Protein Information

Name HPRT
Synonyms HGPRT; hPrt1; HGPRTase; HPRT; HPRT 1; HPRT1 protein; Hypoxanthine phosphoribosyltransferase 1; Hypoxanthine guanine phosphoribosyltransferase…

Compound Information

Name methylene chloride
CAS dichloromethane

Reference List

PubMed Abstract RScore(About this table)
8600370 Graves RJ, Green T: Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay. Mutat Res. 1996 Mar 1;367(3):143-50.
33(0,1,1,3) Details
7523909 Tates AD, Grummt T, van Dam FJ, de Zwart F, Kasper FJ, Rothe R, Stirn H, Zwinderman AH, Natarajan AT: Measurement of frequencies of HPRT mutants, chromosomal aberrations, micronuclei, sister-chromatid exchanges and cells with high frequencies of SCEs in styrene/dichloromethane-exposed workers. Mutat Res. 1994 Oct-Dec;313(2-3):249-62.

Frequencies of HPRT mutants (MFs), chromosomal aberrations with or without gaps (CA+; CA-), aberrant cells (AC), micronuclei (MN), sister-chromatid exchanges (SCEs) and cells with high frequencies of SCEs (HFCs) were measured in lymphocytes collected from 46 workers occupationally exposed to styrene and dichloromethane (DCM = methylene chloride).
8(0,0,1,3) Details
8671744 Graves RJ, Trueman P, Jones S, Green T: DNA sequence analysis of methylene chloride-induced HPRT mutations in Chinese hamster ovary cells: comparison with the mutation spectrum obtained for 1,2-dibromoethane and formaldehyde. Mutagenesis. 1996 May;11(3):229-33.
7(0,0,1,2) Details