| Name | ATase |
|---|---|
| Synonyms | ATASE; ATase; Amidophosphoribosyltransferase; Amidophosphoribosyltransferase precursor; GPAT; Glutamine phosphoribosylpyrophosphate amidotransferase; PPAT; Phosphoribosyl pyrophosphate amidotransferase proprotein variant… |
| Name | ethylene dibromide |
|---|---|
| CAS | 1,2-dibromoethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9363995 | Abril N, Luque-Romero FL, Prieto-Alamo MJ, Rafferty JA, Margison GP, Pueyo C: Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes. Carcinogenesis. 1997 Oct;18(10):1883-8. Here we confirm and extend our previous studies demonstrating that the mutagenic potency of 1,2-dibromoethane (DBE) and dibromomethane (DBM) is markedly enhanced (not prevented) in bacteria expressing the O6-alkylguanine-DNA alkyltransferase (ATase) encoded by the Escherichia coli ogt gene. |
6(0,0,0,6) | Details |
| 10368318 | Abril N, Margison GP: Mammalian cells expressing Escherichia coli O6-alkylguanine-DNA alkyltransferases are hypersensitive to dibromoalkanes. Chem Res Toxicol. 1999 Jun;12(6):544-51. The effect of expression of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, on the growth inhibitory effects of the dibromoalkanes (DBA) dibromomethane (DBM) and dibromoethane (DBE) was determined in Chinese hamster lung fibroblasts transfected with and expressing high levels of the Escherichia coli alkyltransferase (ATase) genes. |
5(0,0,0,5) | Details |
| 7662116 | Abril N, Luque-Romero FL, Prieto-Alamo MJ, Margison GP, Pueyo C: ogt alkyltransferase enhances dibromoalkane mutagenicity in excision repair-deficient Escherichia coli Mol Carcinog. 1995 Feb;12(2):110-7. Induced mutations occurred only in excision repair-defective strains and were totally (with dibromomethane) or substantially (with dibromoethane) dependent on the alkyltransferase (ATase) encoded by the ogt gene. |
4(0,0,0,4) | Details |