8. Epub 2007 Jul 3. After 30 days, all animals were sacrificed, and blood and liver were collected to evaluate lipid peroxidation level (thiobarbituric acid-reactive substances [TBARS] assay), protein oxidative level (carbonyl assay), and catalase (CAT) and superoxide dismutase (SOD) activities. |
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| 19775072 | Hegde K, Joshi AB: Hepatoprotective effect of Carissa carandas Linn root extract against CCl4 and induced hepatic oxidative stress. Indian J Exp Biol. 2009 Aug;47(8):660-7. Oral pre-treatment with ethanolic extract of the roots of C. carandas (ERCC; 100, 200 and 400 mg/kg, po) showed significant hepatoprotective activity against CCl4 and induced hepatotoxicity by decreasing the activities of serum marker enzymes, and lipid peroxidation, and significant increase in the levels of super oxide dismutase, catalase and protein in a dose dependent manner, which was confirmed by the decrease in the total weight of the liver and histopathological examination. |
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| 20035854 | Peng WH, Tien YC, Huang CY, Huang TH, Liao JC, Kuo CL, Lin YC: Fraxinus rhynchophylla extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. J Ethnopharmacol. 2010 Feb 17;127(3):606-13. Epub 2009 Dec 24. Liver function parameters (such as activities of serum GOT and GPT levels), activities of liver anti-oxidant enzymes (such as catalase, SOD, GPx) and expressions of uPA, tPA, MMP-2, MMP-9 and TIMP-1, -2, -3, -4 in the liver fibrosis pathway were detected. |
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| 19524009 | Hsu YW, Tsai CF, Chen WK, Lu FJ: Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2009 Sep;47(9):2281-8. Epub 2009 Jun 11. Moreover, the treatment of SBT seed oil was also found to significantly increase the activities of superoxide dismutase (SOD), catalase, peroxidase (GSH-Px), glutathione reductase (GSH-Rd), and GSH content in liver up to 134%. |
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| 17706384 | Padhy BM, Srivastava A, Kumar VL: Calotropis procera latex affords protection against carbon tetrachloride induced hepatotoxicity in rats. J Ethnopharmacol. 2007 Sep 25;113(3):498-502. Epub 2007 Jul 10. Histological analysis of the liver of these rats revealed marked necro-inflammatory changes that were associated with increase in the levels of TBARS, PGE (2) and catalase and decrease in the levels of (GSH), superoxide dismutase (SOD) and peroxidase (GPx). |
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| 17355462 | Naik SR, Panda VS: Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents. Fitoterapia. 2010 Jan;81(1):1-7. Epub 2009 Jul 8. Further, the effects of GBP on lipid peroxidation (LPO), (GSH), superoxide dismutase (SOD), catalase (CAT), peroxidase (GPX) and glutathione reductase (GR) were estimated in liver homogenates to evaluate antioxidant activity. |
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| 19477216 | Tsai CF, Hsu YW, Chen WK, Chang WH, Yen CC, Ho YC, Lu FJ: Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2009 Aug;47(8):2031-6. Epub 2009 May 27. By contrast, ERW or silymarin supplement significantly ameliorated the CCl (4)-induced liver lesions, lowered the serum levels of hepatic enzyme markers (ALT and AST) and increased the activities of SOD, catalase, and GSH-Px in liver. |
1(0,0,0,1) | Details |
| 15022720 | Jung SH, Lee YS, Lim SS, Lee S, Shin KH, Kim YS: Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis on carbon tetrachloride-induced hepatic injury in rats. Arch Pharm Res. 2004 Feb;27(2):184-8. Both compounds also showed strong increase in the antioxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and peroxidase -px) activities in CCl4-intoxicated rats. |
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| 19621136 | Moselhy SS, Ali HK: Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biol Res. 2009;42(1):93-8. Epub 2009 Jun 11. There was a significant elevation in the level of liver malondialdhyde (MDA), while the activities of antioxidant enzymes superoxide dismutase and catalase (SOD and CAT) were significantly decreased in CC1 (4) intoxicated rats. |
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| 20020986 | Bhattacharjee R, Sil PC: Protein Isolate from the Herb Phyllanthus niruri Modulates Carbon Tetrachloride-Induced Cytotoxicity in Hepatocytes. Toxicol Mech Methods. 2007;17(1):41-7. Administration of CCl (4) increased the leakage of glutamate pyruvate transaminase (GPT) by four fold and lactate dehydrogenase (LDH) by 84% in cell suspension, along with increased lipid peroxidation (114%), and reduced the levels of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) to almost 30% and 37% of the normal values, respectively. |
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| 17202657 | Wang CY, Ma FL, Liu JT, Tian JW, Fu FH: Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats. Biol Pharm Bull. 2007 Jan;30(1):44-7. Spectrophotometrical method was used to measure activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum, activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (GPx) as well as malondialdehyde (MDA) level in hepatic tissue and the rate of (O2*-) generation in hepatic submitochondrial particles. |
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| 15683547 | Tirkey N, Pilkhwal S, Kuhad A, Chopra K: a citrus decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol. 2005 Jan 31;5:2. Oxidative stress in liver and kidney tissue was estimated using Thiobarbituric acid reactive substances (TBARS), (GSH) content, superoxide dismutase (SOD), and Catalase (CAT) RESULTS: CCl4 caused a marked rise in serum levels of ALT and AST (P < 0.05). |
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| 15943754 | Kamalakkannan N, Rukkumani R, Varma PS, Viswanathan P, Rajasekharan KN, Menon VP: Comparative effects of and an analogue of in carbon tetrachloride-induced hepatotoxicity in rats. Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):15-21. There was a significant (P <0.05) increase in the levels of TBARS and hydroperoxides in liver and kidney and a significant (P <0.05) decrease in the activities of enzymic antioxidants- superoxide dismutase (SOD), catalase and GSH peroxidase along with GSH in CCl (4)-treated rats. |
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| 18416106 | Semenova EV, Inchina VI: [Study of hepatoprotective activity of ethylmethylhydroxypyridine and in the experimental toxic hepatitis]. Eksp Klin Gastroenterol. 2007;(6):122-5 The cytolytic contents activity, catalase activity and the level of MDA have been determined in blood serum. |
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| 15036469 | Bhandarkar MR, Khan A: Antihepatotoxic effect of Nymphaea stellata willd., against carbon tetrachloride-induced hepatic damage in albino rats. J Ethnopharmacol. 2004 Mar;91(1):61-4. The oral administration of varying dosage of extract of Nymphaea stellata willd., flower to rats for 10 days afforded the good hepatoprotection against carbon tetrachloride-induced elevation in serum marker enzymes, serum liver lipid peroxidation and reduction in liver liver peroxidase, superoxide dismutase and catalase activity. |
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| 19449806 | Murugan V, Mukherjee K, Maiti K, Mukherjee PK: Enhanced oral bioavailability and antioxidant profile of by phospholipids. J Agric Food Chem. 2009 Jun 10;57(11):4559-65. The complex significantly protected the liver by restoring the activity of superoxide dismutase, catalase and liver and thiobarbituric acid reactive substances with respect to the carbon tetrachloride treated group (P < 0.05 and < 0.01). |
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| 18652820 | Salazar-Montes A, Ruiz-Corro L, Lopez-Reyes A, Castrejon-Gomez E, Armendariz-Borunda J: Potent antioxidant role of pirfenidone in experimental cirrhosis. . Eur J Pharmacol. 2008 Oct 24;595(1-3):69-77. Epub 2008 Jul 9. Cirrhosis was induced in rats by ligation of the common bile duct or carbon tetrachloride (CCl (4)) chronic intoxication and treated with pirfenidone or diphenyleneiodonium (a potent known antioxidant) for the last two weeks for bile duct ligation model or for the last three weeks for CCl (4) chronic intoxication. Superoxide dismutase (SOD), catalase (CAT) and inducible synthase (iNOS) gene expression were importantly down-regulated where nuclear factor kappa B (NF-kappaB) binding activity also decreased with pirfenidone treatment. |
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| 15963578 | Krasnov A, Koskinen H, Rexroad C, Afanasyev S, Molsa H, Oikari A: Transcriptome responses to carbon tetrachloride and pyrene in the kidney and liver of juvenile rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 2005 Aug 15;74(1):70-81. For instance, stimulation of mitochondrial proteins coincided with suppression of catalase, whereas CCl (4) down-regulated fatty acid metabolism and peroxisomal proteins. |
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| 15619574 | Ha KT, Yoon SJ, Choi DY, Kim DW, Kim JK, Kim CH: Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. Food Chem Toxicol. 2007 Apr;45(4):656-61. Epub 2006 Nov 2. In addition, pretreatment of LFE prevented the elevation of hepatic malondialdehyde (MDA) formation and the depletion of (GSH) content and catalase activity in the liver of CCl (4)-injected rats. |
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| 20219667 | Akindele AJ, Ezenwanebe KO, Anunobi CC, Adeyemi OO: Hepatoprotective and in vivo antioxidant effects of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae). Liver Int. 2007 Apr;27(3):393-9. CCl (4) also produced significant (P <0.05) reductions in the activity of catalase, SOD, peroxidase and GSH, and conversely increased MDA level. AIM OF THE STUDY: To investigate the hepatoprotective and in vivo antioxidant effects of B. coccineus in carbon tetrachloride (CCl (4))-induced hepatotoxicity in rats. |
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| 19405380 | Preethi KC, Kuttan R: Hepato and reno protective action of Calendula officinalis L. flower extract. Indian J Exp Biol. 2009 Mar;47(3):163-8. Treatment with the extract produced enhancement of antioxidant enzymes--superoxide dismutase and catalase and |
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| 19702266 | Hsu JD, Kao SH, Tu CC, Li YJ, Wang CJ: Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes. Indian J Exp Biol. 2005 May;43(5):437-44. Our previous study has found that SN water extract (SNWE) alleviated carbon tetrachloride-induced liver damage in rats. Further investigation revealed that a SNWE supplement increased the expression of glutathione S-transferase-alpha and -mu, the level of transcription factor for protection from oxidative stress, Nrf2, and the level of downstream targets regulated by Nrf2, including peroxidase, superoxide dismutase-1, and catalase. |
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| 17112692 | Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK: -phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. J Ethnopharmacol. 2010 Feb 25. -phospholipid complex significantly protected the liver by restoring the enzyme levels of liver system and that of superoxide dismutase, catalase and thiobarbituric acid reactive substances with respect to carbon tetrachloride treated group (P < 0.05 and <0.01). |
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| 15133295 | Yamaoka K, Kataoka T, Nomura T, Taguchi T, Wang DH, Mori S, Hanamoto K, Kira S: Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice. J Radiat Res. 2004 Mar;45(1):89-95. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high peroxidase activity and low-dose irradiation in the acatalasemic mouse liver. |
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| 19118616 | Khan MR, Rizvi W, Khan GN, Khan RA, Shaheen S: Carbon tetrachloride-induced nephrotoxicity in rats: protective role of Digera muricata. J Ethnopharmacol. 2009 Feb 25;122(1):91-9. Epub 2008 Dec 11. Activity of antioxidant enzymes; catalase, peroxidase, superoxide dismutase and (GSH) were decreased while thiobarbituric acid reactive substances (TBARSs) were increased with CCl (4) treatment. |
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| 19294768 | Al-Rejaie SS, Aleisa AM, Al-Yahya AA, Bakheet SA, Alsheikh A, Fatani AG, Al-Shabanah OA, Sayed-Ahmed MM: Progression of diethylnitrosamine-induced hepatic carcinogenesis in -depleted rats. World J Gastroenterol. 2009 Mar 21;15(11):1373-80. RESULTS: Administration of DENA resulted in a significant increase in transaminase (ALT), gamma-glutamyl transferase (G-GT), alkaline phosphatase (ALP), total thiobarbituric acid reactive substances (TBARS) and total / (NOx) and a significant decrease in (GSH), peroxidase (GSHPx), catalase (CAT) and total content in liver tissues. Rats in group 4 (DENA group) were injected with a single dose of DENA (200 mg/kg, i.p.) and 2 wk later received a single dose of carbon tetrachloride (2 mL/kg) by gavage as 1:1 dilution in corn oil. |
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| 16914248 | Jayakumar T, Ramesh E, Geraldine P: Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl (4)-induced liver injury in rats. Food Chem Toxicol. 2006 Dec;44(12):1989-96. Epub 2006 Jul 12. Quantitative and qualitative analysis of catalase (CAT), superoxide dismutase (SOD) and peroxidase (Gpx) revealed lower activities of these antioxidant enzymes in the liver of CCl (4)-administered rats. |
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| 19779110 | Peng HY, Chu YC, Chen SJ, Chou ST: Hepatoprotection of chlorella against carbon tetrachloride-induced oxidative damage in rats. In Vivo. 2009 Sep-Oct;23(5):747-54. The reduced levels of superoxide dismutase, and catalase in the CCl (4)-treated rats were significantly increased by treatment with GPE. |
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| 15997120 | Tasduq SA, Mondhe DM, Gupta DK, Baleshwar M, Johri RK: Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug. Biol Pharm Bull. 2005 Jul;28(7):1304-6. A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Hepatic parameters monitored were the levels of lipid peroxidation (LPO) and and the activities of catalase, peroxidase (GPx), Na+,K+-ATPase and cytochrome P450 (CYP 450 2E1) hydroxylation). |
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| 19913046 | Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY: Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):318-25. Epub 2009 Nov 11. The hepatoprotective effect of ginsan was attributed to induction of anti-oxidant protein contents, such as superoxide dismutase (SOD), catalase, and peroxidase (GPX) as well as restoration of the hepatic (GSH) concentration. |
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| 18482221 | Hort MA, Dalbo S, Brighente IM, Pizzolatti MG, Pedrosa RC, Ribeiro-do-Valle RM: Antioxidant and hepatoprotective effects of Cyathea phalerata Mart. (Cyatheaceae). Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):17-24. Epub 2008 Jul 1. The in vivo evaluation of oxidative stress (DNA fragmentation, membrane lipoperoxidation and carbonyl protein formation) and the antioxidant defenses (concentration of as well as catalase and glutathione S-transferase activities) were measured in mice pre-treated with EAF (10, 30 or 100 mg/kg, orally) and later exposed to carbon tetrachloride (CCl (4)). |
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| 20021039 | Dhawan D, Sen T, Dani V: Effectiveness of in Modulating the CCl (4) - Induced Oxidative Stress in Rat Liver. Toxicol Mech Methods. 2006;16(1):37-40. However, the activities of catalase and peroxidase, which were increased under carbon tetrachloride treatment, were significantly attenuated and tended to become normal. |
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| 17022372 | Kataoka T, Nomura T, Wang DH, Taguchi T, Yamaoka K: Effects of post low-dose X-ray irradiation on carbon tetrachloride-induced acatalasemic mice liver damage. Physiol Chem Phys Med NMR. 2005;37(2):109-26. These findings suggest that low-dose irradiation after carbon tetrachloride administration accelerates the rate of recovery and that catalase plays an important role in the recovery from hepatopathy induced by carbon tetrachloride, in contrast to high-dose irradiation. |
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| 16393475 | Lee SJ, Oh PS, Ko JH, Lim K, Lim KT: Protective effect of glycoprotein isolated from Ulmus davidiana Nakai on carbon tetrachloride-induced mouse liver injury. J Pharm Pharmacol. 2006 Jan;58(1):143-52. We evaluated lipid peroxidation in / oxidase (G/GO)-induced BNL CL.2 cells and measured thiobarbituric acid reactive substances (TBARS), lactate dehydrogenase (LDH), (NO), antioxidant enzyme (superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx)), activity of cytotoxic-related signals (hepatic cytochrome c, nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1)) and levels of plasma lipids (triglyceride (TG) and total (TC)) in carbon tetrachloride (CCl (4,) 1.0 mL kg (-1))-induced A/J mouse. |
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| 18830880 | Khan TH, Sultana S: Antioxidant and hepatoprotective potential of Aegle marmelos Correa. against CCl4-induced oxidative stress and early tumor events. J Enzyme Inhib Med Chem. 2009 Apr;24(2):320-7. Hepatic antioxidant status viz, (GSH), glutathione reductase (GR), peroxidase (GPx), quinone reductase (QR), catalase (CAT) were concomitantly restored in A. marmelos-treated groups (p < 0.001). In conclusion, carbon tetrachloride-induced liver toxicity was strikingly attenuated by A. marmelos treatment and the study gives some insight into the mechanisms involved in diminution of free radical generating toxicants and enhancement of the antioxidant armory, hence preventing further tissue damage, injury and hyperproliferation. |
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| 19304561 | Lodhi G, Singh HK, Pant KK, Hussain Z: Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats. Acta Pharm. 2009 Mar;59(1):89-96. Various biochemical parameters such as amino transferase (AST), amino transferase (ALT), (GSH), lipid peroxide (LPO), superoxidedismutase (SOD), peroxidase (GPx) and catalase (CAT) were evaluated. |
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| 18440118 | Soni B, Visavadiya NP, Madamwar D: Ameliorative action of cyanobacterial phycoerythrin on CCl (4)-induced toxicity in rats. J Med Food. 2008 Mar;11(1):127-32. Carbon tetrachloride (CCl (4)) is largely used as solvent in chemical industries. Hepatic and renal tissues showed significant decline (P <0.05) in malondialdehyde, lipid hydroperoxides and conjugated dienes with rise in SOD, catalase, GPx, GSH, and levels. |
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| 16823256 | Ko JH, Lim KT: Glycoprotein isolated from Ulmus davidiana NAKAI protects against carbon tetrachloride-induced liver injury in the mouse. J Pharmacol Sci. 2006 Jul;101(3):205-13. Epub 2006 Jul 6. We evaluated the activities of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), thiobarbituric acid-reactive substances (TBARS), and antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx)] activities in CCl4-treated mice. |
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| 16239089 | Rai S, Wahile A, Mukherjee K, Saha BP, Mukherjee PK: Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds. J Ethnopharmacol. 2006 Apr 6;104(3):322-7. Epub 2005 Oct 18. Administration of HANN to Wistar rats at 100 and 200 mg/kg body weight for 4 days prior to carbon tetrachloride (CCl (4)) treatment caused a significant dose dependent increase (p < 0.05 to p < 0.001) in the level of superoxide dismutase (SOD) and catalase and a significant decrease (p < 0.05 to p < 0.001) in the level of thiobarbituric acid reactive substances (TBARS), when compared to CCl (4) treated control in both liver and kidney. |
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| 16909447 | Nkosi CZ, Opoku AR, Terblanche SE: Antioxidative effects of pumpkin seed (Cucurbita pepo) protein isolate in CCl4-induced liver injury in low-protein fed rats. Toxicology. 2008 Jun 3;248(1):59-65. Epub 2008 Mar 18. The effects of pumpkin seed (Cucurbita pepo) protein isolate on the plasma activity levels of catalase (CA), superoxide dismutase (SOD), peroxidase (GSHpx) and total antioxidant capacity (TAC) as well as glucose-6-phosphatase (G6Pase) in liver homogenates and lipid peroxidation (LPO-malondialdehyde-MDA) levels in liver homogenates and liver microsomal fractions against carbon tetrachloride (CCl (4))-induced acute liver injury in low-protein fed Sprague-Dawley rats (Rattus norvegicus) were investigated. |
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| 16438391 | Ramkumar KM, Anuradha CV: Short-term dietary restriction modulates liver lipid peroxidation in carbon tetrachloride-intoxicated rats. J Basic Clin Physiol Pharmacol. 2005;16(4):245-56. The enzymic antioxidants superoxide dismutase, catalase, peroxidase and the non-enzymic antioxidant were significantly increased in both groups. |
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| 14992325 | Tasaduq SA, Singh K, Sethi S, Sharma SC, Bedi KL, Singh J, Jaggi BS, Johri RK: Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine. Hum Exp Toxicol. 2003 Dec;22(12):639-45. HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. HP-1 attenuated the serum toxicity as manifested in elevated levels of transaminases transaminase (GOT), and GPT) The antioxidative enzymes in liver (catalase and superoxide dismutase (SOD)) were restored to normal values after the oral administration of HP-1. |
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| 20138953 | Lee BJ, Senevirathne M, Kim JS, Kim YM, Lee MS, Jeong MH, Kang YM, Kim JI, Nam BH, Ahn CB, Je JY: Protective effect of fermented sea tangle against and carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats. Food Chem Toxicol. 2010 Apr;48(4):1123-8. Epub 2010 Feb 6. Hepatotoxicity was evaluated by measuring the serum levels of glutamic transaminase (GPT), gamma glutamyl transpeptidase (gamma-GT) and malondialdehyde (MDA) as well as the tissue levels of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx). |
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| 19327382 | Tung YT, Wu JH, Huang CC, Peng HC, Chen YL, Yang SC, Chang ST: Protective effect of Acacia confusa bark extract and its active compound against carbon tetrachloride-induced chronic liver injury in rats. Food Chem Toxicol. 2009 Jun;47(6):1385-92. Epub 2009 Mar 25. CCl (4)-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), peroxidase (GPX) and catalase (CAT) in erythrocytes. |
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| 15489557 | Shahjahan M, Sabitha KE, Jainu M, Shyamala Devi CS: Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats. Int J Pharm. 2007 Feb 7;330(1-2):155-63. Epub 2006 Sep 23. Lipid peroxidation (LP) was increased significant in liver tissue in the CCl4 treated rats (group II) while the activities of peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were decreased. |
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| 18664124 | Bezborodkina NN, Okovityi SV, Kudriavtseva MV, Kirik OV, Zarubina IV, Kudriavtsev BN: [Morphometry of hepatocyte mitochondrial apparatus in normal and cirrhotic rat liver]. Tsitologiia. 2008;50(3):228-36. Activities of superoxide dismutase and catalase in the cirrhotic liver were lower than in the normal liver were lower than in the normal liver by 16 and 23 %, respectively. |
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| 15900909 | Augusti KT, Anuradha, Prabha SP, Smitha KB, Sudheesh M, George A, Joseph MC: Nutraceutical effects of garlic oil, its nonpolar fraction and a Ficus as compared to in CCl4 induced liver damage in rats. Indian J Med Res. 2004 Sep;120(3):194-8. Carbon tetrachloride feeding (3.2g/kg/72hr) for one month increased significantly the serum and tissue lipid profile and deranged the enzyme levels viz; alkaline phosphatase, transaminase, transaminase, glutathionze reductase, HMGCoA reductase, catalase, gluc.6.PDH and malic enzyme in rats. |
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| 17963319 | Chang HY, Peng WH, Sheu MJ, Huang GJ, Tseng MC, Lai MT, Ho YL, Chang YS: Hepatoprotective and Antioxidant Effects of Extract from Phellinus merrillii on carbon tetrachloride-induced liver damage. Am J Chin Med. 2007;35(5):793-804. Carbon tetrachloride induces up-regulation of antioxidant enzymes, including superoxide dismutase (SOD) (86.6%), catalase (58.8%) and peroxidase (GPx)(64.7%) in the liver. |
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| 20350579 | Hsu YW, Tsai CF, Chuang WC, Chen WK, Ho YC, Lu FJ: Protective effects of hydride against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2010 Mar 26. Moreover, the -hydride treatment was also found to significantly increase the activities of superoxide dismutase (SOD), catalase, and peroxidase (GSH-Px), as well as increase the GSH content, in the liver. |
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| 17175085 | Bhattacharjee R, Sil PC: Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Dig Dis Sci. 2007 Oct;52(10):2616-21. Epub 2007 Apr 12. Administration of CCl (4) increased the serum glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels of mice sera along with increased lipid peroxidation and reduced levels of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the liver. |
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| 15511216 | Das RK, Das S, Bhattacharya S: Protective effect of diphenylmethyl selenocyanate against carbon tetrachloride-induced hepatotoxicity in vivo. J Environ Pathol Toxicol Oncol. 2004;23(4):287-96. Treatment with Se compound was found to upregulate different phase II detoxifying enzymes (catalase, superoxide dismutases, and glutathione transferase) in liver of mice challenged with different doses of CCl (4) as compared to the CCl (4) control, when measured after 24 hours of CCl (4) treatment (p < 0.01). |
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| 17010209 | Manna P, Sinha M, Sil PC: Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement Altern Med. 2006 Sep 30;6:33. Antioxidant status in both the liver and kidney tissues were estimated by determining the activities of the antioxidative enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST); as well as by determining the levels of thiobarbutaric acid reactive substances (TBARS) and reduced glutathione (GSH). |
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| 18022343 | Lee SJ, Lim KT: Glycoprotein of Zanthoxylum piperitum DC has a hepatoprotective effect via anti-oxidative character in vivo and in vitro. Toxicol In Vitro. 2008 Mar;22(2):376-85. Epub 2007 Oct 14. In addition, administration of ZPDC glycoprotein (20mg/kg) lowers the levels of lactate dehydrogenase, transaminase, and thiobarbituric acid reactive substances, whereas increases that of accompanying the normalizing effects on the activity of hepatic anti-oxidant enzymes (superoxide dismutase, catalase, and peroxidase) in mouse model of carbon tetrachloride-stimulated acute liver injury. |
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| 16719498 | Rajesha J, Murthy KN, Kumar MK, Madhusudhan B, Ravishankar GA: Antioxidant potentials of flaxseed by in vivo model. J Agric Food Chem. 2006 May 31;54(11):3794-9. Activity was assessed by measuring hepatic marker enzymes like catalase, superoxide dismutase (SOD), and peroxidase and comparing with those from the normal group and from a group receiving toxin without flaxseed. |
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| 15670617 | Chidambara Murthy KN, Vanitha A, Rajesha J, Mahadeva Swamy M, Sowmya PR, Ravishankar GA: In vivo antioxidant activity of carotenoids from Dunaliella salina--a green microalga. Life Sci. 2005 Feb 4;76(12):1381-90. Epub 2005 Jan 18. Treatment of CCl4 at dose of 2.0 g/kg b.w. decreased the activities of various antioxidant enzymes like catalase, superoxide dismutase (SOD) and peroxidase by 45.9%, 56% and 54% respectively compared to control group and lipid peroxidation value increased nearly 2 folds. |
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| 19152825 | Mohammadi M, Yazdanparast R: Methoxy VO-salen complex: in vitro antioxidant activity, cytotoxicity evaluation and protective effect on CCl4-induced oxidative stress in rats. Food Chem Toxicol. 2009 Apr;47(4):716-21. Epub 2008 Dec 29. In an in vivo approach, the protective effect of MetVO-salen against CCl (4)-induced oxidative stress in rats was also investigated in terms of superoxide dismutase (SOD) and catalase (CAT) activities, as well as in terms of the levels of malondialdehyde (MDA) and glutathione (GSH). |
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| 19596425 | Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY: Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. Food Chem Toxicol. 2007 May;45(5):817-26. Epub 2006 Nov 11. A herbal preparation "Compound Codyceps-TCM-700C (CC-700C)" was tested for hepatoprotective effect against the carbon tetrachloride induced liver damages in Sprague-Dawley rat model for a period of 6-weeks. In contrast, the activity of catalase efficiently recovered to control level on administration of CC-700C, being far better than Silymarin. |
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| 18538978 | Veigas JM, Shrivasthava R, Neelwarne B: Efficient amelioration of carbon tetrachloride induced toxicity in isolated rat hepatocytes by Syzygium cumini Skeels extract. Toxicol In Vitro. 2008 Sep;22(6):1440-6. Epub 2008 Apr 29. Both peel and pulp extract appear to offer protection to rat hepatocytes through GPx along with other biological pathways independent of catalase and superoxide dismutase. |
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| 16011737 | Srinivasan M, Rukkumani R, Ram Sudheer A, Menon VP: a natural protector against carbon tetrachloride-induced toxicity. Fundam Clin Pharmacol. 2005 Aug;19(4):491-6. The activities of liver markers transaminase, transaminase, alkaline phosphatase, gamma-glutamyl transferase), lipid peroxidative index (thiobarbituric acid-reactive substances, hydroperoxides, protein carbonyl content), the antioxidant status (superoxide dismutase, catalase, peroxidase and were used as biomarkers to monitor the protective role of FA. |
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| 18489120 | Dani C, Bonatto D, Salvador M, Pereira MD, Henriques JA, Eleutherio E: Antioxidant protection of and in Saccharomyces cerevisiae. J Agric Food Chem. 2008 Jun 11;56(11):4268-72. Epub 2008 May 20. In this work, the capacity of and to protect the eukaryotic microorganism Saccharomyces cerevisiae against oxidative stress caused by different agents, peroxide, carbon tetrachloride, and cadmium, was evaluated. By using mutant strains deficient in specific antioxidant defense systems (superoxide dismutases, catalase, or it was observed that increased H2O2 tolerance produced by both polyphenols was associated with catalase, as well as the rise in survival rates caused by under CCl4. |
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| 14969415 | Jeon TI, Hwang SG, Lim BO, Park DK: Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats. Biotechnol Lett. 2003 Dec;25(24):2093-6. Catalase and superoxide dismutase activities were significantly decreased to 55% and 39% by CCl4 administration, but EPB blocked this effect, resulting in enzyme activities at control levels. |
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| 19345075 | Yan F, Zhang QY, Jiao L, Han T, Zhang H, Qin LP, Khalid R: Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats. Phytomedicine. 2009 Sep;16(9):805-13. Epub 2009 Apr 2. In the liver, significantly elevated levels (p <0.001) of malondialdehyde (MDA), lowered levels of (GSH) (p <0.05) and catalase (CAT) (p <0.001), superoxide dismutase (SOD) (p <0.01) were observed following CCl (4) administration. 'LFS+ASP' treatment of rats at doses of 'LFS (45mg/kg)+APS (150mg/kg)' and 'LFS (135mg/kg)+APS (450mg/kg)' displayed hepatoprotective and antioxidative effects than the administration of either LFS or APS, as evident by lower (p <0.005 or 0.001) levels of serum ALT, AST, ALP and hepatic MDA (p <0.001) concentration, as well as higher SOD (p <0.05 or 0.005), CAT activities (p <0.01 or 0.005), GSH concentration (p <0.05 or 0.005) compared to the toxin treated group. |
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