Protein Information

Name HSP72
Synonyms HSP70 1; HSP72; HSPA 1; HSPA1; HSPA1A; HSPA1B; Heat shock 70 KD protein 1A; Heat shock 70KD protein 1…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
15242491 Mikami K, Otaka M, Goto T, Miura K, Ohshima S, Yoneyama K, Lin JG, Watanabe D, Segawa D, Kataoka E, Odashima M, Watanabe S: Induction of a 72-kDa heat shock protein and protection against lipopolysaccharide-induced liver injury in cirrhotic rats. J Gastroenterol Hepatol. 2004 Aug;19(8):884-90.

In this study, we investigated the cytoprotective effect of HSP72 on lipopolysaccharide (LPS)-induced liver injury in carbon tetrachloride (CCl (4))-induced cirrhotic rats.
11(0,0,1,6) Details
15338365 Watanabe D, Otaka M, Mikami K, Yoneyama K, Goto T, Miura K, Ohshima S, Lin JG, Shibuya T, Segawa D, Kataoka E, Konishi N, Odashima M, Sugawara M, Watanabe S: Expression of a 72-kDa heat shock protein, and its cytoprotective function, in gastric mucosa in cirrhotic rats. J Gastroenterol. 2004 Aug;39(8):724-33.

Many studies, including ours, have reported that a 72-kDa heat shock protein (HSP72) has a crucial cytoprotective function in gastric mucosa.
METHODS: PHG was produced by bile duct ligation (BDL) or carbon tetrachloride administration in male Sprague-Dawley rats.
8(0,0,0,8) Details
18547752 Yamaji K, Ochiai Y, Ohnishi K, Yawata A, Chikuma T, Hojo H: Up-regulation of hepatic heme oxygenase-1 expression by locally induced interleukin-6 in rats administered carbon tetrachloride intraperitoneally. Toxicol Lett. 2008 Jul 10;179(3):124-9. Epub 2008 May 2.

The expression of heme oxygenase-1 (HO-1) (EC 1.14.99.3) mRNA and protein were induced more in rats administered CCl4 via the i.p. route, compared with the p.o. route; however, expression of heat shock protein (HSP) 72 and HSP90 mRNA were increased to similar extents in both experimental groups.
1(0,0,0,1) Details