Protein Information

Name CD14
Synonyms CD14; PTX 1; PTX1; CDA14; Cd002; ERGIC and golgi 2; ERGIC 2; ERGIC2…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
16045604 Qiu DK, Hua J, Li JQ, Li EL: CD14 expression on Kupffer cells during the course of carbon tetrachloride-mediated liver injury. Chin J Dig Dis. 2005;6(3):137-41.
65(0,2,2,5) Details
16964416 Qian H, Wang J, Wang S, Gong Z, Chen M, Ren Z, Huang S: In utero transplantation of human hematopoietic stem/progenitor cells partially repairs injured liver in mice. Int J Mol Med. 2006 Oct;18(4):633-42.

The aim of this study is to establish a novel mouse model with high achievement and chimerism by in utero transplantation of human hematopoietic stem/progenitor cells and to explore the possibility that human adult hematopoietic stem/progenitor cells can differentiate into hepatocyte-like cells and partially repair the liver damage induced by carbon tetrachloride (CCl (4)).
At one month after birth, the specific markers of human cells, human alpha-satellite sequence (h17alpha), CD14, CD34, CD45, and GPA were detected by PCR and FACS.
1(0,0,0,1) Details
18824281 Fang HL, Lai JT, Lin WC: Inhibitory effect of olive oil on fibrosis induced by carbon tetrachloride in rat liver. Clin Nutr. 2008 Dec;27(6):900-7. Epub 2008 Sep 27.

RESULTS: RT-PCR analysis showed that CCl (4) increased the hepatic mRNA expressions of lipopolysaccharide binding protein, CD14, Toll-like receptor-4, NADPH oxidase, nuclear factor-kappa beta, collagen (alpha1) (I), collagen (alpha1) (III), and transforming growth factor beta1.
1(0,0,0,1) Details
19443073 Lafdil F, Chobert MN, Deveaux V, Zafrani ES, Mavier P, Nakano T, Laperche Y, Brouillet A: Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice. J Hepatol. 2009 Jul;51(1):55-66. Epub 2009 Apr 22.

METHODS: Toxic hepatitis was induced by a single carbon tetrachloride injection in Gas6 deficient (Gas6 (-/-)) mice and liver recovery was compared with wild-type animals.
At 72 h, an efficient tissue repair was observed in wild-type animals whereas in Gas6 (-/-) mice, we noticed a defective wound healing accounted by reduced Kupffer cell activation revealed by a decrease in the induction of CD14, TNF-alpha, IL6 and MCP-1.
1(0,0,0,1) Details