Protein Information

Name CD44
Synonyms CD44; LHR; Heparan sulfate proteoglycan; CD44 antigen; CD44 antigen (Indian blood group); CD44 antigen (homing function and Indian blood group system); CD44 antigen precursor; CD44 molecule (Indian blood group)…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
18395288 Kimura K, Nagaki M, Kakimi K, Saio M, Saeki T, Okuda Y, Kuwata K, Moriwaki H: Critical role of CD44 in hepatotoxin-mediated liver injury. J Hepatol. 2008 Jun;48(6):952-61. Epub 2008 Mar 11.

METHODS: We used CD44-deficient mice to assess whether inhibition of CD44 could control liver injury caused by carbon tetrachloride (CCl (4)).
84(1,1,1,4) Details
18721153 Kimura K, Nagaki M, Matsuura T, Moriwaki H, Kakimi K: Pathological role of CD44 on NKT cells in carbon tetrachloride-mediated liver injury. Hepatol Res. 2009 Jan;39(1):93-105. Epub 2008 Aug 19.
43(0,1,2,8) Details
19756695 Chiu CC, Sheu JC, Chen CH, Lee CZ, Chiou LL, Chou SH, Huang GT, Lee HS: Global gene expression profiling reveals a key role of CD44 in hepatic oval-cell reaction after 2-AAF/CCl4 injury in rodents. Histochem Cell Biol. 2009 Nov;132(5):479-89.

In this study, we treated rats with 2-acetylaminofluorene/carbon tetrachloride to induce hepatic oval cells.
6(0,0,0,6) Details
16109558 Xiang GA, Zhang GQ, Fang CH, Gao P, Chen KY: [A preliminary study of the homing capacity of allograft mesenchymal stem cells to rat liver]. Di Yi Jun Yi Da Xue Xue Bao. 2005 Aug;25(8):994-7.

The MSCs were identified by the monoclonal antibodies of CD29, CD44, CD34, CD45, CD90, SH-2 and SH-3 followed by transfection with a GFP retroviral vector.
After ex vivo expansion, the transfected MSCs were infused through the tail vein or portal veins of rats, some of which were subjected to treatment with carbon tetrachloride (CCl (4)) to induce centrolobular liver necrosis.
1(0,0,0,1) Details
19141029 Yan Y, Xu W, Qian H, Si Y, Zhu W, Cao H, Zhou H, Mao F: Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int. 2009 Mar;29(3):356-65. Epub 2008 Dec 29.


METHODS: Human umbilical cord-derived mesenchymal stem cells, characterized by flow cytometry, were transplanted into carbon tetrachloride (CCl (4))-injured mice, and then followed for determination of localization and differentiation.
0(0,0,0,0) Details