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Manjeshwar S, Sheikh A, Pichiri-Coni G, Coni P, Rao PM, Rajalakshmi S, Pediaditakis P, Michalopoulos G, Sarma DS: Orotic acid, nucleotide-pool imbalance, and liver-tumor promotion: a possible mechanism for the mitoinhibitory effects of orotic acid in isolated rat hepatocytes. Cancer Res. 1992 Apr 1;52(7 Suppl):2078s-2081s.
Orotic acid inhibited, dose-dependently DNA synthesis in hepatocytes induced by epidermal growth factor, transforming growth factor alpha, hepatocyte growth factor, acidic fibroblast growth factor, or plasma from rats exposed to various liver cell-proliferative stimuli, such as two-thirds partial hepatectomy, lead nitrate, cyproterone acetate, ethylene dibromide, or a diet deficient in choline. |
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