Protein Information

Name SALP
Synonyms Etle; Etoile; KHDRBS 3; KHDRBS3; RNA binding protein T Star; SALP; SLM 2; SLM2…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
16213120 Rao GM, Rao CV, Pushpangadan P, Shirwaikar A: Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006 Feb 20;103(3):484-90. Epub 2005 Oct 5.

The substantially elevated serum enzymatic activities of serum glutamic oxaloacetic transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP) and gamma-glutamyltransferase (gamma-GT) due to carbon tetrachloride treatment were dose dependently restored towards normalization.
6(0,0,1,1) Details
16914248 Jayakumar T, Ramesh E, Geraldine P: Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl (4)-induced liver injury in rats. Food Chem Toxicol. 2006 Dec;44(12):1989-96. Epub 2006 Jul 12.


Intraperitoneal administration of CCl (4) (2ml/kg) to rats for 4 days resulted in significantly elevated (p <0.05) serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvate transaminase (SGPT) and alkaline phosphatase (SALP) compared to controls.
2(0,0,0,2) Details
19581077 Adesanoye OA, Farombi EO: Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride. Exp Toxicol Pathol. 2010 Mar;62(2):197-206. Epub 2009 Jul 5.

Oral administration of CCl (4) at a dose of 1.2g/kg body weight 3 times a week for 3 weeks significantly induced marked hepatic injury as revealed by increased activity of the serum enzymes ALT, AST, SALP and gamma-GT.
1(0,0,0,1) Details
18783728 Zeashan H, Amresh G, Singh S, Rao CV: Hepatoprotective activity of Amaranthus spinosus in experimental animals. Food Chem Toxicol. 2008 Nov;46(11):3417-21. Epub 2008 Aug 22.

The hepatoprotective and antioxidant activity of 50% ethanolic extract of whole plant of Amaranthus spinosus (ASE) was evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats.
The substantially elevated serum enzymatic levels of serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (SALP) and total bilirubin were restored towards normalization significantly by the ASE in a dose dependent manner.
1(0,0,0,1) Details
17983713 Jain A, Soni M, Deb L, Jain A, Rout SP, Gupta VB, Krishna KL: Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves. J Ethnopharmacol. 2008 Jan 4;115(1):61-6. Epub 2007 Sep 19.

In present study, the hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves were evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats.
The substantially elevated serum enzymatic levels of serum glutamate oxaloacetate transaminase (AST), serum glutamate pyruvate transaminase (ALT), serum alkaline phosphatase (SALP) and total bilirubin were restored towards normalization significantly by the extracts.
1(0,0,0,1) Details
17355462 Naik SR, Panda VS: Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents. Liver Int. 2007 Apr;27(3):393-9.

The degree of protection was evaluated by determining the marker enzymes (SGOT, SGPT and SALP), albumin (Alb) and total proteins (TP).
1(0,0,0,1) Details