| 16232514 |
Park HJ, Choi WJ, Huh EC, Lee EY, Choi CY: Production of optically active ketoprofen by direct enzymatic esterification. J Biosci Bioeng. 1999;87(4):545-7.
Ethanol was used as the alkyl donor and the optimum water content required for highly efficient enzymatic resolution was determined to be 0.1-0.15% (v/v), which was maintained using salt hydrates such as Na2SO4 x 10H2O. (S)-Ketoprofen could be obtained with high enantioselectivity (E=15) in n-hexane supplemented with ethylene dichloride (20% (v/v)) using commercially available Candida antarctica lipase (Novozym 435). |
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