| Name | transferase |
|---|---|
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| Name | methylene chloride |
|---|---|
| CAS | dichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15369734 | Cha YY, Lee EO, Lee HJ, Park YD, Ko SG, Kim DH, Kim HM, Kang IC, Kim SH: Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway. Clin Chim Acta. 2004 Oct;348(1-2):41-8. METHODS: With methylene chloride fraction of Herba Scutellariae barbatae (MCSB), apoptosis-related experiments were carried out on human U937 leukemia cells by (a) 2,3-bis [2-4-nitro-5-sulphophenyl] 2H-tetrazolium-5-carboxanilide (XTT) assay for cytotoxicity; (b) terminal deoxynucleotidyl-transferase-mediated nick end labeling (TUNEL) assay for morphological changes; (c) cell cycle analysis; (d) Western blot analysis of poly (ADP- polymerase (PARP), caspase-8, caspase-9, caspase-3 and Bax, Bcl-2 and cytochrome c expressions for apoptosis signaling pathway. |
31(0,1,1,1) | Details |
| 9307035 | Sherratt PJ, Pulford DJ, Harrison DJ, Green T, Hayes JD: Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse. Biochem J. 1997 Sep 15;326 ( Pt 3):837-46. The cDNA encoding human glutathione S-transferase (GST) T1 has been expressed as two recombinant forms in Escherichia coli that could be purified by affinity chromatography on either IgG-Sepharose or -agarose; one form of the transferase was synthesized from the pALP 1 expression vector as a Staphylococcus aureus protein A fusion, whereas the other form was synthesized from the pET-20b expression vector as a C-terminal polyhistidine-tagged recombinant. |
2(0,0,0,2) | Details |
| 11884241 | Sherratt PJ, Williams S, Foster J, Kernohan N, Green T, Hayes JD: Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity. Toxicol Appl Pharmacol. 2002 Mar 1;179(2):89-97. The species specificity is thought to be due to the greater amount of transferase activity in mouse target organs and specific nuclear localization of GST T1-1 in target cells. |
2(0,0,0,2) | Details |
| 12751236 | Trotsenko IuA, Doronina NV: [The biology of aerobic methylobacteria capable of degrading halomethanes] . Mikrobiologiia. 2003 Mar-Apr;72(2):149-60. The initial steps of chloromethane dehalogenation to and HCl through a methylated and methyletrahydrofolate are catalyzed by inducible methyl transferase, made up of two proteins (CmuA and CmuB) encoded by the cmuA and cmuB genes. |
1(0,0,0,1) | Details |
| 8100433 | Pankow D, Jagielki S: Effect of or modifications of the hepatic concentration on the metabolism of dichloromethane to in rats. Hum Exp Toxicol. 1993 May;12(3):227-31. The two pathways of DCM, the oxidative via CYP 2E1 and the metabolism via GSH/GSH-S-transferase seem to be independent. |
1(0,0,0,1) | Details |
| 14727918 | Marsch GA, Botta S, Martin MV, McCormick WA, Guengerich FP: Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl) and by glutathione S-transferase-mediated activation of dihalomethanes. Chem Res Toxicol. 2004 Jan;17(1):45-54. The relative efficiency of adduct formation by GSH transferases was rat 5-5 > human T1-1 > bacterial DM11, showing that human GSH transferase T1-1 can form dihalomethane adducts under the conditions used. |
1(0,0,0,1) | Details |
| 8761485 | Mainwaring GW, Williams SM, Foster JR, Tugwood J, Green T: The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. Biochem J. 1996 Aug 15;318 ( Pt 1):297-303. Low levels of human transferase GSTT1-1 were detected in a small number of Clara cells and ciliated cells at the alveolar/ bronchiolar junction. The relative activities between species, and the cellular and sub-cellular distribution within the liver and lungs of each species, provides an explanation for the species-specificity of methylene chloride, a mouse-specific carcinogen activated by glutathione S-transferase GSTT1-1. |
1(0,0,0,1) | Details |