Protein Information

Name xanthine oxidase
Synonyms XDH; XDHA; XO; XOD; XOR; Xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase…

Compound Information

Name boric acid
CAS

Reference List

PubMed Abstract RScore(About this table)
4003757 Smithers GW, O'Sullivan WJ: Hypoxanthine phosphoribosyltransferase: radiochemical assay procedures for the forward and reverse reactions. Anal Biochem. 1985 Feb 15;145(1):14-20.

Enzyme activity in the reverse direction was assessed by measuring the amount of [8-14C] uric acid formed from the labeled IMP following their separation by polyethyleneimine-cellulose TLC in 0.2 M LiCl saturated with boric acid (pH 4.5):95% ethanol (1:1, v/v), the transferase reaction being coupled with excess xanthine oxidase and catalase to overcome the unfavorable equilibrium.
81(1,1,1,1) Details
16669089 Lukaszewski KM, Blevins DG, Randall DD: Asparagine and Boric Acid Cause Allantoate Accumulation in Soybean Leaves by Inhibiting Manganese-Dependent Allantoate Amidohydrolase. Plant Physiol. 1992 Aug;99(4):1670-1676.

Accumulation of allantoate was also observed when asparagine was supplied in the presence of allopurinol, an inhibitor of xanthine dehydrogenase in the pathway of ureide biosynthesis.
1(0,0,0,1) Details
8804918 Chen JC, Fine RE, Squicciarini J, Volicer L: Neurotoxicity of free-radical-mediated serotonin neurotoxin in cultured embryonic chick brain neurons. Eur J Pharmacol. 1996 May 6;303(1-2):109-14.

Exposure of serotonin (5-HT) to oxygen-derived free-radical-generating system, xanthine oxidase-hypoxanthine or to a Fenton reaction results in the formation of the neurotoxin, tryptamine-4,5-dione.
However, the toxicity caused by tryptamine-4,5-dione and glutathione conjugate could not be blocked by fluoxetine (10 or 100 microM) or by a glutathione transferase inhibitor, boric acid/serine.
1(0,0,0,1) Details
14800400 ROUSH A, NORRIS ER: The inhibition of xanthine oxidase by borates. Arch Biochem. 1950 Dec;29(2):344-7.

1(0,0,0,1) Details