Protein Information

Name fibronectin
Synonyms CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1…

Compound Information

Name boric acid
CAS

Reference List

PubMed Abstract RScore(About this table)
12481254 Gallardo-Williams MT, Maronpot RR, Wine RN, Brunssen SH, Chapin RE: Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid. Prostate. 2003 Jan 1;54(1):44-9.

Fibronectin, a biologically relevant substrate for PSA, was used as a substrate in a zymographic assay, and the degradation of fibronectin by PSA in the presence of boric acid and NPBA was followed by Western Blot.
114(1,2,2,4) Details
14713551 Gallardo-Williams MT, Chapin RE, King PE, Moser GJ, Goldsworthy TL, Morrison JP, Maronpot RR: Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice. Toxicol Pathol. 2004 Jan-Feb;32(1):73-8.

Also, by Western blot we have followed the degradation of fibronectin by enzymatically active PSA and have found significant inhibition in the presence of boric acid.
81(1,1,1,1) Details
19262119 Bradke TM, Hall C, Carper SW, Plopper GE: Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability. Cell Adh Migr. 2008 Jul;2(3):153-60. Epub 2008 Jul 23.


We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues.
0(0,0,0,0) Details