| Name | protein C |
|---|---|
| Synonyms | A1 activator; PSAP; Protein C; CSAct; Cerebroside sulfatase activator; Cerebroside sulfate activator; Co beta glucosidase; Component C… |
| Name | methylene chloride |
|---|---|
| CAS | dichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10425324 | Zambaux MF, Bonneaux F, Gref R, Dellacherie E, Vigneron C: Preparation and characterization of protein C-loaded PLA nanoparticles. J Control Release. 1999 Aug 5;60(2-3):179-88. It appears that a short time of sonication as well as the addition of to methylene chloride (1/1) limited the lost of protein C activity. |
13(0,0,1,8) | Details |
| 19788064 | Rajkumar R, Ilayaraja R, Mucignat C, Cavaggioni A, Archunan G: Identification of alpha2u-globulin and bound volatiles in the Indian common house rat (Rattus rattus). Indian J Biochem Biophys. 2009 Aug;46(4):319-24. The results of MASCOT search identified the protein as an alpha2u and suggested a role for binding pheromones. |
1(0,0,0,1) | Details |
| 11453994 | Gisi D, Maillard J, Flanagan JU, Rossjohn J, Chelvanayagam G, Board PG, Parker MW, Leisinger T, Vuilleumier S: Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants. Eur J Biochem. 2001 Jul;268(14):4001-10. A structural model of rat GST T1-1 suggested that sequence variation was clustered around the activation site and at the protein C-terminus believed to cap the active site. |
1(0,0,0,1) | Details |
| 19781605 | Bordes C, Freville V, Ruffin E, Marote P, Gauvrit JY, Briancon S, Lanteri P: Determination of poly (epsilon-caprolactone) solubility parameters: application to solvent substitution in a microencapsulation process. Int J Pharm. 2010 Jan 4;383(1-2):236-43. Epub 2009 Sep 23. In this context, the method of Hansen solubility parameters was applied to identify an alternative solvent less toxic than methylene chloride used in a microencapsulation process. During the process based on a multiple emulsion (W/O/W) with solvent evaporation/extraction method, the solvent has to dissolve a polymer, poly (epsilon-caprolactone) (PCL), which forms a polymeric matrix encapsulating or entrapping a therapeutic protein as the solvent is extracted. |
1(0,0,0,1) | Details |
| 9307035 | Sherratt PJ, Pulford DJ, Harrison DJ, Green T, Hayes JD: Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse. Biochem J. 1997 Sep 15;326 ( Pt 3):837-46. The cDNA encoding human glutathione S-transferase (GST) T1 has been expressed as two recombinant forms in Escherichia coli that could be purified by affinity chromatography on either IgG-Sepharose or -agarose; one form of the transferase was synthesized from the pALP 1 expression vector as a Staphylococcus aureus protein A fusion, whereas the other form was synthesized from the pET-20b expression vector as a C-terminal polyhistidine-tagged recombinant. |
3(0,0,0,3) | Details |
| 10691188 | Chognot D, Zambaux MF, Bonneaux F, Gaussem P, Pittet JL, Aiach M, Vigneron C: Identification of protein C epitopes altered during its nanoencapsulation. J Protein Chem. 1999 Oct;18(7):779-84. The correlation between the immunological assay and a functional one i.e. by the means of the assay of its anticoagulant activity (activated partial thromboplastin time) made it possible to show that protein C amino acids 166-169 of the activation peptide were probably altered after ultrasonication and methylene chloride treatment. |
34(0,1,1,4) | Details |