| Name | PDGFR |
|---|---|
| Synonyms | Beta platelet derived growth factor receptor; Beta platelet derived growth factor receptor precursor; CD140B; CD140b antigen; JTK12; PDGF receptor beta; PDGF R beta; PDGFR… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18762776 | Krampert M, Heldin CH, Heuchel RL: A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin. Lab Invest. 2008 Nov;88(11):1204-14. Epub 2008 Sep 1. We observed a higher basal activation of mutant PDGFR-beta in unchallenged livers; however, the difference in activation upon carbon tetrachloride stimulation was lower than expected, an effect that might be explained by a delayed response of the mutated receptor toward reactive species. |
36(0,1,1,6) | Details |
| 18663351 | Borkham-Kamphorst E, Kovalenko E, van Roeyen CR, Gassler N, Bomble M, Ostendorf T, Floege J, Gressner AM, Weiskirchen R: Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury. Lab Invest. 2008 Oct;88(10):1090-100. Epub 2008 Jul 28. Induction of PDGF receptor type-beta (PDGFR beta) in HSC is well documented in single-dose carbon tetrachloride (CCl (4))-induced acute liver injury. |
33(0,1,1,3) | Details |
| 15623374 | Lu CH, Chen YX, Zhang ZB, Xie WF, Huang JF, Ni RZ, Guo YJ, Wei LX, Jin YX: [The expression of platelet-derived growth factor (PDGF) receptor-beta and its correlation with extracellular matrix in hepatic tissue in hepatic fibrosis rats.]. Zhonghua Gan Zang Bing Za Zhi. 2004 Nov;12(11):663-5. METHODS: The model of hepatic fibrosis in rats was induced by carbon tetrachloride. |
8(0,0,0,8) | Details |
| 18509379 | Chen SW, Chen YX, Zhang XR, Qian H, Chen WZ, Xie WF: Targeted inhibition of platelet-derived growth factor receptor-beta subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats. Gene Ther. 2008 Nov;15(21):1424-35. Epub 2008 May 29. Platelet-derived growth factor (PDGF) is the most potent mitogen for HSCs, and PDGF receptor-beta subunit (PDGFR-beta) is required for the proliferation of HSCs induced by PDGF. The double-staining immunofluorescence examination indicated that GFAP promoter could target the transgene expression into HSCs in carbon tetrachloride induced acute injured rat's liver and bile duct ligation (BDL)-induced chronic injured rat's liver. |
4(0,0,0,4) | Details |
| 17133483 | Jeong WI, Park O, Radaeva S, Gao B: STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology. 2006 Dec;44(6):1441-51. Our findings show that disruption of the STAT1 gene accelerated liver fibrosis and hepatic stellate cell (HSC) proliferation in an in vivo model of carbon tetrachloride (CCl4)-induced liver fibrosis. Moreover, compared to wild-type cells, cellular proliferation stimulated by serum or platelet-derived growth factor (PDGF) was enhanced and accelerated in STAT1-/- HSCs, which was partially mediated via elevated PDGF receptor beta expression on such cells. |
1(0,0,0,1) | Details |
| 17069927 | Guyot C, Combe C, Balabaud C, Bioulac-Sage P, Desmouliere A: Fibrogenic cell fate during fibrotic tissue remodelling observed in rat and human cultured liver slices. J Hepatol. 2007 Jan;46(1):142-50. Epub 2006 Oct 4. METHODS: Fibrosis was induced in rats by carbon tetrachloride (CCl4) treatment or bile duct ligation. PCLS were cultured for 6, 24, 48, or 72 h, and the expression of alpha-smooth muscle (SM) actin, platelet-derived growth factor (PDGF) receptor-beta, and active caspase 3 was studied by immunohistochemistry. |
3(0,0,0,3) | Details |
| 19646978 | Yasuda Y, Shimizu M, Sakai H, Iwasa J, Kubota M, Adachi S, Osawa Y, Tsurumi H, Hara Y, Moriwaki H: (-)- prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R. Chem Biol Interact. 2009 Dec 10;182(2-3):159-64. Epub 2009 Jul 30. Activated hepatic stellate cells (HSCs) play a critical role in the development of liver fibrosis and the axis of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR), a member of receptor tyrosine kinases (RTKs), is closely associated with the activation of HSC. |
2(0,0,0,2) | Details |
| 20056141 | Lou JL, Jiang MN, Li C, Zhou Q, He X, Lei HY, Li J, Jia YJ: Herb medicine Gan-fu-kang attenuates liver injury in a rat fibrotic model. J Ethnopharmacol. 2010 Mar 2;128(1):131-8. Epub 2010 Jan 6. MATERIALS AND METHODS: Liver fibrosis was established by 12 weeks of carbon tetrachloride (CCl (4)) treatment (0.5mg/kg, twice per week) followed by 8 weeks of "recovery" in rats. RESULTS AND CONCLUSIONS: (1) CCl (4) treatment resulted in severe liver damage and fibrosis. (2) In the main block of the 20-week study, GFK attenuated liver damage and fibrosis. (3) In the 12-week study, GFK produced prevention effect against hepatic injury. (4) GFK suppressed the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), type I collagen, platelet-derived growth factor-BB (PDGF-BB)/PDGF receptor-beta chains (PDGFRbeta) and mitogen-activated protein kinases (MAPKs)/active protein-1 (AP-1) signal pathways. |
1(0,0,0,1) | Details |
| 16596278 | Yoshiji H, Kuriyama S, Noguchi R, Ikenaka Y, Yoshii J, Yanase K, Namisaki T, Kitade M, Yamazaki M, Asada K, Akahane T, Tsujimoto T, Uemura M, Fukui H: Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-beta with a combination of imatinib mesylate and ACE inhibitor in rats. Int J Mol Med. 2006 May;17(5):899-904. Our in vitro study demonstrated that STI-571 and ACE-I suppressed PDGF receptor (PDGFR) phosphorylation and TGF-beta expression in activated HSCs, respectively. |
1(0,0,0,1) | Details |