Protein Information

Name transferrin
Synonyms Beta 1 metal binding globulin; PRO1400; PRO1557; PRO2086; Serotransferrin; Serotransferrin precursor; Siderophilin; TF…

Compound Information

Name boric acid
CAS

Reference List

PubMed Abstract RScore(About this table)
12793906 Dominici S, Pieri L, Comporti M, Pompella A: Possible role of membrane gamma-glutamyltransferase activity in the facilitation of transferrin-dependent and -independent iron uptake by cancer cells. Cancer Cell Int. 2003 May 14;3(1):7.

Accordingly, inhibition of GGT activity by means of two independent inhibitors, acivicin and serine/boric acid complex, resulted in a decreased uptake of transferrin-bound iron.
85(1,1,1,5) Details
9870409 Tagliaro F, Crivellente F, Manetto G, Puppi I, Deyl Z, Marigo M: Optimized determination of carbohydrate-deficient transferrin isoforms in serum by capillary zone electrophoresis. Electrophoresis. 1998 Nov;19(16-17):3033-9.

Separation was performed with a capillary zone electrophoretic method using bare fused-silica capillaries (20 microm ID, 37 cm in length) and a buffer composed of 100 mM sodium tetraborate adjusted with boric acid to pH 8.3.
8(0,0,0,8) Details
7588530 Hjerten S, Valtcheva L, Elenbring K, Liao JL: Fast, high-resolution (capillary) electrophoresis in buffers designed for high field strengths. Electrophoresis. 1995 Apr;16(4):584-94.

For instance, albumin and transferrin were separated at 30,000 V (1.99 microA) in 15 cm long fused silica capillaries (50 microns ID) within 40 s and the carboxylic acids within 25 s.
Although not verified experimentally we also suggest the use of relatively high-molecular-weight polyoxyethylene derivatized with one acidic group (for instance, boric acid) and one basic group (an amine), both having the same pK value, which should afford both a very high buffering capacity and very low electrical conductivity (at low buffer concentrations).
1(0,0,0,1) Details
8679151 Middelweerd MJ, de Vries N, Calliauw J, van Kamp GJ: A new biochemical assay in the diagnostic management of nasal cerebrospinal fluid leakage. Eur Arch Otorhinolaryngol. 1995;252(6):336-9.


Genetic variants of transferrin (which has a general population incidence of 2-4%) can be discriminated from false-positive test results in affected families.
1(0,0,0,1) Details