| Name | glutathione reductase |
|---|---|
| Synonyms | GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15991578 | Pradeep K, Mohan CV, Anand KG, Karthikeyan S: Effect of pretreatment of Cassia fistula Linn. leaf extract against subacute CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2005 Jun;43(6):526-30. CCl4 alone treatment (0.lml of liquid paraffin/100g body weight, ip) for 7 days followed by 0.l ml of CCl4 (in liquid parafiin/100g body weight, ip) from day 8 till day 14, caused a 16 fold increase in lipid peroxidation and a 50% reduction in catalase and glutathione reductase in liver tissue of rats accompanied by an increase in the activities of transaminases. alkaline phosphatase, lactate dehydrogenase and gamma - glutamyl transpeptidase in serum as compared to liquid paraffin treated control. |
2(0,0,0,2) | Details |
| 15900908 | Sultana S, Ahmad S, Khan N, Jahangir T: Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats. Indian J Exp Biol. 2005 May;43(5):430-6. A single dose of CCl4 (1 ml/kg body weight, po in corn oil) increased the levels of SGOT (serum transaminase), SGPT (serum glutamate pyruvate transaminase), LDH (lactate dehydrogenase), glutathione-S-transferase and depletion in peroxidase and glutathione reductase. |
2(0,0,0,2) | Details |
| 19596425 | Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY: Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. Fitoterapia. 2010 Jan;81(1):1-7. Epub 2009 Jul 8. A herbal preparation "Compound Codyceps-TCM-700C (CC-700C)" was tested for hepatoprotective effect against the carbon tetrachloride induced liver damages in Sprague-Dawley rat model for a period of 6-weeks. Moreover, although levels of (GSH), glutathione reductase (GSH-Rd), and superoxide dismutase (SOD) were equally maintained by these three preparations, peroxidase (GSH-Px) was suppressed only by H-TCM, and SOD only by Silymarin. |
1(0,0,0,1) | Details |
| 19352025 | Quan J, Piao L, Xu H, Li T, Yin X: Protective effect of iridoid glucosides from Boschniakia rossica on acute liver injury induced by carbon tetrachloride in rats. Biosci Biotechnol Biochem. 2009 Apr 23;73(4):849-54. Epub 2009 Apr 7. The liver antioxidative defense system, including superoxide dismutase (SOD), peroxidase (GPx) and glutathione reductase (GR), as well as the cytochrome P450 2E1 (CYP2E1) expression were suppressed, however. |
1(0,0,0,1) | Details |
| 14757975 | Tang MH, Chiu PY, Ko KM: Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial status and induction of heat shock proteins in mice. Biofactors. 2003;19(1-2):33-42. The stimulatory effect of Sch B then gradually subsided, but the activities of hepatic mitochondrial glutathione reductase (GR) and glutathione S-transferases (GST) as well as the level of HSP 25 remained relatively high even at 72 h post-dosing. |
1(0,0,0,1) | Details |
| 19524009 | Hsu YW, Tsai CF, Chen WK, Lu FJ: Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2009 Sep;47(9):2281-8. Epub 2009 Jun 11. Moreover, the treatment of SBT seed oil was also found to significantly increase the activities of superoxide dismutase (SOD), catalase, peroxidase (GSH-Px), glutathione reductase (GSH-Rd), and GSH content in liver up to 134%. |
1(0,0,0,1) | Details |
| 19634318 | Lee MK, Kim SH, Yang H, Lim DY, Ryu JH, Lee ES, Jew SS, Park HG, Sung SH, Kim YC: Asiatic acid derivatives protect primary cultures of rat hepatocytes against carbon tetrachloride-induced injury via the cellular antioxidant system. Nat Prod Commun. 2009 Jun;4(6):765-8. Our findings showed that AS-10 and AS-14 preserved the level of and the activities of antioxidant enzymes such as glutathione reductase, peroxidase, superoxide dismutase and catalase. |
1(0,0,0,1) | Details |
| 17188414 | Lee CP, Shih PH, Hsu CL, Yen GC: Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem Toxicol. 2007 Jun;45(6):888-95. Epub 2006 Nov 21. Pre-treatment of animals with tea seed oil (150 g/kg diet) could increase the activities of peroxidase, glutathione reductase and glutathione S transferase in liver when compared with CCl (4)-treated group (p <0.05). |
1(0,0,0,1) | Details |
| 16117609 | Kim NY, Lee MK, Park MJ, Kim SJ, Park HJ, Choi JW, Kim SH, Cho SY, Lee JS: Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83. The CCl4-treated rats had significantly lower activities of glutathione reductase, glutathione S-transferase, superoxide dismutase, catalase, and peroxidase. |
1(0,0,0,1) | Details |
| 19292473 | Kujawska M, Ignatowicz E, Murias M, Ewertowska M, Mikolajczyk K, Jodynis-Liebert J: Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. J Agric Food Chem. 2009 Mar 25;57(6):2570-5. Pretreatment with juice caused a partial recovery in the activity of peroxidase and glutathione reductase, by 35% and 66%, respectively. |
1(0,0,0,1) | Details |
| 19938218 | Chao J, Lee MS, Amagaya S, Liao JW, Wu JB, Ho LK, Peng WH: Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride. Am J Chin Med. 2009;37(6):1085-97. Moreover, the SDGL (EtOH) (100 and 500 mg/kg) increased the activities of anti-oxidative enzymes, superoxide dismutase (SOD), peroxidase (GPx) and glutathione reductase (GRd) and decreased malondialdehyde (MDA) level in liver, as compared to those in the CCl (4)-treated group. |
1(0,0,0,1) | Details |
| 19742242 | Shaarawy SM, Tohamy AA, Elgendy SM, Elmageed ZY, Bahnasy A, Mohamed MS, Kandil E, Matrougui K: Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity. Int J Biol Sci. 2009 Aug 11;5(6):549-57. BACKGROUND: The present study was conducted to investigate the chemopreventive effects of garlic extract and silymarin on N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl (4))-induced hepatotoxicity in male albino rats. Serum transaminase (AST), transaminase (ALT), alkaline phosphatase (ALP), hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), (GSH), glutathione-S-transferase (GST) and glutathione reductase (GSR) were measured. |
1(0,0,0,1) | Details |
| 18476390 | Anilakumar KR, Krishna KR, Chandramohan G, Khanum F, Bawa AS: Bees wax polyphenols as suppressor of CC1--induced oxidative stress in rats. Indian J Physiol Pharmacol. 2007 Oct-Dec;51(4):361-7. As the polyphenols are thought to protect cell constituents against oxidative damage through scavenging of free radicals, the present work was undertaken to evaluate the effects of polyphenols extracted from bees wax on the oxidative stress induced by carbon tetrachloride (CCl4) in rats. The results showed a significant decrease in hepatic antioxidant enzyme activities viz. catalase, glucose-6-phosphate dehydrogenase (G-6-PDH), peroxidase (GSH-Px), glutathione reductase, superoxide dismutase (SOD) and a significant increase in glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (GGT) by CCl4, probably due to the peroxidative effects. |
1(0,0,0,1) | Details |
| 16213120 | Rao GM, Rao CV, Pushpangadan P, Shirwaikar A: Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006 Feb 20;103(3):484-90. Epub 2005 Oct 5. The hepatoprotective effects of rubiadin, a major constituent isolated from Rubia cordifolia Linn., were evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Meanwhile, the decreased activities of glutathione S-transferase and glutathione reductase were also restored towards normalization. |
1(0,0,0,1) | Details |
| 18830880 | Khan TH, Sultana S: Antioxidant and hepatoprotective potential of Aegle marmelos Correa. against CCl4-induced oxidative stress and early tumor events. J Enzyme Inhib Med Chem. 2009 Apr;24(2):320-7. Hepatic antioxidant status viz, (GSH), glutathione reductase (GR), peroxidase (GPx), quinone reductase (QR), catalase (CAT) were concomitantly restored in A. marmelos-treated groups (p < 0.001). In conclusion, carbon tetrachloride-induced liver toxicity was strikingly attenuated by A. marmelos treatment and the study gives some insight into the mechanisms involved in diminution of free radical generating toxicants and enhancement of the antioxidant armory, hence preventing further tissue damage, injury and hyperproliferation. |
1(0,0,0,1) | Details |
| 17355462 | Naik SR, Panda VS: Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents. Liver Int. 2007 Apr;27(3):393-9. Further, the effects of GBP on lipid peroxidation (LPO), (GSH), superoxide dismutase (SOD), catalase (CAT), peroxidase (GPX) and glutathione reductase (GR) were estimated in liver homogenates to evaluate antioxidant activity. |
1(0,0,0,1) | Details |
| 19323752 | Kim DH, Song SB, Kang WS, Jeong YH, Yoon YS, Lee YM, Chang BS, Lee KJ: Superfine saengshik improves liver protecting effect compared with fine saengshik in an animal model. J Food Sci. 2009 Mar;74(2):H59-64. Also, the peroxidase (P < 0.01) and glutathione reductase (P < 0.05) activities in liver showed a significant difference between FS + CCl (4) and SS + CCl (4) groups. |
1(0,0,0,1) | Details |
| 17639719 | Makeeva AV, Popova TN, Matasova LV: action on -dependent antioxidant system functioning at toxic hepatitis of rats]. Biomed Khim. 2007 Mar-Apr;53(2):181-9. Injections of to animals with toxic hepatitis caused the decrease of glutathione reductase and peroxidase activities to the normal level. |
1(0,0,0,1) | Details |
| 15330565 | el-Sawy SA, el-Shafey AM, el-Bahrawy HA: Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver. East Mediterr Health J. 2002 Jan;8(1):95-104. DDB produced a significant increase in peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. |
1(0,0,0,1) | Details |
| 18761048 | Hsu YW, Tsai CF, Chang WH, Ho YC, Chen WK, Lu FJ: Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2008 Oct;46(10):3311-7. Epub 2008 Aug 12. Treatment with D. salina or silymarin could significantly (p <0.05) decrease the ALT, AST, and ALP levels in serum and increase the activities of SOD, catalase, GSH-Px, glutathione reductase, and GSH content and decrease the MDA content in liver when compared with CCl (4)-treated group. |
1(0,0,0,1) | Details |
| 16810758 | Shi ZM, Feng P, Jiang DQ, Wang XJ: Mistletoe alkali inhibits peroxidation in rat liver and kidney. . World J Gastroenterol. 2006 Jul 7;12(25):4052-5. METHODS: The antioxidant effect of mistletoe alkali on the oxidative stress induced by carbon tetrachloride (CCl4) in rats was investigated. Also, the level of (GSH), and activities of glutathione reductase (GR), peroxidase (GSPx), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in liver and kidney were determined. |
1(0,0,0,1) | Details |